In rats with suppressed lactation, Long-R3-IGF-I did not reinitiate lactation, whereas prolactin and GH did.
In plain wordsIn rats with suppressed milk production, the LR3 IGF-I analogue did not restart lactation, while prolactin and growth hormone did.
- Peptide
- IGF-1 LR3
- Outcome
- No significant changeReinitiation of lactation
- Study
ratn: not reported in source
lactation suppressed by bromocriptine and anti-GH antiserum- Comparator
- prolactin and GH
- Outcome group
- Sex hormones and fertility · Reproductive and sexual health
- Studied dose
- Dose not stated
Source sentences
However, none was effective in reinitiating lactation, even at doses which have been shown to be biologically effective in terms of nitrogen retention.(ABSTRACT TRUNCATED AT 250 WORDS)
3 context sentences(design, population, supporting numbers)
we also tested three IGF-I analogues, R3-IGF-I, Long-IGF-I and Long-R3-IGF-I.
Despite the fact that all treatments except prolactin led to increases in serum IGFs and IGFBP-3, only prolactin and GH provoked the reinitiation of milk production as determined by increased litter weight gain, milk in the stomach of pups and a significant increase in the weight of the mammary glands.
Lactation was suppressed in rats using a combined treatment of bromocriptine (to reduce prolactin concentrations) and a specific antiserum to rat GH administered twice daily for 2 days.