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Study · Measured the body's own peptide · 1981

5 results

Identification of human thymic epithelial cells with antibodies to thymosin alpha 1 in myasthenia gravis.

Dalakas MC, Engel WK, McClure JE, Goldstein AL, Askanas V

Annals of the New York Academy of Sciences1 Jan 1981Cited by 16 (Europe PMC)

PMID7041758 (opens in a new tab)DOI10.1111/j.1749-6632.1981.tb33754.x (opens in a new tab)PepBankPUB-07041758
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelEx vivo tissueOther

    In cultured thymus from three patients with myasthenia gravis, epithelial cells but not fibroblasts stained brightly for the body's own thymosin alpha‑1.

    In plain wordsIn cultured myasthenia gravis thymus, epithelial cells but not fibroblasts stained for the body's own thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableAlpha 1 staining in cultured thymus cells
    Study

    humann = 3

    Human thymus tissue sections
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    In cultured thymuses from three MG patients, epithelial cells but not fibroblasts were brightly stained for alpha 1.
    1 context sentence
    Summary · context
    Using anti-alpha 1 antibodies, we applied indirect immunofluorescence to human normal thymus of different ages and to hyperplastic, thymomatous, and "involuted" thymus of myasthenia gravis (MG) patients.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelEx vivo tissueOther

    In human thymus tissue, immunofluorescence located the body's own thymosin alpha‑1 only in epithelial cells.

    In plain wordsIn human thymus tissue, the body's own thymosin alpha‑1 was found only in thymic epithelial cells.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableCellular localization of thymosin alpha 1 in thymus
    Study

    humann: not reported in source

    Human thymus tissue sections
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    Alpha 1 was localized only in the epithelial cells, lying singly, grouped, in Hassell's corpuscles, and proliferated in thymomas.
    1 context sentence
    Summary · context
    Using anti-alpha 1 antibodies, we applied indirect immunofluorescence to human normal thymus of different ages and to hyperplastic, thymomatous, and "involuted" thymus of myasthenia gravis (MG) patients.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelEx vivo tissueOther

    In myasthenia gravis thymus, more epithelial cells stained strongly for the body's own thymosin alpha‑1 than in normal thymus, most clearly in thymomas.

    In plain wordsIn myasthenia gravis thymus tissue, more cells showed strong staining for the body's own thymosin alpha‑1 than in normal thymus.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseNumber and staining strength of alpha 1-positive epithelial cells in MG thymus versus normal thymus
    Study

    humann: not reported in source

    Human thymus tissue sections
    Comparator
    Normal thymus
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    Whereas normal thymuses and fewer and weakly stained cells, MG thymuses had many strongly positive epithelial cells; this was more evident in thymomas.
    1 context sentence
    Summary · context
    Using anti-alpha 1 antibodies, we applied indirect immunofluorescence to human normal thymus of different ages and to hyperplastic, thymomatous, and "involuted" thymus of myasthenia gravis (MG) patients.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelEx vivo tissueOther

    In thymus tissue from myasthenia gravis patients, germinal centers did not stain for the body's own thymosin alpha‑1.

    In plain wordsIn myasthenia gravis thymus tissue, germinal centers showed no staining for the body's own thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeAlpha 1 staining in germinal centers
    Study

    humann: not reported in source

    Human thymus tissue sections
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    Germinal centers were unstained.
    1 context sentence
    Summary · context
    Using anti-alpha 1 antibodies, we applied indirect immunofluorescence to human normal thymus of different ages and to hyperplastic, thymomatous, and "involuted" thymus of myasthenia gravis (MG) patients.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  5. 05LabEndogenous levelEx vivo tissueOther

    In involuted thymus from myasthenia gravis patients, small islands of brightly stained cells for the body's own thymosin alpha‑1 lay among fatty tissue.

    In plain wordsIn involuted myasthenia gravis thymus tissue, small groups of cells stained brightly for the body's own thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableAlpha 1 staining in involuted MG thymus
    Study

    humann: not reported in source

    Human thymus tissue sections
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    "Involuted" MG thymuses had small islands of brightly stained cells lying among the fatty tissue.
    1 context sentence
    Summary · context
    Using anti-alpha 1 antibodies, we applied indirect immunofluorescence to human normal thymus of different ages and to hyperplastic, thymomatous, and "involuted" thymus of myasthenia gravis (MG) patients.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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