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Study · In vitro (cells) · bovine · 1993

8 results

Effects of insulin-like growth factor-I and its analogues on bovine hydrogen peroxide release by neutrophils and blastogenesis by mononuclear cells.

Zhao X, McBride BW, Trouten-Radford LM, Burton JH

The Journal of endocrinology1 Nov 1993Cited by 5 (Europe PMC)

PMID7508487 (opens in a new tab)DOI10.1677/joe.0.1390259 (opens in a new tab)PepBankPUB-07508487
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In bovine neutrophils, preincubation with long R3 IGF-I increased the release of H2O2 by 32% compared with control.

    In plain wordsIn cow immune cells, the long R3 IGF-I analogue increased hydrogen peroxide release compared with untreated cells.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseHydrogen peroxide release by neutrophils at 12.5 micrograms/l
    Study

    bovinen: not reported in source

    bovine neutrophils and mononuclear cells
    Comparator
    control without IGF-I
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    12.5 micrograms/lAs given in this study (bovine).

    Measurements

    H2O2 release increase
    32%
    long R3 IGF-I 12.5 micrograms/l

    Source sentences

    Summary
    increased the release of H2O2 by 65%, 64% and 32% respectively.
    2 context sentences
    Summary · context
    Relative to control treatment containing no IGF-I, preincubation of neutrophils with 12.5 micrograms/l of IGF-I
    Summary · context
    The biological potencies of recombinant human insulin-like growth factor-I (IGF-I) and two of its analogues were examined for hydrogen peroxide release by neutrophils and blastogenesis by mononuclear cells.
  2. 02LabIn vitro (cells)Activity measurement

    In bovine neutrophils, the difference in H2O2 release between long R3 IGF-I and IGF-I or des(1-3)IGF-I was reduced at 100 micrograms/l.

    In plain wordsIn cow immune cells, at a higher dose the gap in hydrogen peroxide release between the long R3 IGF-I analogue and the other peptides shrank.

    Peptide
    IGF-1 LR3
    Outcome
    Not applicableHydrogen peroxide release at 100 micrograms/l versus IGF-I and des(1-3)IGF-I
    Study

    bovinen: not reported in source

    bovine neutrophils and mononuclear cells
    Comparator
    IGF-I and des(1-3)IGF-I
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    100 micrograms/lAs given in this study (bovine).

    Source sentences

    Summary
    However, the difference in stimulating the release of H2O2 between long R3 IGF-I and other two (IGF-I and des(1-3)IGF-I) was reduced at a dosage of 100 micrograms/l.
    1 context sentence
    Summary · context
    The biological potencies of recombinant human insulin-like growth factor-I (IGF-I) and two of its analogues were examined for hydrogen peroxide release by neutrophils and blastogenesis by mononuclear cells.
  3. 03LabIn vitro (cells)Activity measurement

    In bovine mononuclear cells, long R3 IGF-I at 100 micrograms/l did not significantly stimulate thymidine incorporation, with or without 2.5% FCS, unlike IGF-I and des(1-3)IGF-I.

    In plain wordsIn cow immune cells, the long R3 IGF-I analogue did not significantly stimulate cell growth, while IGF-I and the des(1-3) analogue did.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeThymidine incorporation into mononuclear cells
    Study

    bovinen: not reported in source

    bovine neutrophils and mononuclear cells
    Comparator
    IGF-I and des(1-3)IGF-I
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    100 micrograms/lAs given in this study (bovine).

    Source sentences

    Summary
    In the absence or presence of 2.5% fetal calf serum (FCS), 100 micrograms/l of IGF-I, des(1-3)IGF-I but not long R3 IGF-I significantly stimulated thymidine incorporation into mononuclear cells.
    1 context sentence
    Summary · context
    The biological potencies of recombinant human insulin-like growth factor-I (IGF-I) and two of its analogues were examined for hydrogen peroxide release by neutrophils and blastogenesis by mononuclear cells.
  4. 04LabIn vitro (cells)Activity measurement

    In bovine neutrophils, des(1‑3)IGF-I increased hydrogen peroxide release by 64% versus no IGF-I.

    In plain wordsIn cells, des(1‑3)IGF-I increased hydrogen peroxide release compared with no IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseHydrogen peroxide release
    Study

    bovinen: not reported in source

    bovine neutrophils
    Comparator
    No IGF-I control
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    12.5 micrograms/lAs given in this study (bovine).

