Skip to content

Study · Measured the body's own peptide · 1994

3 results

Elevated cerebrospinal fluid levels of oxytocin in obsessive-compulsive disorder. Comparison with Tourette's syndrome and healthy controls.

Leckman JF, Goodman WK, North WG, Chappell PB, Price LH, Pauls DL, Anderson GM, Riddle MA, McSwiggan-Hardin M, McDougle CJ

Archives of general psychiatry1 Oct 1994Cited by 136 (Europe PMC)

PMID7524462 (opens in a new tab)DOI10.1001/archpsyc.1994.03950100030003 (opens in a new tab)PepBankPUB-07524462
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    Cerebrospinal fluid oxytocin levels were increased in patients with OCD compared with patients with Tourette's syndrome and normal controls.

    In plain wordsIn people with OCD, the body's own oxytocin in spinal fluid was higher than in people with Tourette's syndrome or healthy people.

    Peptide
    Oxytocin
    Outcome
    IncreaseCSF oxytocin level in OCD
    Study

    n = 83

    Comparator
    Patients with Tourette's syndrome and normal controls
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    but increased oxytocin levels in patients with OCD.
    1 context sentence
    Summary · context
    To compare cerebrospinal fluid (CSF) levels of arginine vasopressin and oxytocin, we collected CSF at midday in a standardized fashion from a total of 83 individuals (29 patients with OCD, 23 patients with Tourette's syndrome, and 31 normal controls).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    The increase in CSF oxytocin was seen only in a subset of patients with OCD without a personal or family history of tic disorders.

    In plain wordsThe higher body's own oxytocin in spinal fluid was seen only in people with OCD who had no personal or family history of tics.

    Peptide
    Oxytocin
    Outcome
    IncreaseCSF oxytocin level in OCD without tic history
    Study

    n = 22

    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    Remarkably, this increase was observed only in a subset of patients with OCD (n = 22) independently identified as being without a personal or family history of tic disorders (P = .0003).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In patients with OCD without tic history, CSF oxytocin level was positively correlated with current OCD severity (r = .47).

    In plain wordsIn people with OCD and no tic history, higher natural oxytocin levels in spinal fluid were linked to more severe OCD.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation of CSF oxytocin with OCD severity
    Study

    n = 19

    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    In this subgroup of patients, the CSF oxytocin level was correlated with current severity of OCD (n = 19, r = .47, P < .05).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.