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Study · Non-randomized trial · 1980

4 results

Prolonged biphasic response of plasma testosterone to single intramuscular injections of human chorionic gonadotropin.

Padrón RS, Wischusen J, Hudson B, Burger HG, de Kretser DM

The Journal of clinical endocrinology and metabolism1 Jun 1980Cited by 69 (Europe PMC)

PMID7372789 (opens in a new tab)DOI10.1210/jcem-50-6-1100 (opens in a new tab)PepBankPUB-07372789
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In normal men, hCG produced an initial testosterone rise at 2 h and a secondary peak at 48 h.

    In plain wordsIn normal men, testosterone rose at 2 h and reached a second peak at 48 h after hCG.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseBiphasic plasma testosterone response
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0--6000 IU single injection · intramuscularAs given in this study (human).

    Measurements

    Time of initial plasma testosterone rise
    2 h
    after single im hCG injection
    Time to secondary testosterone peak
    48 h
    after single im hCG injection

    Source sentences

    Summary
    After an initial rise at 2 h, the levels of testosterone demonstrated a secondary rise, reaching a peak 48 h after the im injection.
    1 context sentence
    Summary · context
    The response of plasma testosterone to varying doses of hCG (0--6000 IU) given as a single im injection has been evaluated in normal men.
  2. 02HumanNon-randomized trialEfficacy outcome

    In normal men, the magnitude of the testosterone response increased with hCG dose.

    In plain wordsIn normal men, higher hCG doses produced larger testosterone responses.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseDose-dependent testosterone response
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0--6000 IU single injection · intramuscularAs given in this study (human).

    Source sentences

    Summary
    The magnitude of the response varied directly with the dose of hCG used, and at the highest dose (6000 IU) testosterone levels were still elevated 6 days after administration.
    1 context sentence
    Summary · context
    The response of plasma testosterone to varying doses of hCG (0--6000 IU) given as a single im injection has been evaluated in normal men.
  3. 03HumanNon-randomized trialEfficacy outcome

    In normal men, testosterone remained elevated 6 days after a single 6000 IU hCG injection.

    In plain wordsIn normal men, testosterone remained elevated 6 days after a single 6000 IU hCG injection.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreasePersistent testosterone elevation
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    6000 IU single injection · intramuscularAs given in this study (human).

    Measurements

    Time testosterone remained elevated after dose
    6 days
    6000 IU hCG, single im injection

    Source sentences

    Summary
    The magnitude of the response varied directly with the dose of hCG used, and at the highest dose (6000 IU) testosterone levels were still elevated 6 days after administration.
    1 context sentence
    Summary · context
    The response of plasma testosterone to varying doses of hCG (0--6000 IU) given as a single im injection has been evaluated in normal men.
  4. 04HumanNon-randomized trialEfficacy outcome

    In normal men, estradiol showed a dose-dependent rise and peaked 24 h after hCG.

    In plain wordsIn normal men, estradiol rose with hCG dose and peaked 24 h after treatment.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreasePlasma estradiol response
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0--6000 IU single injection · intramuscularAs given in this study (human).

    Measurements

    Time to peak plasma estradiol
    24 h
    after hCG

    Source sentences

    Summary
    Plasma estradiol levels showed a dose-dependent rise, with peak levels being attained 24 h after hCG.
    1 context sentence
    Summary · context
    The response of plasma testosterone to varying doses of hCG (0--6000 IU) given as a single im injection has been evaluated in normal men.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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