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Study · In vitro (cells) · opossum · 1995

2 results

The processing of insulin-like growth factor-I (IGF-I) by a cultured kidney cell line is altered by IGF-binding protein-3.

Fawcett J, Rabkin R

Endocrinology1 Apr 1995Cited by 4 (Europe PMC)

PMID7534695 (opens in a new tab)DOI10.1210/endo.136.4.7534695 (opens in a new tab)PepBankPUB-07534695
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In opossum kidney cells, Des(1‑3)-IGF-I inhibited labeled IGF-I cell association as effectively as IGF-I.

    In plain wordsIn cells, Des(1‑3)-IGF-I blocked labeled IGF-I association as effectively as IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeCompetitive inhibition of labeled IGF-I cell association
    Study

    opossumn: not reported in source

    Opossum kidney cell line
    Comparator
    IGF-I
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Des(1-3)-IGF-I was equally effective, insulin had only a small effect, and the unrelated peptides, glucagon and GH, were without effect.
    1 context sentence
    Summary · context
    [125I]IGF-I associated with these cells in a specific manner. Association was competitively inhibited by IGF-I.
  2. 02LabIn vitro (cells)Mechanism

    In opossum kidney cells, Des(1‑3)-IGF-I inhibited labeled IGF-I degradation similarly to IGF-I.

    In plain wordsIn cells, Des(1‑3)-IGF-I blocked labeled IGF-I breakdown similarly to IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeInhibition of labeled IGF-I degradation
    Study

    opossumn: not reported in source

    Opossum kidney cell line
    Comparator
    IGF-I
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Degradation was inhibited in similar manner.
    1 context sentence
    Summary · context
    Association was competitively inhibited by IGF-I. Des(1-3)-IGF-I was equally effective, insulin had only a small effect, and the unrelated peptides, glucagon and GH, were without effect.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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