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Study · Ex vivo tissue · 1981

4 results

Human postthymic precursor cells in health and disease. II. Their loss and dysfunction in systemic lupus erythematosus and their partial correction with serum thymic factor.

Palacios R, Alarcón-Segovia D, Llorente L, Ruíz-Arguelles A, Díaz-Jouanen E

Journal of clinical & laboratory immunology1 Mar 1981Cited by 19 (Europe PMC)

PMID6971333 (opens in a new tab)PepBankPUB-06971333
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    FTS pretreatment partially corrected feedback inhibition in Tar cells from two SLE patients.

    In plain wordsIn lab tests, FTS partly corrected feedback inhibition in SLE cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseFeedback inhibition
    Study

    humann = 2

    Tar cells from SLE patients
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In two SLE patients studied both of these functions corrected partially when their Tar cells were pretreated with FTS.
    2 context sentences
    Summary · context
    Characteristic functions of postthymic precursor cells are feedback inhibition and generation of suppressor cells
    Summary · context
    Herein we report that we found circulating Tar cells significantly diminished in 32 patients with untreated systemic lupus erythematosus (SLE) as compared to 32 age/sex matched controls.
  2. 02LabEx vivo tissueActivity measurement

    FTS pretreatment partially corrected suppressor-cell generation in Tar cells from two SLE patients.

    In plain wordsIn lab tests, FTS partly corrected suppressor-cell production in SLE cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseGeneration of suppressor cells
    Study

    humann = 2

    Tar cells from SLE patients
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In two SLE patients studied both of these functions corrected partially when their Tar cells were pretreated with FTS.
    2 context sentences
    Summary · context
    Characteristic functions of postthymic precursor cells are feedback inhibition and generation of suppressor cells
    Summary · context
    Herein we report that we found circulating Tar cells significantly diminished in 32 patients with untreated systemic lupus erythematosus (SLE) as compared to 32 age/sex matched controls.
  3. 03LabEx vivo tissueActivity measurement

    FTS pretreatment significantly increased Tar-cell percentages in peripheral blood mononuclear cells from SLE patients.

    In plain wordsIn lab tests, FTS pretreatment significantly increased Tar-cell percentages in SLE cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseTar-cell percentages
    Study

    humann: not reported in source

    peripheral blood mononuclear cells from SLE patients
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment of peripheral blood mononuclear cells (MNC) from SLE patients with serum from young normal adults or wtih serum thymic factors (FTS) increased their percentages of Tar cells significantly but reached near normal values in only 3 patients with inactive disease.
    1 context sentence
    Summary · context
    Herein we report that we found circulating Tar cells significantly diminished in 32 patients with untreated systemic lupus erythematosus (SLE) as compared to 32 age/sex matched controls.
  4. 04LabEx vivo tissueActivity measurement

    After pretreatment with normal serum or FTS, Tar-cell percentages reached near-normal values only in three SLE patients with inactive disease.

    In plain wordsIn lab tests, normal serum or FTS restored near-normal Tar-cell percentages only in samples from three donors with inactive SLE.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseNear-normal Tar-cell percentages
    Study

    humann: not reported in source

    peripheral blood mononuclear cells from SLE patients
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment of peripheral blood mononuclear cells (MNC) from SLE patients with serum from young normal adults or wtih serum thymic factors (FTS) increased their percentages of Tar cells significantly but reached near normal values in only 3 patients with inactive disease.
    1 context sentence
    Summary · context
    Herein we report that we found circulating Tar cells significantly diminished in 32 patients with untreated systemic lupus erythematosus (SLE) as compared to 32 age/sex matched controls.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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