In immature spleen cells from adult thymectomized mice, thymosin alpha‑1 C-terminal fragments showed in vitro activity similar to or better than the parent hormone in inducing the azathioprine-sensitive E-receptor.
In plain wordsIn lab tests, fragments of thymosin alpha‑1 worked as well as or better than the whole hormone in mouse spleen cells.
- Peptide
- Thymosin alpha-1
- Outcome
- Not applicableE-receptor expression (azathioprine E-rosette inhibition) by thymosin alpha 1 C-terminal fragments
- Study
mousen: not reported in source
Immature spleen cells from adult thymectomized mice, azathioprine E-rosette inhibition assay- Comparator
- Thymosin alpha 1
- Outcome group
- Immune response · Immune and inflammation
Source sentences
They showed immunological in vitro activities similar to and even better than the parent hormone thymosin alpha 1 in the ability to express in immature spleen cells from adult thymectomized mice the E-receptor sensitive to azathioprine inhibition.
1 context sentence(design, population, supporting numbers)
All peptides were synthesized by classical means and tested in the azathioprine E-rosette inhibition assay.
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.