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Study · In vitro (cells) · 1980

5 results

Glycyl-L-histidyl-L-lysine, a growth promoting factor for human cells.

Williams MV, Cheng Y

Cytobios1 Jan 1980Cited by 3 (Europe PMC)

PMID7418444 (opens in a new tab)PepBankPUB-07418444
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human KB cells in serum limited medium containing BSA, GHL stimulated growth.

    In plain wordsIn cells, GHL increased growth of human KB cells in serum limited medium containing BSA.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    IncreaseKB cell growth
    Study

    humann: not reported in source

    KB cells in serum limited medium containing BSA
    Outcome group
    Cell proliferation and differentiation · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHL was found to stimulate the growth of human KB, and HeLa cells, but not WI-38 cells when employed in serum limited medium containing bovine serum albumin (BSA).
    1 context sentence
    Summary · context
    The growth promoting activity of a synthesis tripeptide, glycyl-L-histidyl-L-lysine (GHL) as a possible serum substitute was determined using human KB cells.
  2. 02LabIn vitro (cells)Efficacy outcome

    In human HeLa cells in serum limited medium containing BSA, GHL stimulated growth.

    In plain wordsIn cells, GHL increased growth of human HeLa cells in serum limited medium containing BSA.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    IncreaseHeLa cell growth
    Study

    humann: not reported in source

    HeLa cells in serum limited medium containing BSA
    Outcome group
    Cell proliferation and differentiation · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHL was found to stimulate the growth of human KB, and HeLa cells, but not WI-38 cells when employed in serum limited medium containing bovine serum albumin (BSA).
    1 context sentence
    Summary · context
    The growth promoting activity of a synthesis tripeptide, glycyl-L-histidyl-L-lysine (GHL) as a possible serum substitute was determined using human KB cells.
  3. 03LabIn vitro (cells)Efficacy outcome

    In human WI-38 cells in serum limited medium containing BSA, GHL did not stimulate growth.

    In plain wordsIn cells, GHL did not increase growth of human WI-38 cells in serum limited medium containing BSA.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    No significant changeWI-38 cell growth
    Study

    humann: not reported in source

    WI-38 cells in serum limited medium containing BSA
    Outcome group
    Cell proliferation and differentiation · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHL was found to stimulate the growth of human KB, and HeLa cells, but not WI-38 cells when employed in serum limited medium containing bovine serum albumin (BSA).
    1 context sentence
    Summary · context
    The growth promoting activity of a synthesis tripeptide, glycyl-L-histidyl-L-lysine (GHL) as a possible serum substitute was determined using human KB cells.

Studies that did not test the peptide alone2

In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  1. 04LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cells)Efficacy outcome

    In human cells, growth in GHL and BSA medium was similar to growth in medium containing 5% serum.

    In plain wordsIn cells, growth with GHL and BSA was similar to growth with 5% serum.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    No significant changeCell growth rate versus serum
    Study

    humann: not reported in source

    human cells in GHL and BSA medium
    Comparator
    Medium containing 5% serum
    Outcome group
    Cell proliferation and differentiation · Cancer

    Source sentences

    Summary
    The rate of growth of cells in this medium was similar to that of cells grown in medium containing 5% serum.
    2 context sentences
    Summary · context
    GHL was found to stimulate the growth of human KB, and HeLa cells, but not WI-38 cells when employed in serum limited medium containing bovine serum albumin (BSA).
    Summary · context
    The growth promoting activity of a synthesis tripeptide, glycyl-L-histidyl-L-lysine (GHL) as a possible serum substitute was determined using human KB cells.

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  2. 05LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cells)Activity measurement

    In human cells, synthetic peptides of similar composition interfered with GHL growth-promoting activity.

    In plain wordsIn cells, similar synthetic peptides interfered with GHL growth-promoting activity.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    DecreaseInterference with GHL growth activity
    Study

    humann: not reported in source

    human cells
    Outcome group
    Cell proliferation and differentiation · Cancer

    Source sentences

    Summary
    The growth promoting activity was specific for GHL; other synthetic peptides which were similar in composition had no activity, but they did interfere with the growth promoting activity of GHL.
    1 context sentence
    Summary · context
    The growth promoting activity of a synthesis tripeptide, glycyl-L-histidyl-L-lysine (GHL) as a possible serum substitute was determined using human KB cells.

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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