In C57BL/6 mice with a transplantable tumor, intravenous injection of bone marrow cells preincubated with thymosin alpha‑1 gave the same retarded tumor growth as thymosin fraction V.
In plain wordsIn mice, bone marrow cells pre-treated with thymosin alpha‑1 slowed tumor growth, as thymosin fraction V did.
- Peptide
- Thymosin alpha-1
- Outcome
- DecreaseTumor growth after thymosin alpha-1 treated bone marrow cell injection
- Study
mousen: not reported in source
C57BL/6 mice with 3-methylcholanthrene-induced transplantable tumor- Outcome group
- Tumor growth · Cancer
- Studied dose
- Dose not stated · intravenousAs given in this study (mouse).
Source sentences
The results showed significantly retarded tumor growth (P less than 0.001) and prolonged survival time (P less than 0.001) when thymosin fraction V was used. The same results were obtained with thymosin alpha-1 with use of the same protocol but only one-twentieth of the concentration of fraction V.
1 context sentence(design, population, supporting numbers)
The effect of iv injection in C57BL/6 mice of 3X10(7) bone marrow cells preincubated in either thymosin fraction V or thymosin alpha-1 was evaluated on the growth of a 3-methylcholanthrene-induced transplantable tumor in a syngeneic system.