Evidence of the presence in normal serum of a carrier of the serum thymic factor (FTS).

Dardenne M, Pléau JM, Bach JF

European journal of immunology1 Feb 1980Cited by 21 (Europe PMC)

PMID7189463DOI10.1002/eji.1830100203PepBankPUB-07189463

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In thymectomized mice, injection of synthetic FTS induced both serum activity peaks.
In plain wordsIn mice without a thymus, injected synthetic FTS induced both serum activity peaks.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseRestoration of serum activity peaks
Study
mousen: not reported in source
thymectomized mice
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · injectionAs given in this study (mouse).
Source sentences
Summary
Both peaks were absent in serum of thymectomized (Tx) mice but could be induced in such Tx mice by injection of synthetic FTS.
Report a problemFND-0718946304

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

02AnimalEndogenous levelAnimal study (in vivo)Mechanism
In thymectomized mice, both serum FTS-like activity peaks were absent.
In plain wordsIn mice without a thymus, both serum activity peaks associated with natural FTS were absent.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseSerum activity peaks after thymectomy
Study
mousen: not reported in source
thymectomized mice
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
Both peaks were absent in serum of thymectomized (Tx) mice but could be induced in such Tx mice by injection of synthetic FTS.
This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0718946303
03LabEndogenous levelIn vitro (cell-free)Mechanism
In normal human and mouse serum, chromatography revealed two peaks of natural FTS-like rosette assay activity.
In plain wordsIn lab tests, human and mouse serum showed two activity peaks associated with natural FTS.
Peptide
Thymulin (serum thymic factor)
Outcome
Not applicableSerum activity peaks
Study
human and mousen: not reported in source
serum chromatography and rosette assay
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
Chromatography of normal human or mouse serum on Sephadex G-150 revealed the presence of two peaks of activity in the rosette assay used for the characterization of the serum thymic factor (FTS).
This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0718946301
04LabEndogenous levelIn vitro (cell-free)Mechanism
In serum, one activity peak matched FTS and the other corresponded to molecules of 40 000-60 000 molecular weight.
In plain wordsIn lab tests, natural FTS activity appeared in a small-molecule fraction and a larger-molecule fraction.
Peptide
Thymulin (serum thymic factor)
Outcome
Not applicableMolecular weights of activity fractions
Study
human and mousen: not reported in source
serum chromatography and rosette assay
Outcome group
Pharmacokinetics · Pharmacology
Measurements
molecular weight
867
FTS fraction
Source sentences
Summary
One peak corresponded to the elution volume of FTS (mol. wt. 867), the other to molecules with mol. wts. of 40 000-60 000.
This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0718946302

Studies that did not test the peptide alone1

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

05LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cell-free)Mechanism
In serum binding experiments, FTS bound a carrier with molecular weight near that of albumin or prealbumin.
In plain wordsIn lab tests, FTS bound a serum carrier similar in molecular weight to albumin or prealbumin.
Peptide
Thymulin (serum thymic factor)
Outcome
Not applicableSerum carrier binding
Study
n: not reported in source
serum chromatography and rosette assay
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
Study of the biological half-life of both peaks (assessed by the rosette assay) and demonstration of their specific retention on anti-FTS immunosorbent indicate, altogether with direct binding experiments, that FTS is transported in serum by a molecule with a mol. wt. of the order of that of albumin or prealbumin.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0718946305

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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