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Study · In vitro (cells) · 1994

3 results

Expression and down-regulation by retinoic acid of IGF binding protein-2 and -4 in medium from human neuroblastoma cells.

Bernardini S, Cianfarani S, Spagnoli A, Annicchiarico-Petruzzelli M, Melino G, Massoud R, Boscherini B, Finazzi-Agró A, Rosenfeld RG, Federici G

Journal of neuroendocrinology1 Aug 1994Cited by 17 (Europe PMC)

PMID7527270 (opens in a new tab)DOI10.1111/j.1365-2826.1994.tb00601.x (opens in a new tab)PepBankPUB-07527270
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human neuroblastoma cells, exogenous IGFs including Des(1‑3)IGF-I did not induce differentiation.

    In plain wordsIn cells, Des(1‑3)IGF-I did not induce neuroblastoma cell differentiation.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeCell differentiation
    Study

    humann: not reported in source

    SK-N-BE(2) neuroblastoma cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The addition of exogenous IGFs, which did not induce cell differentiation
    1 context sentence
    Summary · context
    We investigated, by Western ligand blotting (WLB), the presence of IGFBPs and their possible modulation by retinoic acid (RA), IGF-I, IGF-II and truncated Des(1-3)IGF-I in conditioned medium (CM) of the human neuroblastoma SK-N-BE(2) cell line.
  2. 02LabIn vitro (cells)Mechanism

    In human neuroblastoma cells, truncated IGF-I reduced the IGFBP-2 band to 45% of control after 72 h.

    In plain wordsIn cells, truncated IGF-I reduced IGFBP-2 to 45% of control after 72 h.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseIGFBP-2 band intensity
    Study

    humann: not reported in source

    SK-N-BE(2) neuroblastoma cells
    Comparator
    Control
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated · 72 hAs given in this study (human).

    Measurements

    IGFBP-2 band intensity
    45 % of control
    72 h

    Source sentences

    Summary
    except for the truncated form of IGF-I, which induced a marked decrease in both the 37 kDa and 25 kDa bands after 72 h incubation (45% and 18% of control, respectively).
    2 context sentences
    Summary · context
    We demonstrated the presence of two IGFBPs, with MW 37 kDa and 25 kDa. Following immunoprecipitation, they turned out to be IGFBP-2 and -4, respectively.
    Summary · context
    We investigated, by Western ligand blotting (WLB), the presence of IGFBPs and their possible modulation by retinoic acid (RA), IGF-I, IGF-II and truncated Des(1-3)IGF-I in conditioned medium (CM) of the human neuroblastoma SK-N-BE(2) cell line.
  3. 03LabIn vitro (cells)Mechanism

    In human neuroblastoma cells, truncated IGF-I reduced the IGFBP-4 band to 18% of control after 72 h.

    In plain wordsIn cells, truncated IGF-I reduced IGFBP-4 to 18% of control after 72 h.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseIGFBP-4 band intensity
    Study

    humann: not reported in source

    SK-N-BE(2) neuroblastoma cells
    Comparator
    Control
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated · 72 hAs given in this study (human).

    Measurements

    IGFBP-4 band intensity
    18 % of control
    72 h

    Source sentences

    Summary
    except for the truncated form of IGF-I, which induced a marked decrease in both the 37 kDa and 25 kDa bands after 72 h incubation (45% and 18% of control, respectively).
    2 context sentences
    Summary · context
    We demonstrated the presence of two IGFBPs, with MW 37 kDa and 25 kDa. Following immunoprecipitation, they turned out to be IGFBP-2 and -4, respectively.
    Summary · context
    We investigated, by Western ligand blotting (WLB), the presence of IGFBPs and their possible modulation by retinoic acid (RA), IGF-I, IGF-II and truncated Des(1-3)IGF-I in conditioned medium (CM) of the human neuroblastoma SK-N-BE(2) cell line.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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