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Study · Ex vivo tissue · 1980

10 results

Induction of differentiation in human marrow T cell precursors by the synthetic serum thymic factor, FTS.

Incefy GS, Mertelsmann R, Yata K, Dardenne M, Bach JF, Good RA

Clinical and experimental immunology1 May 1980Cited by 33 (Europe PMC)

PMID6969145 (opens in a new tab)PepBankPUB-06969145
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In human marrow cells from layers II or III, synthetic FTS induced HTLA surface markers.

    In plain wordsIn lab tests, synthetic FTS induced HTLA markers on selected human marrow cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseHTLA phenotype expression
    Study

    humann: not reported in source

    normal human marrow cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this study, we found that synthetic FTS induced appearance of two T cell surface markers, HTLA phenotypes and the ability to form E rosettes, on a selective population of normal human marrow cells sedimenting in layers II or III of a Ficoll discontinuous density gradient.
    1 context sentence
    Summary · context
    The serum thymic factor, 'facteur thymique serique' (FTS), was analysed in vitro for its ability to induce differentiation of normal human marrow T cell precursors into cells with T lymphocyte characteristics.
  2. 02LabEx vivo tissueActivity measurement

    In human marrow cells from layers II or III, synthetic FTS induced E-rosette formation.

    In plain wordsIn lab tests, synthetic FTS induced E-rosette formation in selected human marrow cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseE-rosette formation
    Study

    humann: not reported in source

    normal human marrow cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this study, we found that synthetic FTS induced appearance of two T cell surface markers, HTLA phenotypes and the ability to form E rosettes, on a selective population of normal human marrow cells sedimenting in layers II or III of a Ficoll discontinuous density gradient.
    1 context sentence
    Summary · context
    The serum thymic factor, 'facteur thymique serique' (FTS), was analysed in vitro for its ability to induce differentiation of normal human marrow T cell precursors into cells with T lymphocyte characteristics.
  3. 03LabEx vivo tissueActivity measurement

    In layer III human marrow cells, FTS reduced the number of lymphoid cells bearing PNA receptors.

    In plain wordsIn lab tests, FTS reduced PNA receptor-bearing lymphoid cells in human marrow layer III.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreasePNA receptor-bearing lymphoid cell number
    Study

    humann: not reported in source

    normal human marrow cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, a population of lymphoid cells also found in layer III, which bears receptors for peanut agglutinin (PNA), was decreased in number following exposure to FTS.
    1 context sentence
    Summary · context
    The serum thymic factor, 'facteur thymique serique' (FTS), was analysed in vitro for its ability to induce differentiation of normal human marrow T cell precursors into cells with T lymphocyte characteristics.
  4. 04LabEx vivo tissueActivity measurement

    In layer III human marrow cells, FTS reduced TdT activity.

    In plain wordsIn lab tests, FTS reduced TdT activity in human marrow layer III cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseTdT activity
    Study

    humann: not reported in source

    normal human marrow cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the same gradient layer, cells which expressed terminal deoxyribonucleotidyl transferase (TdT) activity showed decreased activity after treatment with FTS.
    1 context sentence
    Summary · context
    The serum thymic factor, 'facteur thymique serique' (FTS), was analysed in vitro for its ability to induce differentiation of normal human marrow T cell precursors into cells with T lymphocyte characteristics.
  5. 05LabEx vivo tissueActivity measurement

    In layer III human marrow cells, FTS enhanced responses to allogeneic peripheral blood lymphocytes.

    In plain wordsIn lab tests, FTS enhanced selected human marrow cells' responses to allogeneic blood lymphocytes.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseAllogeneic lymphocyte response
    Study

    humann: not reported in source

    normal human marrow cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Functional activities characteristic of T lymphocytes were also enhanced in marrow cells of gradient layer III after preincubation with FTS. These T cell functions were demonstrated in marrow cells by their ability to respond and to stimulate allogeneic peripheral blood lymphocytes (PBL) in mixed ly…
    1 context sentence
    Summary · context
    The serum thymic factor, 'facteur thymique serique' (FTS), was analysed in vitro for its ability to induce differentiation of normal human marrow T cell precursors into cells with T lymphocyte characteristics.
  6. 06LabEx vivo tissueActivity measurement

    In layer III human marrow cells, FTS enhanced stimulation of allogeneic peripheral blood lymphocytes.

