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Study · Animal study (in vivo) · lamb and sheep · 1994

10 results

Transfer of insulin-like growth factor (IGF)-I from blood to intestine: comparison with IGFs that bind poorly to IGF-binding proteins.

Lord AP, Martin AA, Ballard FJ, Read LC

The Journal of endocrinology1 Jun 1994Cited by 2 (Europe PMC)

PMID7520931 (opens in a new tab)DOI10.1677/joe.0.1410505 (opens in a new tab)PepBankPUB-07520931
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In anaesthetized lambs, net intestinal transfer of LR3IGF-I was very similar to that of IGF-I and des(1-3)IGF-I.

    In plain wordsIn lambs, the LR3 IGF-I analogue moved from blood into the gut about as much as IGF-I did.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeNet intestinal transfer of LR3IGF-I versus IGF-I
    Study

    lambn: not reported in source

    non-recirculating vascular-perfused distal small intestine
    Comparator
    IGF-I and des(1-3)IGF-I
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 ng/ml plasma · intra-arterial infusion into an intestinal segment · 45 minAs given in this study (lamb).

    Source sentences

    Summary
    Notwithstanding these marked differences in the plasma levels of free peptide, net intestinal transfer was very similar for the three peptides, as was the extent of degradation in the intestinal tissue.
    2 context sentences
    Summary · context
    The net transfer of 125I-labelled insulin-like growth factor (IGF)-I from the blood to the distal small intestine was measured in anaesthetized lambs using a non-recirculating vascular-perfused intestine.
    Summary · context
    To determine whether IGF-binding proteins (IGFBPs) reduce net IGF transfer, radiolabelled IGF-I was compared with two analogues, des(1-3)IGF-I and LR3IGF-I, which show reduced affinity for IGFBPs.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In anaesthetized lambs, the analogues including LR3IGF-I had up to ninefold higher free peptide in venous plasma of the perfused segment than IGF-I.

    In plain wordsIn lambs, the LR3 IGF-I analogue left much more free, unbound peptide in the blood leaving the gut than IGF-I did.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseFree radiolabelled peptide in venous plasma
    Study

    lambn: not reported in source

    non-recirculating vascular-perfused distal small intestine
    Comparator
    IGF-I
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 ng/ml plasma · intra-arterial infusion into an intestinal segment · 45 minAs given in this study (lamb).

    Source sentences

    Summary
    The analogues differed from IGF-I with up to ninefold higher concentrations of free radiolabelled peptide in venous plasma of the perfused intestinal segment, and corresponding decreases in binding to the 30-50 kDa binding proteins.
    2 context sentences
    Summary · context
    The net transfer of 125I-labelled insulin-like growth factor (IGF)-I from the blood to the distal small intestine was measured in anaesthetized lambs using a non-recirculating vascular-perfused intestine.
    Summary · context
    To determine whether IGF-binding proteins (IGFBPs) reduce net IGF transfer, radiolabelled IGF-I was compared with two analogues, des(1-3)IGF-I and LR3IGF-I, which show reduced affinity for IGFBPs.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In anaesthetized lambs, the analogues including LR3IGF-I showed decreased binding to the 30-50 kDa binding proteins compared with IGF-I.

    In plain wordsIn lambs, the LR3 IGF-I analogue bound less to the 30-50 kDa binding proteins than IGF-I did.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseBinding to 30-50 kDa binding proteins
    Study

    lambn: not reported in source

    non-recirculating vascular-perfused distal small intestine
    Comparator
    IGF-I
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 ng/ml plasma · intra-arterial infusion into an intestinal segment · 45 minAs given in this study (lamb).

    Source sentences

    Summary
    The analogues differed from IGF-I with up to ninefold higher concentrations of free radiolabelled peptide in venous plasma of the perfused intestinal segment, and corresponding decreases in binding to the 30-50 kDa binding proteins.
    2 context sentences
    Summary · context
    The net transfer of 125I-labelled insulin-like growth factor (IGF)-I from the blood to the distal small intestine was measured in anaesthetized lambs using a non-recirculating vascular-perfused intestine.
    Summary · context
    To determine whether IGF-binding proteins (IGFBPs) reduce net IGF transfer, radiolabelled IGF-I was compared with two analogues, des(1-3)IGF-I and LR3IGF-I, which show reduced affinity for IGFBPs.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In anaesthetized lambs, radiolabelled peptides including LR3IGF-I showed very little degradation in plasma and 3-10% degradation in intestinal tissue.

    In plain wordsIn lambs, very little of the labelled peptide, including LR3 IGF-I, broke down in plasma or gut tissue.

    Peptide
    IGF-1 LR3
    Outcome
    Not applicableDegradation in intestinal tissue
    Study

    lambn: not reported in source

    non-recirculating vascular-perfused distal small intestine
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 ng/ml plasma · intra-arterial infusion into an intestinal segment · 45 minAs given in this study (lamb).

