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Study · Animal study (in vivo) · mouse · 1981

3 results

Prolongation of murine skin grafts by FTS and its synthetic analogues.

Kaiserlian D, Dujic A, Dardenne M, Bach JF, Blanot D, Bricas E

Clinical and experimental immunology1 Aug 1981Cited by 7 (Europe PMC)

PMID7032771 (opens in a new tab)PepBankPUB-07032771
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with syngeneic skin grafts, CMC-bound FTS delayed rejection compared with placebo controls.

    In plain wordsIn mice with syngeneic skin grafts, FTS delayed rejection compared with placebo controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseSyngeneic skin graft survival versus placebo
    Study

    mousen: not reported in source

    Comparator
    placebo
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 ng three times weekly · until rejectionAs given in this study (mouse).

    Measurements

    Mean graft survival
    49 days
    FTS
    Reported variation
    3 days
    FTS
    Mean graft survival
    29 days
    controls with placebo
    Reported variation
    2 days
    controls with placebo

    Source sentences

    Summary
    Administration of FTS [10 ng bound to a carboxymethylcellulose (CMC) vehicle three times weekly until rejection] significantly delayed rejection (49 +/- 3 days).
    2 context sentences
    Summary · context
    In the syngeneic system, control animals with and without placebo had a mean graft survival time of 29 +/- 2 and 24 +/- 2 days respectively.
    Summary · context
    Synthetic serum thymic factor (FTS) and several of its analogues have been examined for immunoregulatory properties in a murine skin graft rejection model, including a syngeneic male-to-female system and an allogeneic system.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with syngeneic skin grafts, CMC-bound FTS delayed rejection compared with controls without placebo.

    In plain wordsIn mice with syngeneic skin grafts, FTS delayed rejection compared with controls without placebo.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseSyngeneic skin graft survival versus untreated controls
    Study

    mousen: not reported in source

    Comparator
    controls without placebo
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 ng three times weekly · until rejectionAs given in this study (mouse).

    Measurements

    Mean graft survival
    49 days
    FTS
    Reported variation
    3 days
    FTS
    Mean graft survival
    24 days
    controls without placebo
    Reported variation
    2 days
    controls without placebo

    Source sentences

    Summary
    Administration of FTS [10 ng bound to a carboxymethylcellulose (CMC) vehicle three times weekly until rejection] significantly delayed rejection (49 +/- 3 days).
    2 context sentences
    Summary · context
    In the syngeneic system, control animals with and without placebo had a mean graft survival time of 29 +/- 2 and 24 +/- 2 days respectively.
    Summary · context
    Synthetic serum thymic factor (FTS) and several of its analogues have been examined for immunoregulatory properties in a murine skin graft rejection model, including a syngeneic male-to-female system and an allogeneic system.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, FTS also delayed skin graft rejection across the H-2 barrier, with less striking effects.

    In plain wordsIn mice, FTS also delayed rejection of genetically different skin grafts, with less striking effects.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseAllogeneic skin graft rejection
    Study

    mousen: not reported in source

    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Similar although less striking results were obtained across the H-2 barrier.
    2 context sentences
    Summary · context
    Administration of FTS [10 ng bound to a carboxymethylcellulose (CMC) vehicle three times weekly until rejection] significantly delayed rejection (49 +/- 3 days).
    Summary · context
    Synthetic serum thymic factor (FTS) and several of its analogues have been examined for immunoregulatory properties in a murine skin graft rejection model, including a syngeneic male-to-female system and an allogeneic system.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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