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Study · In vitro (cells) · rat · 1995

4 results

Skeletal muscle cell-derived insulin-like growth factor (IGF) binding proteins inhibit IGF-I-induced myogenesis in rat L6E9 cells.

Silverman LA, Cheng ZQ, Hsiao D, Rosenthal SM

Endocrinology1 Feb 1995Cited by 32 (Europe PMC)

PMID7530651 (opens in a new tab)DOI10.1210/endo.136.2.7530651 (opens in a new tab)PepBankPUB-07530651
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In rat L6E9 cells, des(1‑3)IGF-I treatment further increased IGFBP-4 accumulation during differentiation.

    In plain wordsIn cells, des(1‑3)IGF-I further increased IGFBP-4 during differentiation.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGFBP-4 accumulation
    Study

    ratn: not reported in source

    L6E9 skeletal myoblasts
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both IGFBP-4 and BP-6 accumulate during differentiation and increase further in response to IGF-I or des(1-3)IGF-I treatment.
  2. 02LabIn vitro (cells)Mechanism

    In rat L6E9 cells, des(1‑3)IGF-I treatment further increased IGFBP-6 accumulation during differentiation.

    In plain wordsIn cells, des(1‑3)IGF-I further increased IGFBP-6 during differentiation.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGFBP-6 accumulation
    Study

    ratn: not reported in source

    L6E9 skeletal myoblasts
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both IGFBP-4 and BP-6 accumulate during differentiation and increase further in response to IGF-I or des(1-3)IGF-I treatment.
  3. 03LabIn vitro (cells)Mechanism

    In rat L6E9 cells, des(1‑3)IGF-I stimulated myogenesis assessed by myogenin messenger RNA more potently than native IGF-I.

    In plain wordsIn cells, des(1‑3)IGF-I stimulated muscle differentiation assessed by myogenin RNA more potently than native IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseMyogenin messenger RNA abundance
    Study

    ratn: not reported in source

    L6E9 skeletal myoblasts
    Comparator
    Native IGF-I
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We find that an IGF-I analog with reduced affinity for IGFBPs is significantly more potent than native IGF-I in stimulating myogenesis (as assessed by myogenin messenger RNA abundance and muscle creatine kinase activity), indicating that IGFBPs expressed by skeletal muscle cells inhibit differentiat…
    1 context sentence
    Summary · context
    To explore the role of skeletal muscle-derived IGFBPs in IGF-induced myogenesis, we compared the differentiation-inducing effects of IGF-I and des(1-3)IGF-I in rat L6E9 skeletal myoblasts.
  4. 04LabIn vitro (cells)Mechanism

    In rat L6E9 cells, des(1‑3)IGF-I stimulated myogenesis assessed by muscle creatine kinase activity more potently than native IGF-I.

    In plain wordsIn cells, des(1‑3)IGF-I stimulated muscle differentiation assessed by creatine kinase activity more potently than native IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseMuscle creatine kinase activity
    Study

    ratn: not reported in source

    L6E9 skeletal myoblasts
    Comparator
    Native IGF-I
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We find that an IGF-I analog with reduced affinity for IGFBPs is significantly more potent than native IGF-I in stimulating myogenesis (as assessed by myogenin messenger RNA abundance and muscle creatine kinase activity), indicating that IGFBPs expressed by skeletal muscle cells inhibit differentiat…
    1 context sentence
    Summary · context
    To explore the role of skeletal muscle-derived IGFBPs in IGF-induced myogenesis, we compared the differentiation-inducing effects of IGF-I and des(1-3)IGF-I in rat L6E9 skeletal myoblasts.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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