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Study · Measured the body's own peptide · 1981

4 results

Immunocytochemical localization of thymosin-alpha 1 in thymic epithelial cells of normal and myasthenia gravis patients and in thymic cultures.

Dalakas MC, Engel WK, McClure JE, Goldstein AL, Askanas V

Journal of the neurological sciences1 May 1981Cited by 33 (Europe PMC)

PMID7014787 (opens in a new tab)DOI10.1016/0022-510x(81)90170-2 (opens in a new tab)PepBankPUB-07014787
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelEx vivo tissueOther

    In human thymus tissue, immunofluorescence located the body's own thymosin alpha‑1 only in epithelial cells.

    In plain wordsIn human thymus tissue, the body's own thymosin alpha‑1 was found only in thymic epithelial cells.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableCellular localization of thymosin alpha 1 in thymus
    Study

    humann: not reported in source

    Human thymus tissue sections
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    Alpha 1 was localized only in the epithelial cells, lying singly, grouped, in Hassall's corpuscles or proliferated in thymomas.
    1 context sentence
    Summary · context
    With antibodies against synthetic thymosin alpha 1, indirect immunofluorescence was applied to human normal thymus and to hyperplastic, thymomatous or "involuted" thymus of myasthenia gravis (MG) patients.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelEx vivo tissueOther

    In hyperplastic thymus from myasthenia gravis patients, more epithelial cells stained strongly for the body's own thymosin alpha‑1 than in normal thymus, most clearly in thymomas.

    In plain wordsIn hyperplastic myasthenia gravis thymus tissue, more cells showed strong staining for the body's own thymosin alpha‑1 than in normal thymus.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseNumber and staining strength of alpha 1-positive epithelial cells in MG hyperplastic thymus versus normal thymus
    Study

    humann: not reported in source

    Human thymus tissue sections
    Comparator
    Normal thymus
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    In contrast to normal thymus, which had fewer and more weakly stained cells, MG hyperplastic thymus had many strongly positive epithelial cells: this was markedly evident in thymomas.
    1 context sentence
    Summary · context
    With antibodies against synthetic thymosin alpha 1, indirect immunofluorescence was applied to human normal thymus and to hyperplastic, thymomatous or "involuted" thymus of myasthenia gravis (MG) patients.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelEx vivo tissueOther

    In involuted thymus from myasthenia gravis patients, a few brightly stained cells for the body's own thymosin alpha‑1 lay within fatty tissue.

    In plain wordsIn involuted myasthenia gravis thymus tissue, a few cells stained brightly for the body's own thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableAlpha 1 staining in involuted MG thymus
    Study

    humann: not reported in source

    Human thymus tissue sections
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    "Involuted" MG thymus had a few but brightly stained cells lying within the fatty tissue.
    1 context sentence
    Summary · context
    With antibodies against synthetic thymosin alpha 1, indirect immunofluorescence was applied to human normal thymus and to hyperplastic, thymomatous or "involuted" thymus of myasthenia gravis (MG) patients.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cells)Other

    In tissue cultures of human thymus, epithelial cells but not fibroblasts stained for the body's own thymosin alpha‑1.

    In plain wordsIn cultured human thymus, epithelial cells but not fibroblasts stained for the body's own thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableAlpha 1 staining in thymus tissue cultures
    Study

    humann: not reported in source

    Human thymus tissue cultures
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    In tissue cultures of human thymus, anti-alpha 1 stained the epithelial cells, but not fibroblasts.
    1 context sentence
    Summary · context
    With antibodies against synthetic thymosin alpha 1, indirect immunofluorescence was applied to human normal thymus and to hyperplastic, thymomatous or "involuted" thymus of myasthenia gravis (MG) patients.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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