    Measurements

    degradation in intestinal tissue
    3 to 10%
    intestinal tissue

    Source sentences

    Summary
    Very little degradation of radiolabelled peptides was detected in plasma, with 3-10% degradation in the intestinal tissue.
    2 context sentences
    Summary · context
    The net transfer of 125I-labelled insulin-like growth factor (IGF)-I from the blood to the distal small intestine was measured in anaesthetized lambs using a non-recirculating vascular-perfused intestine.
    Summary · context
    To determine whether IGF-binding proteins (IGFBPs) reduce net IGF transfer, radiolabelled IGF-I was compared with two analogues, des(1-3)IGF-I and LR3IGF-I, which show reduced affinity for IGFBPs.
  5. 05AnimalAnimal study (in vivo)Pharmacokinetics

    In lambs, net intestinal transfer of des(1‑3)IGF-I was very similar to that of IGF-I and LR3IGF-I.

    In plain wordsIn lambs, net transfer of des(1‑3)IGF-I to intestinal tissue, luminal contents and lymph was similar to IGF-I and LR3IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeNet intestinal transfer
    Study

    sheepn: not reported in source

    Anaesthetized lambs with vascular-perfused intestine
    Comparator
    IGF-I and LR3IGF-I
    Outcome group
    Pharmacokinetics · Gastrointestinal
    Studied dose
    1 ng/ml plasma · Infusion into the intestinal arterial supply · 45 minAs given in this study (sheep).

    Source sentences

    Summary
    Notwithstanding these marked differences in the plasma levels of free peptide, net intestinal transfer was very similar for the three peptides, as was the extent of degradation in the intestinal tissue.
    3 context sentences
    Summary · context
    Radiolabelled IGF-I, des(1-3)IGF-I or LR3IGF-I (1 ng/ml plasma) was infused for 45 min into the arterial supply of a 10 cm intestinal segment, either in the absence of added unlabelled peptide (high specific activity) or in the presence of a 100-fold excess of unlabelled homologous peptide (low spec…
    Summary · context
    The net transfer of 125I-labelled insulin-like growth factor (IGF)-I from the blood to the distal small intestine was measured in anaesthetized lambs using a non-recirculating vascular-perfused intestine.
    Summary · context
    To determine whether IGF-binding proteins (IGFBPs) reduce net IGF transfer, radiolabelled IGF-I was compared with two analogues, des(1-3)IGF-I and LR3IGF-I, which show reduced affinity for IGFBPs.
  6. 06AnimalAnimal study (in vivo)Pharmacokinetics

    In lambs, intestinal degradation of des(1‑3)IGF-I was very similar to that of IGF-I and LR3IGF-I.

    In plain wordsIn lambs, des(1‑3)IGF-I breakdown in intestinal tissue was similar to that of IGF-I and LR3IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeIntestinal tissue degradation
    Study

    sheepn: not reported in source

    Anaesthetized lambs with vascular-perfused intestine
    Comparator
    IGF-I and LR3IGF-I
    Outcome group
    Pharmacokinetics · Gastrointestinal
    Studied dose
    1 ng/ml plasma · Infusion into the intestinal arterial supply · 45 minAs given in this study (sheep).

    Source sentences

    Summary
    Notwithstanding these marked differences in the plasma levels of free peptide, net intestinal transfer was very similar for the three peptides, as was the extent of degradation in the intestinal tissue.
    3 context sentences
    Summary · context
    Radiolabelled IGF-I, des(1-3)IGF-I or LR3IGF-I (1 ng/ml plasma) was infused for 45 min into the arterial supply of a 10 cm intestinal segment, either in the absence of added unlabelled peptide (high specific activity) or in the presence of a 100-fold excess of unlabelled homologous peptide (low spec…
    Summary · context
    The net transfer of 125I-labelled insulin-like growth factor (IGF)-I from the blood to the distal small intestine was measured in anaesthetized lambs using a non-recirculating vascular-perfused intestine.
    Summary · context
    To determine whether IGF-binding proteins (IGFBPs) reduce net IGF transfer, radiolabelled IGF-I was compared with two analogues, des(1-3)IGF-I and LR3IGF-I, which show reduced affinity for IGFBPs.

Studies that did not test the peptide alone4

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 07AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Pharmacokinetics

    In lambs, pooled radiolabelled IGF peptides including des(1‑3)IGF-I showed very little degradation in plasma.

