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Study · In vitro (cells) · 1993

4 results

Insulin-like growth factor (IGF) suppression of IGFBP-1 production: evidence for mediation by the type I IGF receptor.

Lee PD, Suwanichkul A, DePaolis LA, Snuggs MB, Morris SL, Powell DR

Regulatory peptides1 Oct 1993Cited by 18 (Europe PMC)

PMID7505466 (opens in a new tab)DOI10.1016/0167-0115(93)90348-c (opens in a new tab)PepBankPUB-07505466
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In HepG2 human hepatoma cells, long R3IGF-I potently suppressed the increase in IGFBP-1 protein levels induced by cAMP and theophylline.

    In plain wordsIn human liver cancer cells, the long R3 IGF-I analogue strongly reduced the rise in IGFBP-1 protein caused by cAMP and theophylline.

    Peptide
    IGF-1 LR3
    Outcome
    DecreasecAMP and theophylline-induced IGFBP-1 protein levels
    Study

    humann: not reported in source

    HepG2 human hepatoma cells
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-I, IGF-II, and IGF-analogs with low IGFBP-1 affinity, (des 1-3)IGF-I and long R3IGF-I, all potently suppressed the previously characterized increase in IGFBP-1 protein levels and promoter activity induced by cAMP and theophylline.
    1 context sentence
    Summary · context
    The regulation of insulin-like growth factor binding protein-1 (IGFBP-1) by its ligands, IGF-I and IGF-II, was studied in continuous cultures of HepG2 human hepatoma cells.
  2. 02LabIn vitro (cells)Mechanism

    In HepG2 human hepatoma cells, long R3IGF-I potently suppressed the increase in IGFBP-1 promoter activity induced by cAMP and theophylline.

    In plain wordsIn human liver cancer cells, the long R3 IGF-I analogue strongly reduced the rise in IGFBP-1 promoter activity caused by cAMP and theophylline.

    Peptide
    IGF-1 LR3
    Outcome
    DecreasecAMP and theophylline-induced IGFBP-1 promoter activity
    Study

    humann: not reported in source

    HepG2 human hepatoma cells
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-I, IGF-II, and IGF-analogs with low IGFBP-1 affinity, (des 1-3)IGF-I and long R3IGF-I, all potently suppressed the previously characterized increase in IGFBP-1 protein levels and promoter activity induced by cAMP and theophylline.
    1 context sentence
    Summary · context
    The regulation of insulin-like growth factor binding protein-1 (IGFBP-1) by its ligands, IGF-I and IGF-II, was studied in continuous cultures of HepG2 human hepatoma cells.
  3. 03LabIn vitro (cells)Mechanism

    In HepG2 cells, des(1‑3)IGF-I suppressed the increase in IGFBP-1 protein induced by cAMP and theophylline.

    In plain wordsIn cells, des(1‑3)IGF-I reduced IGFBP-1 protein compared with cAMP and theophylline stimulation.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseStimulated IGFBP-1 protein levels
    Study

    humann: not reported in source

    HepG2 human hepatoma cells
    Comparator
    cAMP and theophylline stimulation
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-I, IGF-II, and IGF-analogs with low IGFBP-1 affinity, (des 1-3)IGF-I and long R3IGF-I, all potently suppressed the previously characterized increase in IGFBP-1 protein levels and promoter activity induced by cAMP and theophylline.
    1 context sentence
    Summary · context
    The regulation of insulin-like growth factor binding protein-1 (IGFBP-1) by its ligands, IGF-I and IGF-II, was studied in continuous cultures of HepG2 human hepatoma cells.
  4. 04LabIn vitro (cells)Mechanism

    In HepG2 cells, des(1‑3)IGF-I suppressed the increase in IGFBP-1 promoter activity induced by cAMP and theophylline.

    In plain wordsIn cells, des(1‑3)IGF-I reduced IGFBP-1 promoter activity compared with cAMP and theophylline stimulation.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseStimulated IGFBP-1 promoter activity
    Study

    humann: not reported in source

    HepG2 human hepatoma cells
    Comparator
    cAMP and theophylline stimulation
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-I, IGF-II, and IGF-analogs with low IGFBP-1 affinity, (des 1-3)IGF-I and long R3IGF-I, all potently suppressed the previously characterized increase in IGFBP-1 protein levels and promoter activity induced by cAMP and theophylline.
    1 context sentence
    Summary · context
    The regulation of insulin-like growth factor binding protein-1 (IGFBP-1) by its ligands, IGF-I and IGF-II, was studied in continuous cultures of HepG2 human hepatoma cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    21 Oct 2026, 13:52 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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