In vitro stimulation of prolactin release by vasoactive intestinal peptide.

Samson WK, Said SI, Snyder G, McCann SM

Peptides1 Jan 1980Cited by 53 (Europe PMC)

PMID7301635DOI10.1016/0196-9781(80)90010-8PepBankPUB-07301635

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In male rat hemipituitaries, synthetic VIP stimulated prolactin release at doses as low as 10-9 M, but only when bacitracin was present in the medium.
In plain wordsIn lab tests on rat pituitary tissue, synthetic VIP increased prolactin release, but only when an enzyme inhibitor was present.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseProlactin release from male rat hemipituitaries (synthetic VIP)
Study
ratn: not reported in source
male rat hemipituitaries in vitro, with bacitracin
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
as low as 10-9MAs given in this study (rat).
Source sentences
Summary
Synthetic VIP was capable of stimulating increased prolactin (PRL) release from male rat hemipituitaries in doses as low as 10-9M only when the enzyme inhibitor bacitracin was present in the incubation medium.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of vasoactive intestinal peptide (VIP) on anterior pituitary hormone release was examined in a variety of in vitro preparations.
Report a problemFND-0730163501
02LabEx vivo tissueEfficacy outcome
In male rat hemipituitaries, natural porcine VIP also stimulated prolactin release, but only at the higher dose of 10-6 M.
In plain wordsIn lab tests on rat pituitary tissue, natural pig VIP also increased prolactin release, but only at a much higher dose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseProlactin release from male rat hemipituitaries (natural porcine VIP)
Study
ratn: not reported in source
male rat hemipituitaries in vitro
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10-6MAs given in this study (rat).
Source sentences
Summary
Natural porcine VIP was similarly capable of stimulating PRL release, but only at higher doses (10-6M).
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of vasoactive intestinal peptide (VIP) on anterior pituitary hormone release was examined in a variety of in vitro preparations.
Report a problemFND-0730163502
03LabEx vivo tissueEfficacy outcome
In in vitro rat pituitary preparations, VIP had no effect on luteinizing hormone release.
In plain wordsIn lab tests on rat pituitary tissue, VIP did not change release of luteinizing hormone.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeLuteinizing hormone release
Study
ratn: not reported in source
in vitro rat anterior pituitary preparations
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
No effect of VIP on luteinizing hormone, growth hormone or thyroid stimulating hormone release was seen.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of vasoactive intestinal peptide (VIP) on anterior pituitary hormone release was examined in a variety of in vitro preparations.
Report a problemFND-0730163504
04LabEx vivo tissueEfficacy outcome
In in vitro rat pituitary preparations, VIP had no effect on growth hormone release.
In plain wordsIn lab tests on rat pituitary tissue, VIP did not change release of growth hormone.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeGrowth hormone release
Study
ratn: not reported in source
in vitro rat anterior pituitary preparations
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
No effect of VIP on luteinizing hormone, growth hormone or thyroid stimulating hormone release was seen.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of vasoactive intestinal peptide (VIP) on anterior pituitary hormone release was examined in a variety of in vitro preparations.
Report a problemFND-0730163505
05LabEx vivo tissueEfficacy outcome
In in vitro rat pituitary preparations, VIP had no effect on thyroid stimulating hormone release.
In plain wordsIn lab tests on rat pituitary tissue, VIP did not change release of thyroid stimulating hormone.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeThyroid stimulating hormone release
Study
ratn: not reported in source
in vitro rat anterior pituitary preparations
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
No effect of VIP on luteinizing hormone, growth hormone or thyroid stimulating hormone release was seen.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of vasoactive intestinal peptide (VIP) on anterior pituitary hormone release was examined in a variety of in vitro preparations.
Report a problemFND-0730163506
06LabIn vitro (cells)Efficacy outcome
In dispersed rat anterior pituitary cells and in enriched lactotrophs, synthetic VIP stimulated prolactin release.
In plain wordsIn lab tests on rat pituitary cells, synthetic VIP increased prolactin release.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseProlactin release from dispersed anterior pituitary cells and enriched lactotrophs
Study
ratn: not reported in source
dispersed anterior pituitary cells from adult male and lactating female rats, and enriched lactotrophs from infantile female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Additionally, synthetic VIP was capable of stimulating PRL release from dispersed anterior pituitary cells harvested from adult male and lactating female rats and from an enriched population of lactotrophs obtained by unit gravity sedimentation of similar dispersed cells from infantile female rats.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of vasoactive intestinal peptide (VIP) on anterior pituitary hormone release was examined in a variety of in vitro preparations.
Report a problemFND-0730163503

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

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