Skip to content

Study · Randomized controlled trial · n = 16 · 1981

6 results

Calcitonin, a diabetogenic hormone?

Passariello N, Giugliano D, Sgambato S, Torella R, D'Onofrio F

The Journal of clinical endocrinology and metabolism1 Aug 1981Cited by 17 (Europe PMC)

PMID7019230 (opens in a new tab)DOI10.1210/jcem-53-2-318 (opens in a new tab)PepBankPUB-07019230
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In normal and glucose-intolerant subjects, salmon calcitonin significantly reduced insulin responses to glucose versus testing without calcitonin.

    In plain wordsIn both groups, salmon calcitonin reduced insulin responses to glucose compared with testing without calcitonin.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseInsulin response
    Study

    n = 16

    Comparator
    Oral glucose test without calcitonin
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    100 Medical Research Council UnitsAs given in this study (human).

    Source sentences

    Summary
    Plasma insulin and C-peptide responses to glucose were significantly reduced (P less than 0.01) by calcitonin at all times after the start of the test in both normal and IGT groups.
    2 context sentences
    Summary · context
    Eight subjects with normal glucose tolerance and eight with impaired glucose tolerance (IGT) were studied.
    Summary · context
    Each subject received two oral glucose tolerance tests (100 g) in random order, one under basal conditions and the other during the simultaneous in administration of salmon calcitonin (100 Medical Research Council Units).
  2. 02HumanRandomized controlled trialMechanism

    In normal and glucose-intolerant subjects, salmon calcitonin significantly reduced C-peptide responses to glucose versus testing without calcitonin.

    In plain wordsIn both groups, salmon calcitonin reduced C-peptide responses to glucose compared with testing without calcitonin.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseC-peptide response
    Study

    n = 16

    Comparator
    Oral glucose test without calcitonin
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    100 Medical Research Council UnitsAs given in this study (human).

    Source sentences

    Summary
    Plasma insulin and C-peptide responses to glucose were significantly reduced (P less than 0.01) by calcitonin at all times after the start of the test in both normal and IGT groups.
    2 context sentences
    Summary · context
    Eight subjects with normal glucose tolerance and eight with impaired glucose tolerance (IGT) were studied.
    Summary · context
    Each subject received two oral glucose tolerance tests (100 g) in random order, one under basal conditions and the other during the simultaneous in administration of salmon calcitonin (100 Medical Research Council Units).
  3. 03HumanRandomized controlled trialMechanism

    In subjects undergoing glucose testing, salmon calcitonin partially prevented glucose-mediated glucagon suppression versus testing without calcitonin.

    In plain wordsSalmon calcitonin partly prevented glucagon suppression after glucose compared with testing without calcitonin.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseGlucose-mediated glucagon suppression
    Study

    n = 16

    Comparator
    Oral glucose test without calcitonin
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    100 Medical Research Council UnitsAs given in this study (human).

    Source sentences

    Summary
    The inhibitory action of oral glucose on glucagon secretion was partially prevented by calcitonin (P less than 0.01).
    2 context sentences
    Summary · context
    Eight subjects with normal glucose tolerance and eight with impaired glucose tolerance (IGT) were studied.
    Summary · context
    Each subject received two oral glucose tolerance tests (100 g) in random order, one under basal conditions and the other during the simultaneous in administration of salmon calcitonin (100 Medical Research Council Units).
  4. 04HumanRandomized controlled trialMechanism

    In subjects undergoing glucose testing, salmon calcitonin completely blunted the terminal GH rebound versus testing without calcitonin.

    In plain wordsSalmon calcitonin blocked the GH rebound at the test's end compared with testing without calcitonin.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseGH rebound
    Study

    n = 16

    Comparator
    Oral glucose test without calcitonin
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 Medical Research Council UnitsAs given in this study (human).

    Source sentences

    Summary
    Moreover, calcitonin completely blunted the GH rebound occurring at the end of the test.
    2 context sentences
    Summary · context
    Eight subjects with normal glucose tolerance and eight with impaired glucose tolerance (IGT) were studied.
    Summary · context
    Each subject received two oral glucose tolerance tests (100 g) in random order, one under basal conditions and the other during the simultaneous in administration of salmon calcitonin (100 Medical Research Council Units).
  5. 05HumanRandomized controlled trialMechanism

    In subjects with normal glucose tolerance, salmon calcitonin increased glucose curve area versus testing without calcitonin.

    In plain wordsIn subjects with normal glucose tolerance, salmon calcitonin increased glucose curve area compared with testing without calcitonin.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseGlucose curve area in normal glucose tolerance
    Study

    n = 8

    Comparator
    Oral glucose test without calcitonin
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    100 Medical Research Council UnitsAs given in this study (human).

    Measurements

    Glucose curve area
    8208 mg/dl.min
    calcitonin
    Glucose curve area
    4400 mg/dl.min
    without calcitonin

    Source sentences

    Summary
    The integrated areas under the plasma glucose curves were 4,400 +/- 840 mg/dl.min (normals) and 8,708 +/- 1,840 mg/dl.min (IGT) without calcitonin, and 8,208 +/- 1,700 mg/dl. min (normals) and 19,500 +/- 3,500 mg/dl. min (IGT) with calcitonin (P less than 0.01).
    2 context sentences
    Summary · context
    Eight subjects with normal glucose tolerance and eight with impaired glucose tolerance (IGT) were studied.
    Summary · context
    Each subject received two oral glucose tolerance tests (100 g) in random order, one under basal conditions and the other during the simultaneous in administration of salmon calcitonin (100 Medical Research Council Units).
  6. 06HumanRandomized controlled trialMechanism

    In subjects with impaired glucose tolerance, salmon calcitonin increased glucose curve area versus testing without calcitonin.

    In plain wordsIn subjects with impaired glucose tolerance, salmon calcitonin increased glucose curve area compared with testing without calcitonin.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseGlucose curve area in impaired glucose tolerance
    Study

    n = 8

    Comparator
    Oral glucose test without calcitonin
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    100 Medical Research Council UnitsAs given in this study (human).

    Measurements

    Glucose curve area
    19,500 mg/dl.min
    calcitonin
    Glucose curve area
    8708 mg/dl.min
    without calcitonin

    Source sentences

    Summary
    The integrated areas under the plasma glucose curves were 4,400 +/- 840 mg/dl.min (normals) and 8,708 +/- 1,840 mg/dl.min (IGT) without calcitonin, and 8,208 +/- 1,700 mg/dl. min (normals) and 19,500 +/- 3,500 mg/dl. min (IGT) with calcitonin (P less than 0.01).
    2 context sentences
    Summary · context
    Eight subjects with normal glucose tolerance and eight with impaired glucose tolerance (IGT) were studied.
    Summary · context
    Each subject received two oral glucose tolerance tests (100 g) in random order, one under basal conditions and the other during the simultaneous in administration of salmon calcitonin (100 Medical Research Council Units).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.