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Study · Animal study (in vivo) · cat · 1995

4 results

Effect of acadesine treatment on postischemic damage to small intestine.

Schoenberg MH, Poch B, Moch D, Marzinzig M, Marzinzig E, Mattfeldt T, Gruber H, Beger HG

The American journal of physiology1 Nov 1995Cited by 12 (Europe PMC)

PMID7503274 (opens in a new tab)DOI10.1152/ajpheart.1995.269.5.h1752 (opens in a new tab)PepBankPUB-07503274
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In cats with intestinal ischemia, acadesine reduced mucosal lesions during reperfusion versus saline.

    In plain wordsIn cats with intestinal ischemia, acadesine reduced intestinal lining damage during restored blood flow compared with saline.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMucosal lesions during reperfusion
    Study

    catn = 12

    Intestinal ischemia and reperfusion
    Comparator
    Saline
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    2.5 mg/kg over 5 min, then 0.5 mg.kg-1.min- · intravenous · Before ischemia through 30 min after reperfusionAs given in this study (cat).

    Source sentences

    Summary
    Acadesine treatment significantly attenuated the mucosal lesions seen during reperfusion.
    3 context sentences
    Summary · context
    Intestinal ischemia was induced in cats by partial occlusion of the superior mesenteric artery for 2 h.
    Summary · context
    Six cats received saline, and six cats were treated initially before ischemia with acadesine (2.5 mg/kg body wt i.v.) over 5 min as a bolus.
    Summary · context
    Thereafter, acadesine (0.5 mg.kg-1.min- i.v.) was given continuously during ischemia and 30 min after reperfusion.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In cats with intestinal ischemia, acadesine inhibited neutrophil accumulation versus saline.

    In plain wordsIn cats with intestinal ischemia, acadesine reduced neutrophil accumulation compared with saline.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNeutrophil accumulation
    Study

    catn = 12

    Intestinal ischemia and reperfusion
    Comparator
    Saline
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    2.5 mg/kg over 5 min, then 0.5 mg.kg-1.min- · intravenous · Before ischemia through 30 min after reperfusionAs given in this study (cat).

    Source sentences

    Summary
    This improvement was due at least in part to the inhibition of neutrophil accumulation, as judged by low myeloperoxidase levels.
    3 context sentences
    Summary · context
    Intestinal ischemia was induced in cats by partial occlusion of the superior mesenteric artery for 2 h.
    Summary · context
    Six cats received saline, and six cats were treated initially before ischemia with acadesine (2.5 mg/kg body wt i.v.) over 5 min as a bolus.
    Summary · context
    Thereafter, acadesine (0.5 mg.kg-1.min- i.v.) was given continuously during ischemia and 30 min after reperfusion.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In cats with intestinal ischemia, acadesine treatment was associated with low intestinal myeloperoxidase levels versus saline.

    In plain wordsIn cats with intestinal ischemia, acadesine treatment showed lower intestinal myeloperoxidase levels compared with saline.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMyeloperoxidase levels
    Study

    catn = 12

    Intestinal ischemia and reperfusion
    Comparator
    Saline
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    2.5 mg/kg over 5 min, then 0.5 mg.kg-1.min- · intravenous · Before ischemia through 30 min after reperfusionAs given in this study (cat).

    Source sentences

    Summary
    This improvement was due at least in part to the inhibition of neutrophil accumulation, as judged by low myeloperoxidase levels.
    3 context sentences
    Summary · context
    Intestinal ischemia was induced in cats by partial occlusion of the superior mesenteric artery for 2 h.
    Summary · context
    Six cats received saline, and six cats were treated initially before ischemia with acadesine (2.5 mg/kg body wt i.v.) over 5 min as a bolus.
    Summary · context
    Thereafter, acadesine (0.5 mg.kg-1.min- i.v.) was given continuously during ischemia and 30 min after reperfusion.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In cats, acadesine-associated prevention of neutrophil activation most likely reflected increased intestinal adenosine during early reperfusion.

    In plain wordsIn cats, higher intestinal adenosine most likely contributed to acadesine-associated prevention of neutrophil activation during early restored blood flow.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseIntestinal adenosine concentrations
    Study

    catn = 12

    Intestinal ischemia and reperfusion
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    2.5 mg/kg over 5 min, then 0.5 mg.kg-1.min- · intravenous · Before ischemia through 30 min after reperfusionAs given in this study (cat).

    Source sentences

    Summary
    The prevention of neutrophil activation resulted most likely from increased adenosine concentrations in the intestinal tissue in the early reperfusion period.(ABSTRACT TRUNCATED AT 250 WORDS)
    3 context sentences
    Summary · context
    Intestinal ischemia was induced in cats by partial occlusion of the superior mesenteric artery for 2 h.
    Summary · context
    Six cats received saline, and six cats were treated initially before ischemia with acadesine (2.5 mg/kg body wt i.v.) over 5 min as a bolus.
    Summary · context
    Thereafter, acadesine (0.5 mg.kg-1.min- i.v.) was given continuously during ischemia and 30 min after reperfusion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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