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Study · Non-randomized trial · n = 12 · 1982

7 results

Both human pituitary growth hormone and recombinant DNA-derived human growth hormone cause insulin resistance at a postreceptor site.

Rosenfeld RG, Wilson DM, Dollar LA, Bennett A, Hintz RL

The Journal of clinical endocrinology and metabolism1 May 1982Cited by 84 (Europe PMC)

PMID7037819 (opens in a new tab)DOI10.1210/jcem-54-5-1033 (opens in a new tab)PepBankPUB-07037819
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy men, pituitary hGH significantly increased fasting plasma glucose from 96.6 to 105.9 mg/ml.

    In plain wordsIn healthy men, pituitary human growth hormone increased fasting blood glucose from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseFasting plasma glucose
    Study

    n = 12

    Comparator
    Before pituitary hGH administration
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intramuscular · four daily injectionsAs given in this study (human).

    Measurements

    Fasting glucose
    96.6 mg/ml
    before pituitary hGH; +/- 2.9
    Fasting glucose
    105.9 mg/ml
    after pituitary hGH; +/- 3.0

    Source sentences

    Summary
    Both methionyl-hGH and pituitary hGH resulted in significant carbohydrate intolerance, with a rise in fasting plasma glucose from 96.6 +/- 2.9 to 105.9 +/- 3.0 mg/ml (mean +/- SEM) after pituitary hGH
    3 context sentences
    Summary · context
    We have investigated the effects on carbohydrate metabolism of human GH produced by recombinant DNA technology (methionyl-hGH) compared with pituitary hGH.
    Summary · context
    Twelve normal adult male subjects received four daily im injections of either methionyl-hGH or pituitary hGH in a double blind, crossover study.
    Summary · context
    Oral glucose tolerance tests and assays of insulin binding to peripheral monocytes were performed before th initial administration and 12 h after the fourth injection of both hGH preparations.
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy men, pituitary hGH increased glucose tolerance curve area by 34% from baseline.

    In plain wordsIn healthy men, pituitary human growth hormone increased glucose tolerance curve area compared with baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseGlucose tolerance curve area
    Study

    n = 12

    Comparator
    Before pituitary hGH administration
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intramuscular · four daily injectionsAs given in this study (human).

    Measurements

    Glucose tolerance curve area increase
    34%
    pituitary hGH

    Source sentences

    Summary
    The area under the glucose tolerance curve increased by 34% after pituitary hGH and by 37% after methionyl-hGH.
    3 context sentences
    Summary · context
    We have investigated the effects on carbohydrate metabolism of human GH produced by recombinant DNA technology (methionyl-hGH) compared with pituitary hGH.
    Summary · context
    Twelve normal adult male subjects received four daily im injections of either methionyl-hGH or pituitary hGH in a double blind, crossover study.
    Summary · context
    Oral glucose tolerance tests and assays of insulin binding to peripheral monocytes were performed before th initial administration and 12 h after the fourth injection of both hGH preparations.
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy men, pituitary hGH increased fasting insulin from 9.4 to 33.2 microU/ml.

    In plain wordsIn healthy men, pituitary human growth hormone increased fasting insulin compared with baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseFasting plasma insulin
    Study

    n = 12

    Comparator
    Before pituitary hGH administration
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intramuscular · four daily injectionsAs given in this study (human).

    Measurements

    Fasting insulin
    9.4 microU/ml
    before pituitary hGH; +/- 1.2
    Fasting insulin
    33.2 microU/ml
    after pituitary hGH; +/- 7.8

    Source sentences

    Summary
    With both hGH preparations, carbohydrate intolerance was associated with marked hyperinsulinemia, with a rise in fasting plasma insulin levels from 9.4 +/- 1.2 to 33.2 +/- 7.8 microU/ml after pituitary hGH
    3 context sentences
    Summary · context
    We have investigated the effects on carbohydrate metabolism of human GH produced by recombinant DNA technology (methionyl-hGH) compared with pituitary hGH.
    Summary · context
    Twelve normal adult male subjects received four daily im injections of either methionyl-hGH or pituitary hGH in a double blind, crossover study.
    Summary · context
    Oral glucose tolerance tests and assays of insulin binding to peripheral monocytes were performed before th initial administration and 12 h after the fourth injection of both hGH preparations.
  4. 04HumanNon-randomized trialEfficacy outcome

    In healthy men, integrated insulin during oral glucose testing tripled after pituitary hGH.

