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Study · Animal study (in vivo) · mouse · 1980

5 results

Nonspecific stimulation of antibacterial resistance by a synthetic thymic factor (FTS) in mice.

Matsumoto T, Nakano M

Microbiology and immunology1 Jan 1980Cited by 3 (Europe PMC)

PMID7012549 (opens in a new tab)DOI10.1111/j.1348-0421.1980.tb02923.x (opens in a new tab)PepBankPUB-07012549
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, FTS significantly increased resistance to lethal Salmonella typhimurium LT2 challenge.

    In plain wordsIn mice, FTS increased resistance to lethal Salmonella challenge.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseResistance to lethal Salmonella challenge
    Study

    mousen: not reported in source

    Salmonella typhimurium LT2 challenge
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    0.01-1 microgramAs given in this study (mouse).

    Source sentences

    Summary
    Treatment of mice with 0.01-1 microgram of a synthetic serum thymic factor (FTS) significantly increased their resistance to lethal doses (1-5 X 10(6) organisms) of Salmonella typhimurium LT2 (LT2).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, resistance required at least seven FTS injections, while effects of one to three injections varied.

    In plain wordsIn mice, at least seven FTS injections induced resistance, while one to three injections produced variable effects.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    MixedInjection frequency and resistance
    Study

    mousen: not reported in source

    Salmonella typhimurium LT2 challenge
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    0.01-1 microgramAs given in this study (mouse).

    Source sentences

    Summary
    At least seven injections of FTS were necessary for induction of resistance, since the effects of one to three injections were variable.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, FTS additively enhanced protective immunity induced by avirulent LT2 mutants.

    In plain wordsIn mice, FTS enhanced protection from immunization with avirulent LT2 mutants.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseVaccine-induced protective immunity
    Study

    mousen: not reported in source

    Salmonella typhimurium LT2 challenge
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    FTS additively potentiated the protective immunity to LT2 induced by immunization with avirulent mutant of LT2, irrespective of the structural components of the cell wall lipopolysaccharides of the mutants, which are basically correlated with their immunogenicity and virulence.
  4. 04LabEx vivo tissueActivity measurement

    In macrophages from FTS-treated DBA/2 mice, bacterial growth was retarded in vitro.

    In plain wordsIn lab tests, macrophages from FTS-treated DBA/2 mice slowed bacterial growth.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseBacterial growth inhibition by DBA/2 macrophages
    Study

    mousen: not reported in source

    peritoneal macrophages from FTS-treated DBA/2 mice
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    since peritoneal macrophages from FTS-treated DBA/2 mice which are resistant to the doses of LT2 used could by themselves retard bacterial growth in vitro
  5. 05LabEx vivo tissueMechanism

    In macrophages from FTS-treated CBA/N mice, bacterial inhibition required intervention of FTS-treated syngeneic T cells.

    In plain wordsIn lab tests, macrophages from FTS-treated CBA/N mice did not inhibit bacteria without FTS-treated matching T cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeT-cell dependence of macrophage bacterial inhibition
    Study

    mousen: not reported in source

    macrophages from FTS-treated CBA/N mice
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas those from CBA/N mice which are relatively susceptible to LT2 did not inhibit bacterial growth without intervention of FTS-treated syngeneic T cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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