    In plain wordsIn lambs, pooled labelled IGF peptides including des(1‑3)IGF-I showed very little breakdown in plasma.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Direction not reportedPlasma degradation of pooled radiolabelled peptides
    Study

    sheepn: not reported in source

    Anaesthetized lambs with vascular-perfused intestine
    Outcome group
    Pharmacokinetics · Gastrointestinal

    Source sentences

    Summary
    Very little degradation of radiolabelled peptides was detected in plasma, with 3-10% degradation in the intestinal tissue.
    3 context sentences
    Summary · context
    Radiolabelled IGF-I, des(1-3)IGF-I or LR3IGF-I (1 ng/ml plasma) was infused for 45 min into the arterial supply of a 10 cm intestinal segment, either in the absence of added unlabelled peptide (high specific activity) or in the presence of a 100-fold excess of unlabelled homologous peptide (low spec…
    Summary · context
    The net transfer of 125I-labelled insulin-like growth factor (IGF)-I from the blood to the distal small intestine was measured in anaesthetized lambs using a non-recirculating vascular-perfused intestine.
    Summary · context
    To determine whether IGF-binding proteins (IGFBPs) reduce net IGF transfer, radiolabelled IGF-I was compared with two analogues, des(1-3)IGF-I and LR3IGF-I, which show reduced affinity for IGFBPs.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  2. 08AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Pharmacokinetics

    In lambs, pooled radiolabelled IGF peptides including des(1‑3)IGF-I showed degradation in intestinal tissue.

    In plain wordsIn lambs, pooled labelled IGF peptides including des(1‑3)IGF-I showed some breakdown in intestinal tissue.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Direction not reportedIntestinal degradation of pooled radiolabelled peptides
    Study

    sheepn: not reported in source

    Anaesthetized lambs with vascular-perfused intestine
    Outcome group
    Pharmacokinetics · Gastrointestinal

    Measurements

    Intestinal tissue degradation
    3 to 10%
    radiolabelled peptides

    Source sentences

    Summary
    Very little degradation of radiolabelled peptides was detected in plasma, with 3-10% degradation in the intestinal tissue.
    3 context sentences
    Summary · context
    Radiolabelled IGF-I, des(1-3)IGF-I or LR3IGF-I (1 ng/ml plasma) was infused for 45 min into the arterial supply of a 10 cm intestinal segment, either in the absence of added unlabelled peptide (high specific activity) or in the presence of a 100-fold excess of unlabelled homologous peptide (low spec…
    Summary · context
    The net transfer of 125I-labelled insulin-like growth factor (IGF)-I from the blood to the distal small intestine was measured in anaesthetized lambs using a non-recirculating vascular-perfused intestine.
    Summary · context
    To determine whether IGF-binding proteins (IGFBPs) reduce net IGF transfer, radiolabelled IGF-I was compared with two analogues, des(1-3)IGF-I and LR3IGF-I, which show reduced affinity for IGFBPs.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  3. 09AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Pharmacokinetics

    In lambs, pooled IGF analogues including des(1‑3)IGF-I had higher free venous peptide concentrations than IGF-I.

    In plain wordsIn lambs, pooled IGF analogues including des(1‑3)IGF-I had more free peptide in venous blood than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseFree venous peptide concentrations of pooled analogues
    Study

    sheepn: not reported in source

    Anaesthetized lambs with vascular-perfused intestine
    Comparator
    IGF-I
    Outcome group
    Pharmacokinetics · Gastrointestinal

    Source sentences

    Summary
    The analogues differed from IGF-I with up to ninefold higher concentrations of free radiolabelled peptide in venous plasma of the perfused intestinal segment, and corresponding decreases in binding to the 30-50 kDa binding proteins.
    2 context sentences
    Summary · context
    The net transfer of 125I-labelled insulin-like growth factor (IGF)-I from the blood to the distal small intestine was measured in anaesthetized lambs using a non-recirculating vascular-perfused intestine.
    Summary · context
    To determine whether IGF-binding proteins (IGFBPs) reduce net IGF transfer, radiolabelled IGF-I was compared with two analogues, des(1-3)IGF-I and LR3IGF-I, which show reduced affinity for IGFBPs.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  4. 10AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Pharmacokinetics

    In lambs, pooled IGF analogues including des(1‑3)IGF-I bound less to the smaller plasma binding proteins than IGF-I.

    In plain wordsIn lambs, pooled IGF analogues including des(1‑3)IGF-I bound less to smaller plasma proteins than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseBinding to smaller plasma proteins by pooled analogues
    Study

    sheepn: not reported in source

    Anaesthetized lambs with vascular-perfused intestine
    Comparator
    IGF-I
    Outcome group
    Pharmacokinetics · Gastrointestinal

    Source sentences

    Summary
    The analogues differed from IGF-I with up to ninefold higher concentrations of free radiolabelled peptide in venous plasma of the perfused intestinal segment, and corresponding decreases in binding to the 30-50 kDa binding proteins.
    2 context sentences
    Summary · context
    The net transfer of 125I-labelled insulin-like growth factor (IGF)-I from the blood to the distal small intestine was measured in anaesthetized lambs using a non-recirculating vascular-perfused intestine.
    Summary · context
    To determine whether IGF-binding proteins (IGFBPs) reduce net IGF transfer, radiolabelled IGF-I was compared with two analogues, des(1-3)IGF-I and LR3IGF-I, which show reduced affinity for IGFBPs.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    21 Oct 2026, 13:52 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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