    In plain wordsIn healthy men, pituitary human growth hormone tripled integrated insulin during glucose testing compared with baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseIntegrated plasma insulin
    Study

    n = 12

    Comparator
    Before pituitary hGH administration
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intramuscular · four daily injectionsAs given in this study (human).

    Source sentences

    Summary
    The integrated plasma insulin levels during the oral glucose tolerance test tripled after both hGH preparations.
    3 context sentences
    Summary · context
    We have investigated the effects on carbohydrate metabolism of human GH produced by recombinant DNA technology (methionyl-hGH) compared with pituitary hGH.
    Summary · context
    Twelve normal adult male subjects received four daily im injections of either methionyl-hGH or pituitary hGH in a double blind, crossover study.
    Summary · context
    Oral glucose tolerance tests and assays of insulin binding to peripheral monocytes were performed before th initial administration and 12 h after the fourth injection of both hGH preparations.
  5. 05HumanNon-randomized trialMechanism

    In healthy men, pituitary hGH produced a small, nonsignificant reduction in monocyte insulin binding at tracer concentrations.

    In plain wordsIn healthy men, pituitary human growth hormone did not significantly change monocyte insulin binding from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeMonocyte insulin binding
    Study

    n = 12

    Comparator
    Before pituitary hGH administration
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · intramuscular · four daily injectionsAs given in this study (human).

    Source sentences

    Summary
    Both hGH preparations were associated with small reductions in insulin binding to monocytes at tracer concentrations, but the decline in binding was not statistically significant.
    3 context sentences
    Summary · context
    We have investigated the effects on carbohydrate metabolism of human GH produced by recombinant DNA technology (methionyl-hGH) compared with pituitary hGH.
    Summary · context
    Twelve normal adult male subjects received four daily im injections of either methionyl-hGH or pituitary hGH in a double blind, crossover study.
    Summary · context
    Oral glucose tolerance tests and assays of insulin binding to peripheral monocytes were performed before th initial administration and 12 h after the fourth injection of both hGH preparations.
  6. 06HumanNon-randomized trialMechanism

    In healthy men, pituitary hGH did not significantly alter calculated insulin binding sites per cell.

    In plain wordsIn healthy men, pituitary human growth hormone did not significantly change insulin binding sites per cell from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeInsulin binding sites per cell
    Study

    n = 12

    Comparator
    Before pituitary hGH administration
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · intramuscular · four daily injectionsAs given in this study (human).

    Source sentences

    Summary
    The calculated binding sites per cell and Ke were not significantly altered by hGH administration.
    3 context sentences
    Summary · context
    We have investigated the effects on carbohydrate metabolism of human GH produced by recombinant DNA technology (methionyl-hGH) compared with pituitary hGH.
    Summary · context
    Twelve normal adult male subjects received four daily im injections of either methionyl-hGH or pituitary hGH in a double blind, crossover study.
    Summary · context
    Oral glucose tolerance tests and assays of insulin binding to peripheral monocytes were performed before th initial administration and 12 h after the fourth injection of both hGH preparations.
  7. 07HumanNon-randomized trialMechanism

    In healthy men, pituitary hGH did not significantly alter Ke.

    In plain wordsIn healthy men, pituitary human growth hormone did not significantly change Ke from baseline.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeKe
    Study

    n = 12

    Comparator
    Before pituitary hGH administration
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · intramuscular · four daily injectionsAs given in this study (human).

    Source sentences

    Summary
    The calculated binding sites per cell and Ke were not significantly altered by hGH administration.
    3 context sentences
    Summary · context
    We have investigated the effects on carbohydrate metabolism of human GH produced by recombinant DNA technology (methionyl-hGH) compared with pituitary hGH.
    Summary · context
    Twelve normal adult male subjects received four daily im injections of either methionyl-hGH or pituitary hGH in a double blind, crossover study.
    Summary · context
    Oral glucose tolerance tests and assays of insulin binding to peripheral monocytes were performed before th initial administration and 12 h after the fourth injection of both hGH preparations.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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