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Study · In vitro (cells) · hamster · 1995

2 results

Similarities between hamster pancreatic islet beta (HIT) cell vasopressin receptors and V1b receptors.

Richardson SB, Laya T, VanOoy M

The Journal of endocrinology1 Oct 1995Cited by 13 (Europe PMC)

PMID7490538 (opens in a new tab)DOI10.1677/joe.0.1470059 (opens in a new tab)PepBankPUB-07490538
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In hamster HIT beta cells, oxytocin was less potent than vasopressin and arginine-vasotocin, and more potent than dDAVP, in stimulating insulin secretion and inositol phosphate production.

    In plain wordsIn cells, oxytocin was weaker than vasopressin at triggering insulin release, but stronger than one other vasopressin drug.

    Peptide
    Oxytocin
    Outcome
    Not applicablePotency to stimulate insulin secretion and inositol phosphate production
    Study

    hamstern: not reported in source

    HIT pancreatic beta cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The relative orders of potency of VP analogues were parallel in both respects: desamino-Arg-VP (dAVP) > Arg-vasotocin (AVT) = VP > oxytocin (OXY) > desamino-D-Arg-VP (dDAVP) > d(D-3-Pal)VP. dAVP, the most potent agonist tested, behaved as a V1 but non-V1a agonist.
    1 context sentence
    Summary · context
    We have further pharmacologically characterized HIT cell VP receptors by comparing the potencies of a series of VP agonists including the novel V1b agonist, desamino(D-3-(3'-pyridyl)-Ala2,Arg8)VP (d(D-3-Pal)VP), in stimulating insulin secretion and inositol phosphate (IP) production.
  2. 02LabIn vitro (cells)Activity measurement

    In hamster HIT cell monolayers, oxytocin had lower affinity than vasopressin for competing with [3H]AVP binding, and higher affinity than dDAVP.

    In plain wordsIn cells, oxytocin attached to vasopressin receptors less strongly than vasopressin did, but more strongly than one other vasopressin drug.

    Peptide
    Oxytocin
    Outcome
    Not applicableBinding affinity for vasopressin receptors in HIT cell monolayers
    Study

    hamstern: not reported in source

    HIT pancreatic beta cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In HIT cell monolayers, the relative order of affinity of analogues in competition for binding with [3H]AVP was: dAVP > AVT = VP > V1a antagonist > OXY > dDAVP > V2 antagonist = d(D-3-Pal)VP, in parallel with their biological activity.
    1 context sentence
    Summary · context
    We have further pharmacologically characterized HIT cell VP receptors by comparing the potencies of a series of VP agonists including the novel V1b agonist, desamino(D-3-(3'-pyridyl)-Ala2,Arg8)VP (d(D-3-Pal)VP), in stimulating insulin secretion and inositol phosphate (IP) production.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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