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Study · Animal study (in vivo) · rat · 1982

4 results

Effects of dermorphin on gastrointestinal transit in rats.

Broccardo M, Improta G, Nargi M, Melchiorri P

Regulatory peptides1 Jul 1982Cited by 19 (Europe PMC)

PMID7122927 (opens in a new tab)DOI10.1016/0167-0115(82)90099-4 (opens in a new tab)PepBankPUB-07122927
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular dermorphin delayed gastric emptying in a dose-dependent manner.

    In plain wordsIn rats, brain injections of dermorphin slowed stomach emptying, with a dose-dependent effect.

    Peptide
    Dermorphin
    Outcome
    DecreaseGastric emptying
    Study

    ratn: not reported in source

    rats
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Dermorphin injected i.c.v. delayed gastric emptying and this effect was dose-dependent.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.) and intracerebroventricular (i.c.v.) injections of dermorphin on gastric emptying and intestinal transit were studied in rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular dermorphin inhibited intestinal transit at doses higher than those active on gastric emptying.

    In plain wordsIn rats, brain injections of dermorphin slowed intestinal transit at higher doses than those needed to slow stomach emptying.

    Peptide
    Dermorphin
    Outcome
    DecreaseIntestinal transit
    Study

    ratn: not reported in source

    rats
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Measurements

    Dose relative to gastric emptying-active dose
    5 to 10 times
    intestinal transit inhibition

    Source sentences

    Summary
    I.c.v. injections of dermorphin also inhibited intestinal transit but a dose level 5 to 10 times higher than that active on gastric emptying was required.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.) and intracerebroventricular (i.c.v.) injections of dermorphin on gastric emptying and intestinal transit were studied in rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, subcutaneous dermorphin inhibited gastric emptying, with inhibition not exceeding 60%.

    In plain wordsIn rats, dermorphin injections under the skin slowed stomach emptying, with inhibition no greater than 60%.

    Peptide
    Dermorphin
    Outcome
    DecreaseGastric emptying
    Study

    ratn: not reported in source

    rats
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Subcutaneous injections of dermorphin also inhibited gastrointestinal transit but inhibition of the two functions never exceeded 60%.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.) and intracerebroventricular (i.c.v.) injections of dermorphin on gastric emptying and intestinal transit were studied in rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, subcutaneous dermorphin inhibited intestinal transit, with inhibition not exceeding 60%.

    In plain wordsIn rats, dermorphin injections under the skin slowed intestinal transit, with inhibition no greater than 60%.

    Peptide
    Dermorphin
    Outcome
    DecreaseIntestinal transit
    Study

    ratn: not reported in source

    rats
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Subcutaneous injections of dermorphin also inhibited gastrointestinal transit but inhibition of the two functions never exceeded 60%.
    1 context sentence
    Summary · context
    The effects of subcutaneous (s.c.) and intracerebroventricular (i.c.v.) injections of dermorphin on gastric emptying and intestinal transit were studied in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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