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Study · Not a test of the peptide alone · 1994

6 results

[Immunobiologic characteristics of hybrid proteins consisting of tumor necrosis factor alpha and thymosin alpha 1].

Shmelev VA, Khromykh LM, Dudich EI, Sheviakova LIa, Gorbatova EA, Galaktionov VG

Vestnik Rossiiskoi akademii meditsinskikh nauk1 Jan 1994

PMID7522706 (opens in a new tab)PepBankPUB-07522706
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    Thymosin alpha‑1-TNF hybrid proteins caused cell proliferation of the thymus, spleen and lymph nodes.

    In plain wordsIn animal tests, thymosin-TNF hybrid proteins made cells in immune organs multiply.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCell proliferation of thymus, spleen and lymph nodes
    Study

    n: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Hybrid proteins caused cell proliferation of the thymus, spleen, and lymph nodes

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    Thymosin alpha‑1-TNF hybrid proteins increased the expression of the thymocyte antigens H-2K, CD4 and CD8 to different degrees.

    In plain wordsIn animal tests, thymosin-TNF hybrid proteins raised thymus cell markers to different degrees.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseExpression of thymocyte antigens H-2K, CD4 and CD8
    Study

    n: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    H-2K, CD4, and CD8 differently increased the expression of thymocytic antigens.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 03AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    The preparations (thymosin alpha‑1, TNF and the hybrid proteins) had different effects on phagocytosis, antibody-forming cells, delayed reaction and natural killer cell activation.

    In plain wordsIn animal tests, thymosin, TNF and their hybrids affected several immune functions in different ways.

    Peptide
    Thymosin alpha-1
    Outcome
    MixedPhagocytosis, antibody-forming cells, delayed reaction and natural killer cell activation
    Study

    n: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The authors found the different effects of the drugs on phagocytosis, the production of antibody-forming cells, delayed reaction, and activation of natural killer cells.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  4. 04AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    The hybrid protein T-TNF-T produced the most pronounced action among the preparations tested.

    In plain wordsIn animal tests, the hybrid with thymosin on both ends of TNF had the strongest effect of the preparations.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableOverall immunobiological action of T-TNF-T
    Study

    n: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The protein T-TNF-T produced the most pronounced action.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  5. 05LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In L-929 cells, the thymosin alpha‑1-TNF hybrid T-TNF kept the cytotoxicity of TNF, TNF-T kept it at a lower level, and T-NTF-T was completely inactive.

    In plain wordsIn lab tests, one thymosin-TNF hybrid kept TNF's cell-killing effect, another kept less of it, and a third had none.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableCytotoxicity in L-929 cells
    Study

    n: not reported in source

    L-929 cells
    Outcome group
    Cell viability and death · Pharmacology

    Source sentences

    Summary
    In the L-929 cells, T-TNF preserved cytotoxicity unique to TNF; TNF-T preserved it 10 times less, and T-NTF-T was completely inactive.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  6. 06LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Efficacy outcome

    The thymosin alpha‑1-TNF hybrid TNF-T inhibited the growth of Molt-4, Jm-9 and Raji cells, while TNF alone suppressed only Raji cells.

    In plain wordsIn lab tests, a thymosin-TNF hybrid slowed the growth of three cell lines. TNF alone slowed only one of them.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseGrowth of Molt-4, Jm-9 and Raji cells
    Study

    n: not reported in source

    Molt-4, Jm-9 and Raji cells
    Comparator
    TNF
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    TNF-T inhibited the growth of Molt-4, Jm-9, Raji cells by 63 = 84%, and TNF suppressed only Raji cells by 50%.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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