Neural regulation of gastric acid secretion in rats: influence of dermorphin.

Improta G, Broccardo M, Lisi A, Melchiorri P

Regulatory peptides1 Mar 1982Cited by 15 (Europe PMC)

PMID7043664DOI10.1016/0167-0115(82)90130-6PepBankPUB-07043664

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In pylorus-ligated rats, intracerebroventricular dermorphin dose-dependently suppressed water distension-stimulated gastric acid output.
In plain wordsIn rats, brain injections of dermorphin reduced stomach acid output stimulated by water distension, with a dose-dependent effect.
Peptide
Dermorphin
Outcome
DecreaseWater distension-stimulated gastric acid output
Study
ratn: not reported in source
conscious pylorus-ligated rats
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
threshold 5 pmol . kg-1 · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Dermorphin injected i.c.v. suppressed the stimulation of gastric acid output by gastric water distension and this effect is dose-dependent, the threshold dose being 5 pmol . kg-1.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of subcutaneous (s.c.) and intracerebroventricular (i.c.v.) injections of dermorphin on gastric acid output both basal and stimulated by water distension of the stomach, insulin or histamine injections, were studied in conscious pylorus-ligated rats.
Report a problemFND-0704366401
02AnimalAnimal study (in vivo)Efficacy outcome
In pylorus-ligated rats, dermorphin partially blocked insulin-stimulated gastric secretion.
In plain wordsIn rats, dermorphin partly blocked stomach secretion stimulated by insulin.
Peptide
Dermorphin
Outcome
DecreaseInsulin-stimulated gastric secretion
Study
ratn: not reported in source
conscious pylorus-ligated rats
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
Insulin stimulated gastric secretion is partially blocked by the peptide.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of subcutaneous (s.c.) and intracerebroventricular (i.c.v.) injections of dermorphin on gastric acid output both basal and stimulated by water distension of the stomach, insulin or histamine injections, were studied in conscious pylorus-ligated rats.
Report a problemFND-0704366402
03AnimalAnimal study (in vivo)Efficacy outcome
In pylorus-ligated rats, subcutaneous dermorphin inhibited basal gastric secretion.
In plain wordsIn rats, dermorphin injections under the skin reduced basal stomach secretion.
Peptide
Dermorphin
Outcome
DecreaseBasal gastric secretion
Study
ratn: not reported in source
conscious pylorus-ligated rats
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
625 nmol . kg-1 · subcutaneousAs given in this study (rat).
Source sentences
Summary
Subcutaneous injections of dermorphin, at a dose of 625 nmol . kg-1, inhibited basal and water distension-induced gastric secretion.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of subcutaneous (s.c.) and intracerebroventricular (i.c.v.) injections of dermorphin on gastric acid output both basal and stimulated by water distension of the stomach, insulin or histamine injections, were studied in conscious pylorus-ligated rats.
Report a problemFND-0704366403
04AnimalAnimal study (in vivo)Efficacy outcome
In pylorus-ligated rats, subcutaneous dermorphin inhibited water distension-induced gastric secretion.
In plain wordsIn rats, dermorphin injections under the skin reduced stomach secretion stimulated by water distension.
Peptide
Dermorphin
Outcome
DecreaseWater distension-induced gastric secretion
Study
ratn: not reported in source
conscious pylorus-ligated rats
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
625 nmol . kg-1 · subcutaneousAs given in this study (rat).
Source sentences
Summary
Subcutaneous injections of dermorphin, at a dose of 625 nmol . kg-1, inhibited basal and water distension-induced gastric secretion.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of subcutaneous (s.c.) and intracerebroventricular (i.c.v.) injections of dermorphin on gastric acid output both basal and stimulated by water distension of the stomach, insulin or histamine injections, were studied in conscious pylorus-ligated rats.
Report a problemFND-0704366404
05AnimalAnimal study (in vivo)Efficacy outcome
In pylorus-ligated rats, intracerebroventricular dermorphin did not affect histamine-induced gastric secretion.
In plain wordsIn rats, brain injections of dermorphin did not affect stomach secretion stimulated by histamine.
Peptide
Dermorphin
Outcome
No significant changeHistamine-induced gastric secretion
Study
ratn: not reported in source
conscious pylorus-ligated rats
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Injections (i.c.v.) of dermorphin were ineffective on histamine-induced gastric secretion.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of subcutaneous (s.c.) and intracerebroventricular (i.c.v.) injections of dermorphin on gastric acid output both basal and stimulated by water distension of the stomach, insulin or histamine injections, were studied in conscious pylorus-ligated rats.
Report a problemFND-0704366405

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

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MeSH terms

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