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Study · In vitro (cells) · pig · 1994

3 results

Differential steroidogenic response of subpopulations of porcine granulosa cells to insulin-like growth factor-1 (IGF-1) or IGF-1 analogs.

Howard HJ, Ford JJ

Biology of reproduction1 Jul 1994Cited by 8 (Europe PMC)

PMID7522591 (opens in a new tab)DOI10.1095/biolreprod51.1.108 (opens in a new tab)PepBankPUB-07522591
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In tightly bound porcine granulosa cells, the IGF analogs including Long R3 stimulated estradiol production more potently than IGF-1 in experiment 1.

    In plain wordsIn pig ovary cells of the tightly bound type, the Long R3 IGF-1 analog stimulated estradiol production more strongly than IGF-1 in the first experiment.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseEstradiol production in experiment 1
    Study

    pign: not reported in source

    porcine granulosa cell subpopulations (tightly bound and weakly associated)
    Comparator
    IGF-1
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The IGF analogs were more potent stimulators than IGF-1 in experiment 1 (p < 0.05)
    2 context sentences
    Summary · context
    In tightly bound but not weakly associated cells, IGF-1 stimulated estradiol production.
    Summary · context
    Two experiments were conducted to examine responses of porcine granulosa cells to insulin-like growth factor-1 (IGF-1) or IGF-1 analogs (des [1-3] and Long R3) that have reduced affinity for IGF-binding proteins (IGFBP).
  2. 02LabIn vitro (cells)Activity measurement

    In tightly bound porcine granulosa cells in experiment 2, the greater potency of the IGF analogs than IGF-1 was restricted to cells collected 48 h after weaning.

    In plain wordsIn pig ovary cells, the analog worked better than IGF-1 only in cells collected 48 hours after weaning.

    Peptide
    IGF-1 LR3
    Outcome
    MixedEstradiol production in experiment 2 by time after weaning
    Study

    pign: not reported in source

    porcine granulosa cell subpopulations (tightly bound and weakly associated)
    Comparator
    IGF-1
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and in experiment 2, this response was restricted to cells collected at 48 h after weaning.
    1 context sentence
    Summary · context
    Two experiments were conducted to examine responses of porcine granulosa cells to insulin-like growth factor-1 (IGF-1) or IGF-1 analogs (des [1-3] and Long R3) that have reduced affinity for IGF-binding proteins (IGFBP).
  3. 03LabIn vitro (cells)Activity measurement

    In porcine granulosa cells exposed to IGF-1 or analogs, weakly associated cells produced more 28-30-kDa IGFBP than tightly bound cells.

    In plain wordsIn pig ovary cells treated with IGF-1 or its analogs, one cell type made more binding protein than the other.

    Peptide
    IGF-1 LR3
    Outcome
    Not applicable28-30-kDa IGFBP production by weakly associated versus tightly bound cells
    Study

    pign: not reported in source

    porcine granulosa cell subpopulations (tightly bound and weakly associated)
    Comparator
    tightly bound cells
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    During the final 48 h of culture, weakly associated cells produced greater quantities of 28-30-kDa IGFBP than did tightly bound cells in response to IGF-1 or analogs (both experiments; p < 0.05)
    1 context sentence
    Summary · context
    Two experiments were conducted to examine responses of porcine granulosa cells to insulin-like growth factor-1 (IGF-1) or IGF-1 analogs (des [1-3] and Long R3) that have reduced affinity for IGF-binding proteins (IGFBP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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