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Study · In vitro (cell-free) · 1982

2 results

A specific cytosolic estrogen receptor in human term placenta.

Kneussl ES, Ances IG, Albrecht ED

American journal of obstetrics and gynecology1 Dec 1982Cited by 11 (Europe PMC)

PMID7148904 (opens in a new tab)DOI10.1016/0002-9378(82)90356-8 (opens in a new tab)PepBankPUB-07148904
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Activity measurement

    In human placental cytosol, enclomiphene competed for estradiol binding in the receptor peak.

    In plain wordsIn lab tests, enclomiphene competed with estradiol for binding in human placental extracts.

    Peptide
    Enclomiphene
    Outcome
    DecreaseCompetition for estradiol binding
    Study

    humann: not reported in source

    Human term placental cytosol
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A single peak of [3H]E2 binding occurred in the 5.2 S region after glycerol density gradient centrifugation, which was competed for by DES, E2, and enclomiphene.
    1 context sentence
    Summary · context
    Villous tissue of human, term placentas was homogenized in 0.01M Tris-HCl, ethylenediaminetetraacetic acid, dithiothreitol, glycerol buffer.
  2. 02LabIn vitro (cell-free)Activity measurement

    In human placental cytosol, enclomiphene competed for estradiol binding less strongly than DES, estradiol, estrone and MER-25.

    In plain wordsIn lab tests, enclomiphene competed for placental estradiol binding less strongly than DES, estradiol, estrone and MER-25.

    Peptide
    Enclomiphene
    Outcome
    DecreaseRelative estradiol-binding competition
    Study

    humann: not reported in source

    Human term placental cytosol
    Comparator
    DES, estradiol, estrone and MER-25
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Competition for [3H]E2 binding was DES greater than E2 greater than estrone greater than MER-25 greater than enclomiphene, whereas androgens, progestins, and corticosteroids were ineffective.
    1 context sentence
    Summary · context
    Villous tissue of human, term placentas was homogenized in 0.01M Tris-HCl, ethylenediaminetetraacetic acid, dithiothreitol, glycerol buffer.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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