Subcellular distribution of 3 alpha-hydroxysteroid dehydrogenase and antiestrogen action on androgen-metabolizing enzymes in rat pituitary gland.

Ghraf R, Schneider K, Kirchhoff J, Hiemke C

Journal of neurochemistry1 Apr 1982Cited by 6 (Europe PMC)

PMID6950028DOI10.1111/j.1471-4159.1982.tb05324.xPepBankPUB-06950028

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In gonadectomized male rats, enclomiphene partially counteracted estradiol suppression of 5 alpha-reductase activity.
In plain wordsIn male rats without gonads, enclomiphene partly prevented estradiol from reducing 5 alpha-reductase activity.
Peptide
Enclomiphene
Outcome
IncreaseEstradiol suppression of 5 alpha-reductase
Study
ratn: not reported in source
Gonadectomized rats
Comparator
Estradiol
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
The trans-isomeric, substituted triphenylethylenes, tamoxifen, and enclomiphene, as well as nitromifene (mixture of trans and cis isomers) were able partially to counteract estradiol-induced suppression of 5 alpha-reductase, but not 3 alpha-HSDH activity.
1 context sentence(design, population, supporting numbers)
Summary · context
In the gonadectomized male rat, which was much less sensitive to intrinsic estrogenicity of the antiestrogens tested, nafoxidine completely blocked estradiol-induced suppression of 5 alpha-reductase activity and FSH release and partially antagonized suppression of LH release.
Report a problemFND-0695002805
02AnimalAnimal study (in vivo)Mechanism
In gonadectomized male rats, enclomiphene did not counteract estradiol suppression of 3 alpha-HSDH activity.
In plain wordsIn male rats without gonads, enclomiphene did not prevent estradiol from reducing 3 alpha-HSDH activity.
Peptide
Enclomiphene
Outcome
No significant changeEstradiol suppression of 3 alpha-HSDH
Study
ratn: not reported in source
Gonadectomized rats
Comparator
Estradiol
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
The trans-isomeric, substituted triphenylethylenes, tamoxifen, and enclomiphene, as well as nitromifene (mixture of trans and cis isomers) were able partially to counteract estradiol-induced suppression of 5 alpha-reductase, but not 3 alpha-HSDH activity.
1 context sentence(design, population, supporting numbers)
Summary · context
In the gonadectomized male rat, which was much less sensitive to intrinsic estrogenicity of the antiestrogens tested, nafoxidine completely blocked estradiol-induced suppression of 5 alpha-reductase activity and FSH release and partially antagonized suppression of LH release.
Report a problemFND-0695002806

Studies that did not test the peptide alone4

In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Enclomiphene.

03AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Mechanism
In ovariectomized rats, pooled nonsteroidal antiestrogens including enclomiphene had strong estrogenic effects on 3 alpha-HSDH activity.
In plain wordsIn rats without ovaries, pooled antiestrogens including enclomiphene reduced 3 alpha-HSDH activity.
Peptide
Enclomiphene
Outcome
Decrease3 alpha-HSDH activity in ovariectomized rats
Study
ratn: not reported in source
Gonadectomized rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
In the ovariectomized rat chronic administration of nonsteroidal antiestrogens had strong estrogenic effects on 3 alpha-HSDH activity and LH release, but not on 5 alpha-reductase activity and FSH release.
2 context sentences(design, population, supporting numbers)
Summary · context
Estradiol-induced suppression of NADH-linked 3 alpha-HSDH activity in pituitary homogenates from gonadectomized rats of either sex was accompanied by a similar suppression of NADPH-linked 5 alpha-reductase activity and a marked decrease of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release.
Summary · context
The trans-isomeric, substituted triphenylethylenes, tamoxifen, and enclomiphene, as well as nitromifene (mixture of trans and cis isomers) were able partially to counteract estradiol-induced suppression of 5 alpha-reductase, but not 3 alpha-HSDH activity.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0695002801
04AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Mechanism
In ovariectomized rats, pooled nonsteroidal antiestrogens including enclomiphene had strong estrogenic effects on LH release.
In plain wordsIn rats without ovaries, pooled antiestrogens including enclomiphene reduced LH release.
Peptide
Enclomiphene
Outcome
DecreaseLH release in ovariectomized rats
Study
ratn: not reported in source
Gonadectomized rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
In the ovariectomized rat chronic administration of nonsteroidal antiestrogens had strong estrogenic effects on 3 alpha-HSDH activity and LH release, but not on 5 alpha-reductase activity and FSH release.
2 context sentences(design, population, supporting numbers)
Summary · context
Estradiol-induced suppression of NADH-linked 3 alpha-HSDH activity in pituitary homogenates from gonadectomized rats of either sex was accompanied by a similar suppression of NADPH-linked 5 alpha-reductase activity and a marked decrease of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release.
Summary · context
The trans-isomeric, substituted triphenylethylenes, tamoxifen, and enclomiphene, as well as nitromifene (mixture of trans and cis isomers) were able partially to counteract estradiol-induced suppression of 5 alpha-reductase, but not 3 alpha-HSDH activity.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0695002802
05AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Mechanism
In ovariectomized rats, pooled nonsteroidal antiestrogens lacked strong estrogenic effects on 5 alpha-reductase activity.
In plain wordsIn rats without ovaries, pooled antiestrogens including enclomiphene did not show strong estrogen-like effects on 5 alpha-reductase activity.
Peptide
Enclomiphene
Outcome
Direction not reported5 alpha-reductase activity in ovariectomized rats
Study
ratn: not reported in source
Gonadectomized rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
In the ovariectomized rat chronic administration of nonsteroidal antiestrogens had strong estrogenic effects on 3 alpha-HSDH activity and LH release, but not on 5 alpha-reductase activity and FSH release.
1 context sentence(design, population, supporting numbers)
Summary · context
The trans-isomeric, substituted triphenylethylenes, tamoxifen, and enclomiphene, as well as nitromifene (mixture of trans and cis isomers) were able partially to counteract estradiol-induced suppression of 5 alpha-reductase, but not 3 alpha-HSDH activity.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0695002803
06AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Mechanism
In ovariectomized rats, pooled nonsteroidal antiestrogens lacked strong estrogenic effects on FSH release.
In plain wordsIn rats without ovaries, pooled antiestrogens including enclomiphene did not show strong estrogen-like effects on FSH release.
Peptide
Enclomiphene
Outcome
Direction not reportedFSH release in ovariectomized rats
Study
ratn: not reported in source
Gonadectomized rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
In the ovariectomized rat chronic administration of nonsteroidal antiestrogens had strong estrogenic effects on 3 alpha-HSDH activity and LH release, but not on 5 alpha-reductase activity and FSH release.
1 context sentence(design, population, supporting numbers)
Summary · context
The trans-isomeric, substituted triphenylethylenes, tamoxifen, and enclomiphene, as well as nitromifene (mixture of trans and cis isomers) were able partially to counteract estradiol-induced suppression of 5 alpha-reductase, but not 3 alpha-HSDH activity.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0695002804

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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