    Measurements

    H2O2 release increase
    64%
    des(1-3)IGF-I versus no IGF-I

    Source sentences

    Summary
    increased the release of H2O2 by 65%, 64% and 32% respectively.
    3 context sentences
    Summary · context
    Relative to control treatment containing no IGF-I, preincubation of neutrophils with 12.5 micrograms/l of IGF-I, des(1-3)IGF-I
    Summary · context
    The biological potencies of recombinant human insulin-like growth factor-I (IGF-I) and two of its analogues were examined for hydrogen peroxide release by neutrophils and blastogenesis by mononuclear cells.
    Summary · context
    The binding affinities of these peptides for bovine serum IGF-binding proteins (IGFBPs) and IGF-I receptors on bovine neutrophils and mononuclear cells were also investigated.
  5. 05LabIn vitro (cells)Activity measurement

    In bovine neutrophils, the difference in hydrogen peroxide stimulation between des(1‑3)IGF-I and long R3 IGF-I narrowed at the higher dosage.

    In plain wordsIn cells, the difference in hydrogen peroxide stimulation between des(1‑3)IGF-I and long R3 IGF-I narrowed at the higher dosage.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseDifference in hydrogen peroxide stimulation
    Study

    bovinen: not reported in source

    bovine neutrophils
    Comparator
    long R3 IGF-I
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    100 micrograms/lAs given in this study (bovine).

    Source sentences

    Summary
    However, the difference in stimulating the release of H2O2 between long R3 IGF-I and other two (IGF-I and des(1-3)IGF-I) was reduced at a dosage of 100 micrograms/l.
    2 context sentences
    Summary · context
    The biological potencies of recombinant human insulin-like growth factor-I (IGF-I) and two of its analogues were examined for hydrogen peroxide release by neutrophils and blastogenesis by mononuclear cells.
    Summary · context
    The binding affinities of these peptides for bovine serum IGF-binding proteins (IGFBPs) and IGF-I receptors on bovine neutrophils and mononuclear cells were also investigated.
  6. 06LabIn vitro (cells)Activity measurement

    In bovine mononuclear cells without fetal calf serum, des(1‑3)IGF-I significantly stimulated thymidine incorporation.

    In plain wordsIn cells without fetal calf serum, des(1‑3)IGF-I increased thymidine incorporation.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseThymidine incorporation without fetal calf serum
    Study

    bovinen: not reported in source

    bovine mononuclear cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    100 micrograms/lAs given in this study (bovine).

    Source sentences

    Summary
    In the absence or presence of 2.5% fetal calf serum (FCS), 100 micrograms/l of IGF-I, des(1-3)IGF-I but not long R3 IGF-I significantly stimulated thymidine incorporation into mononuclear cells.
    2 context sentences
    Summary · context
    The biological potencies of recombinant human insulin-like growth factor-I (IGF-I) and two of its analogues were examined for hydrogen peroxide release by neutrophils and blastogenesis by mononuclear cells.
    Summary · context
    The binding affinities of these peptides for bovine serum IGF-binding proteins (IGFBPs) and IGF-I receptors on bovine neutrophils and mononuclear cells were also investigated.
  7. 07LabIn vitro (cells)Activity measurement

    In bovine mononuclear cells with fetal calf serum, des(1‑3)IGF-I significantly stimulated thymidine incorporation.

    In plain wordsIn cells with fetal calf serum, des(1‑3)IGF-I increased thymidine incorporation.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseThymidine incorporation with fetal calf serum
    Study

    bovinen: not reported in source

    bovine mononuclear cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    100 micrograms/lAs given in this study (bovine).

    Source sentences

    Summary
    In the absence or presence of 2.5% fetal calf serum (FCS), 100 micrograms/l of IGF-I, des(1-3)IGF-I but not long R3 IGF-I significantly stimulated thymidine incorporation into mononuclear cells.
    2 context sentences
    Summary · context
    The biological potencies of recombinant human insulin-like growth factor-I (IGF-I) and two of its analogues were examined for hydrogen peroxide release by neutrophils and blastogenesis by mononuclear cells.
    Summary · context
    The binding affinities of these peptides for bovine serum IGF-binding proteins (IGFBPs) and IGF-I receptors on bovine neutrophils and mononuclear cells were also investigated.
  8. 08LabIn vitro (cells)Activity measurement

    In bovine mononuclear cells with fetal calf serum, des(1‑3)IGF-I stimulated thymidine incorporation more potently than IGF-I.

    In plain wordsIn cells with fetal calf serum, des(1‑3)IGF-I stimulated thymidine incorporation more potently than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreasePotency for thymidine incorporation with serum
    Study

    bovinen: not reported in source

    bovine mononuclear cells
    Comparator
    IGF-I
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, des(1-3)IGF-I was more potent than IGF-I in stimulating thymidine incorporation into mononuclear cells in the presence of 2.5% FCS.(ABSTRACT TRUNCATED AT 250 WORDS)
    2 context sentences
    Summary · context
    The biological potencies of recombinant human insulin-like growth factor-I (IGF-I) and two of its analogues were examined for hydrogen peroxide release by neutrophils and blastogenesis by mononuclear cells.
    Summary · context
    The binding affinities of these peptides for bovine serum IGF-binding proteins (IGFBPs) and IGF-I receptors on bovine neutrophils and mononuclear cells were also investigated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    21 Oct 2026, 13:52 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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