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Study · Randomized controlled trial · n = 18 · 1994

7 results

Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men.

Taaffe DR, Pruitt L, Reim J, Hintz RL, Butterfield G, Hoffman AR, Marcus R

The Journal of clinical endocrinology and metabolism1 Nov 1994Cited by 142 (Europe PMC)

PMID7525633 (opens in a new tab)DOI10.1210/jcem.79.5.7525633 (opens in a new tab)PepBankPUB-07525633
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In elderly men undertaking strength training, rhGH had no effect on muscle strength relative to placebo throughout the study.

    In plain wordsIn elderly men undertaking strength training, rhGH did not improve muscle strength compared with placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeMuscle strength
    Study

    n = 18

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    0.02 mg/kg BW.day · sc · 10 weeksAs given in this study (human).

    Source sentences

    Summary
    rhGH had no effect on muscle strength at any time, and no systematic difference in muscle strength was observed between groups throughout the study.
    2 context sentences
    Summary · context
    Eighteen healthy elderly men (65-82 yr) initially underwent progressive weight training for 14 weeks to invoke a trained state.
    Summary · context
    Subjects were then randomized to receive either 0.02 mg/kg BW.day recombinant human GH (rhGH) or placebo, given sc, while undertaking a further 10 weeks of strength training.
  2. 02HumanNon-randomized trialEfficacy outcome

    In elderly men undertaking strength training, body weight did not change in either the rhGH or placebo group.

    In plain wordsIn elderly men undertaking strength training, body weight did not change in either the rhGH or placebo group.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeBody weight
    Study

    n = 18

    Comparator
    Placebo
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    0.02 mg/kg BW.day · sc · 10 weeksAs given in this study (human).

    Source sentences

    Summary
    Body weight did not change in either group, but lean body mass increased, and fat mass decreased (P < 0.05) in the rhGH group.
    2 context sentences
    Summary · context
    Eighteen healthy elderly men (65-82 yr) initially underwent progressive weight training for 14 weeks to invoke a trained state.
    Summary · context
    Subjects were then randomized to receive either 0.02 mg/kg BW.day recombinant human GH (rhGH) or placebo, given sc, while undertaking a further 10 weeks of strength training.
  3. 03HumanNon-randomized trialEfficacy outcome

    In elderly men undertaking strength training, rhGH increased IGF-I to 255 +/- 32 micrograms/L at week 15 (P < 0.001).

    In plain wordsIn elderly men undertaking strength training, rhGH increased blood IGF-I from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseIGF-I at week 15
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.02 mg/kg BW.day · sc · 10 weeksAs given in this study (human).

    Measurements

    IGF-I
    255 micrograms/L
    week 15
    SEM
    32 micrograms/L
    week 15

    Source sentences

    Summary
    In the rhGH group, IGF-I levels increased to 255 +/- 32 micrograms/L at week 15 and 218 +/- 21 micrograms/L at week 24 (P < 0.001).
    2 context sentences
    Summary · context
    Eighteen healthy elderly men (65-82 yr) initially underwent progressive weight training for 14 weeks to invoke a trained state.
    Summary · context
    Subjects were then randomized to receive either 0.02 mg/kg BW.day recombinant human GH (rhGH) or placebo, given sc, while undertaking a further 10 weeks of strength training.
  4. 04HumanNon-randomized trialEfficacy outcome

    In elderly men undertaking strength training, rhGH increased IGF-I to 218 +/- 21 micrograms/L at week 24 (P < 0.001).

    In plain wordsIn elderly men undertaking strength training, rhGH increased blood IGF-I from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseIGF-I at week 24
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.02 mg/kg BW.day · sc · 10 weeksAs given in this study (human).

    Measurements

    IGF-I
    218 micrograms/L
    week 24
    SEM
    21 micrograms/L
    week 24

    Source sentences

    Summary
    In the rhGH group, IGF-I levels increased to 255 +/- 32 micrograms/L at week 15 and 218 +/- 21 micrograms/L at week 24 (P < 0.001).
    2 context sentences
    Summary · context
    Eighteen healthy elderly men (65-82 yr) initially underwent progressive weight training for 14 weeks to invoke a trained state.
    Summary · context
    Subjects were then randomized to receive either 0.02 mg/kg BW.day recombinant human GH (rhGH) or placebo, given sc, while undertaking a further 10 weeks of strength training.
  5. 05HumanNon-randomized trialEfficacy outcome

    In elderly men undertaking strength training, IGF-binding protein-3 increased with rhGH (P < 0.05).

    In plain wordsIn elderly men undertaking strength training, rhGH increased an IGF-binding protein from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseIGF-binding protein-3
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.02 mg/kg BW.day · sc · 10 weeksAs given in this study (human).

    Source sentences

    Summary
    IGF-binding protein-3 also increased in the rhGH group (P < 0.05).
    2 context sentences
    Summary · context
    Eighteen healthy elderly men (65-82 yr) initially underwent progressive weight training for 14 weeks to invoke a trained state.
    Summary · context
    Subjects were then randomized to receive either 0.02 mg/kg BW.day recombinant human GH (rhGH) or placebo, given sc, while undertaking a further 10 weeks of strength training.
  6. 06HumanNon-randomized trialEfficacy outcome

    In elderly men undertaking strength training, lean body mass increased in the rhGH group (P < 0.05).

    In plain wordsIn elderly men undertaking strength training, lean body mass increased with rhGH.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseLean body mass
    Study

    n: not reported in source

    Outcome group
    Body composition · Musculoskeletal
    Studied dose
    0.02 mg/kg BW.day · sc · 10 weeksAs given in this study (human).

    Source sentences

    Summary
    Body weight did not change in either group, but lean body mass increased, and fat mass decreased (P < 0.05) in the rhGH group.
    2 context sentences
    Summary · context
    Eighteen healthy elderly men (65-82 yr) initially underwent progressive weight training for 14 weeks to invoke a trained state.
    Summary · context
    Subjects were then randomized to receive either 0.02 mg/kg BW.day recombinant human GH (rhGH) or placebo, given sc, while undertaking a further 10 weeks of strength training.
  7. 07HumanNon-randomized trialEfficacy outcome

    In elderly men undertaking strength training, fat mass decreased in the rhGH group (P < 0.05).

    In plain wordsIn elderly men undertaking strength training, fat mass decreased with rhGH.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseFat mass
    Study

    n: not reported in source

    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    0.02 mg/kg BW.day · sc · 10 weeksAs given in this study (human).

    Source sentences

    Summary
    Body weight did not change in either group, but lean body mass increased, and fat mass decreased (P < 0.05) in the rhGH group.
    2 context sentences
    Summary · context
    Eighteen healthy elderly men (65-82 yr) initially underwent progressive weight training for 14 weeks to invoke a trained state.
    Summary · context
    Subjects were then randomized to receive either 0.02 mg/kg BW.day recombinant human GH (rhGH) or placebo, given sc, while undertaking a further 10 weeks of strength training.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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