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Study · In vitro (cells) · pig · 1994

1 result

Proteolytic degradation of insulin-like growth factor (IGF)-binding protein-3 by porcine ovarian granulosa cells in culture: regulation by IGF-I.

Grimes RW, Hammond JM

Endocrinology1 Jan 1994Cited by 36 (Europe PMC)

PMID7506209 (opens in a new tab)DOI10.1210/endo.134.1.7506209 (opens in a new tab)PepBankPUB-07506209
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured porcine granulosa cells, long R3 IGF-I attenuated IGFBP-3 degradation even though it has low affinity for IGFBPs.

    In plain wordsIn pig ovarian cells in the lab, long R3 IGF-I slowed the breakdown of IGFBP-3.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseDegradation of IGFBP-3
    Study

    pign: not reported in source

    Porcine ovarian granulosa cells in culture
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, long R3 IGF-I attenuated IGFBP-3 degradation even though it has low affinity for IGFBPs.
    1 context sentence
    Summary · context
    The purpose of the present study was to determine whether IGFBP-3 levels were also regulated via proteolysis.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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