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Study · Measured the body's own peptide · 1994

3 results

Inhibitory control of nitric oxide on the arginine-vasopressin and oxytocin response to hypoglycaemia in normal men.

Chiodera P, Volpi R, Coiro V

Neuroreport1 Sept 1994Cited by 23 (Europe PMC)

PMID7530064 (opens in a new tab)DOI10.1097/00001756-199409080-00034 (opens in a new tab)PepBankPUB-07530064
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialOther

    In normal men, saline or the NO synthase inhibitor L-NAME alone did not change basal plasma OT levels.

    In plain wordsIn healthy men, a drug that blocks nitric oxide did not change the body's own oxytocin levels at rest.

    Peptide
    Oxytocin
    Outcome
    No significant changeBasal plasma OT after saline or L-NAME
    Study

    n = 6

    Comparator
    Saline
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    The administration of saline or L-NAME alone was unable to change basal AVP or OT levels.
    1 context sentence
    Summary · context
    six normal men were treated with placebo (normal saline) or the NO synthase inhibitor N,G-nitro-L-arginine methyl ester (L-NAME), given at doses (40 micrograms kg-1 injected plus 50 micrograms kg-1 infused i.v.) previously found to be unable to change blood pressure

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelNon-randomized trialOther

    In normal men, insulin-induced hypoglycaemia raised plasma OT two-fold in the absence of L-NAME.

    In plain wordsIn healthy men, low blood sugar from insulin doubled the body's own oxytocin levels.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma OT response to insulin-induced hypoglycaemia without L-NAME
    Study

    n = 6

    Comparator
    Basal levels
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Insulin-induced hypoglycaemia, however, enhanced plasma AVP and OT levels by two-fold in the absence of L-NAME and by four-fold in the presence of the NO synthase inhibitor (NOS).
    1 context sentence
    Summary · context
    six normal men were treated with placebo (normal saline) or the NO synthase inhibitor N,G-nitro-L-arginine methyl ester (L-NAME), given at doses (40 micrograms kg-1 injected plus 50 micrograms kg-1 infused i.v.) previously found to be unable to change blood pressure

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelNon-randomized trialOther

    In normal men, insulin-induced hypoglycaemia raised plasma OT four-fold in the presence of the NO synthase inhibitor L-NAME, more than without it.

    In plain wordsIn healthy men, a drug blocking nitric oxide made the body's own oxytocin rise four-fold during low blood sugar, more than without it.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma OT response to insulin-induced hypoglycaemia with L-NAME
    Study

    n = 6

    Comparator
    Hypoglycaemia without L-NAME
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Insulin-induced hypoglycaemia, however, enhanced plasma AVP and OT levels by two-fold in the absence of L-NAME and by four-fold in the presence of the NO synthase inhibitor (NOS).
    1 context sentence
    Summary · context
    six normal men were treated with placebo (normal saline) or the NO synthase inhibitor N,G-nitro-L-arginine methyl ester (L-NAME), given at doses (40 micrograms kg-1 injected plus 50 micrograms kg-1 infused i.v.) previously found to be unable to change blood pressure

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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