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Study · Animal study (in vivo) · mouse · 1980

4 results

Effect of long-term treatment with circulating thymic factor on murine lupus.

Bach MA, Droz D, Noel LH, Blanchard D, Dardenne M, Peking A

Arthritis and rheumatism1 Dec 1980Cited by 7 (Europe PMC)

PMID7192987 (opens in a new tab)DOI10.1002/art.1780231204 (opens in a new tab)PepBankPUB-07192987
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In NZB and B/W mice, FTS completely prevented or cured autoimmune sialoadenoitis.

    In plain wordsIn NZB and B/W mice, FTS prevented or cured autoimmune salivary gland inflammation.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseAutoimmune sialoadenoitis
    Study

    mousen: not reported in source

    NZB and B/W lupus-like disease
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The autoimmune sialoadenoitis (Sjögren's syndrome) appearing in NZB and B/W mice, evaluated here by a scintigraphic method, was completely prevented or even cured by FTS treatment.
    1 context sentence
    Summary · context
    Mice from three different strains (NZB, B/W, and Swan) which spontaneously develop a lupus-like disease and show a premature decline of their secretion of the circulating thymic factor, Facteur Thymique Sérique (FTS), were treated repeatedly with FTS and followed for the evolution of their autoimmune disease.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aged NZB mice, FTS transiently delayed the increase in anti-erythrocyte autoantibody production.

    In plain wordsIn aged NZB mice, FTS briefly delayed the increase in antibodies against red blood cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseAnti-erythrocyte autoantibody production
    Study

    mousen: not reported in source

    aged NZB mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The increase in anti-erythrocyte autoantibody production was transiently delayed in aged NZB mice.
    1 context sentence
    Summary · context
    Mice from three different strains (NZB, B/W, and Swan) which spontaneously develop a lupus-like disease and show a premature decline of their secretion of the circulating thymic factor, Facteur Thymique Sérique (FTS), were treated repeatedly with FTS and followed for the evolution of their autoimmune disease.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In lupus-prone mice, FTS left antiDNA antibody production unaffected in an unspecified strain subset.

    In plain wordsIn lupus-prone mice, FTS did not change antiDNA antibody production in some mice.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeAntiDNA antibody production unaffected
    Study

    mousen: not reported in source

    murine lupus
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Conversely, antiDNA antibody production either remained unaffected or was accelerated (in B/W mice) by FTS treatment.
    1 context sentence
    Summary · context
    Mice from three different strains (NZB, B/W, and Swan) which spontaneously develop a lupus-like disease and show a premature decline of their secretion of the circulating thymic factor, Facteur Thymique Sérique (FTS), were treated repeatedly with FTS and followed for the evolution of their autoimmune disease.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In B/W mice, FTS accelerated antiDNA antibody production.

    In plain wordsIn B/W mice, FTS accelerated production of antibodies against DNA.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseAntiDNA antibody production acceleration
    Study

    mousen: not reported in source

    B/W mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Conversely, antiDNA antibody production either remained unaffected or was accelerated (in B/W mice) by FTS treatment.
    1 context sentence
    Summary · context
    Mice from three different strains (NZB, B/W, and Swan) which spontaneously develop a lupus-like disease and show a premature decline of their secretion of the circulating thymic factor, Facteur Thymique Sérique (FTS), were treated repeatedly with FTS and followed for the evolution of their autoimmune disease.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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