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Study · Animal study (in vivo) · rat · 1981

2 results

Disposition of morphine in rat brain: relationship to biological activity.

Plomp GJ, Maes RA, van Ree JM

The Journal of pharmacology and experimental therapeutics1 Apr 1981Cited by 23 (Europe PMC)

PMID7205651 (opens in a new tab)DOI10.1016/s0022-3565(25)32510-3 (opens in a new tab)PepBankPUB-07205651
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, PLG pretreatment decreased brain morphine levels at 3 hr after morphine injection.

    In plain wordsIn rats, PLG pretreatment lowered brain morphine levels at 3 hr after morphine injection.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseBrain morphine levels
    Study

    ratn: not reported in source

    morphine exposure
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with the tripeptide prolyl-leucyl-glycinamide, which facilitates development of morphine tolerance, decreased brain morphine levels and increased plasma levels at 3 hr after morphine injection.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, PLG pretreatment increased plasma morphine levels at 3 hr after morphine injection.

    In plain wordsIn rats, PLG pretreatment raised plasma morphine levels at 3 hr after morphine injection.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreasePlasma morphine levels
    Study

    ratn: not reported in source

    morphine exposure
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with the tripeptide prolyl-leucyl-glycinamide, which facilitates development of morphine tolerance, decreased brain morphine levels and increased plasma levels at 3 hr after morphine injection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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