    In plain wordsIn lab tests, FTS enhanced selected human marrow cells' stimulation of allogeneic blood lymphocytes.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseStimulation of allogeneic lymphocytes
    Study

    humann: not reported in source

    normal human marrow cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Functional activities characteristic of T lymphocytes were also enhanced in marrow cells of gradient layer III after preincubation with FTS. These T cell functions were demonstrated in marrow cells by their ability to respond and to stimulate allogeneic peripheral blood lymphocytes (PBL) in mixed ly…
    1 context sentence
    Summary · context
    The serum thymic factor, 'facteur thymique serique' (FTS), was analysed in vitro for its ability to induce differentiation of normal human marrow T cell precursors into cells with T lymphocyte characteristics.
  7. 07LabEx vivo tissueActivity measurement

    In layer III human marrow cells, FTS enhanced responses to PHA.

    In plain wordsIn lab tests, FTS enhanced PHA responses in selected human marrow cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreasePHA response
    Study

    humann: not reported in source

    normal human marrow cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Functional activities characteristic of T lymphocytes were also enhanced in marrow cells of gradient layer III after preincubation with FTS. These T cell functions were demonstrated in marrow cells by their ability to respond and to stimulate allogeneic peripheral blood lymphocytes (PBL) in mixed ly…
    1 context sentence
    Summary · context
    The serum thymic factor, 'facteur thymique serique' (FTS), was analysed in vitro for its ability to induce differentiation of normal human marrow T cell precursors into cells with T lymphocyte characteristics.
  8. 08LabEx vivo tissueActivity measurement

    In layer III human marrow cells, FTS enhanced responses to Con A.

    In plain wordsIn lab tests, FTS enhanced Con A responses in selected human marrow cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseCon A response
    Study

    humann: not reported in source

    normal human marrow cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Functional activities characteristic of T lymphocytes were also enhanced in marrow cells of gradient layer III after preincubation with FTS. These T cell functions were demonstrated in marrow cells by their ability to respond and to stimulate allogeneic peripheral blood lymphocytes (PBL) in mixed ly…
    1 context sentence
    Summary · context
    The serum thymic factor, 'facteur thymique serique' (FTS), was analysed in vitro for its ability to induce differentiation of normal human marrow T cell precursors into cells with T lymphocyte characteristics.
  9. 09LabEx vivo tissueActivity measurement

    In layer III human marrow cells, FTS enhanced responses to pokeweed.

    In plain wordsIn lab tests, FTS enhanced pokeweed responses in selected human marrow cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreasePokeweed response
    Study

    humann: not reported in source

    normal human marrow cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Functional activities characteristic of T lymphocytes were also enhanced in marrow cells of gradient layer III after preincubation with FTS. These T cell functions were demonstrated in marrow cells by their ability to respond and to stimulate allogeneic peripheral blood lymphocytes (PBL) in mixed ly…
    1 context sentence
    Summary · context
    The serum thymic factor, 'facteur thymique serique' (FTS), was analysed in vitro for its ability to induce differentiation of normal human marrow T cell precursors into cells with T lymphocyte characteristics.
  10. 10LabEx vivo tissueActivity measurement

    In human marrow layers I, IV and V, FTS did not produce the reported differentiation changes.

    In plain wordsIn lab tests, FTS did not produce these changes in human marrow layers I, IV and V.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeDifferentiation changes in other gradient layers
    Study

    humann: not reported in source

    normal human marrow cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These changes were not observed in marrow cells of gradient layers I, IV and V or after incubation with an FTS analogue that lacked biological and antigenic activity in the mouse system.
    1 context sentence
    Summary · context
    The serum thymic factor, 'facteur thymique serique' (FTS), was analysed in vitro for its ability to induce differentiation of normal human marrow T cell precursors into cells with T lymphocyte characteristics.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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