Studies on the location and release of cholecystokinin and vasoactive intestinal peptide in rat and cat spinal cord.

Yaksh TL, Abay EO 2nd, Go VL

Brain research1 Jun 1982Cited by 116 (Europe PMC)

PMID6896838DOI10.1016/0006-8993(82)90311-0PepBankPUB-06896838

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Natural levels measured11

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In cats, natural VIP was found in the lumbar spinal ganglion and spinal cord, with higher levels in dorsal than in ventral horn.
In plain wordsIn cats, the body's own VIP was present in the lower spinal cord and ganglion, with higher levels at the back.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableVIP levels in cat lumbar spinal ganglion and spinal cord
Study
catn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
By radioimmunoassay vasoactive intestinal peptide (VIP) and cholecystokinin (CCK) are found in the cat lumbar spinal ganglion and spinal cord with levels in dorsal greater than ventral horn.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0689683801
02AnimalEndogenous levelAnimal study (in vivo)Other
Unilateral rhizotomy, but not cervical hemisection, produced a significant but incomplete depletion of VIP immunoreactivity in dorsal horn, not in ventral horn.
In plain wordsCutting the dorsal nerve roots, but not the upper spinal cord, partly lowered the body's own VIP in the back part of the spinal cord.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseVIP immunoreactivity after rhizotomy or cervical hemisection
Study
n: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Unilateral rhizotomy, but not cervical hemisection produced a significant but incomplete depletion of CCK and VIP immunoreactivity in dorsal, but not ventral horn.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0689683802
03AnimalEndogenous levelAnimal study (in vivo)Other
Intrathecal capsaicin had no effect on the levels of spinal VIP.
In plain wordsCapsaicin given into the spinal canal did not change the body's own VIP levels in the spinal cord.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeSpinal VIP after intrathecal capsaicin
Study
n: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Intrathecal capsaicin (0.5 mg) had no effect on the levels of spinal VIP or CCK.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0689683803
04AnimalEndogenous levelAnimal study (in vivo)Other
Intrathecal colchicine significantly increased VIP levels in the dorsal and ventral horn.
In plain wordsColchicine given into the spinal canal raised the body's own VIP levels in both the back and front parts of the spinal cord.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseSpinal VIP after intrathecal colchicine
Study
n: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Intrathecal colchicine (0.5 mg)produced a significant increase in the levels of VIP in the dorsal and ventral horn but had no effect on the levels of CCK.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0689683804
05AnimalEndogenous levelAnimal study (in vivo)Other
In anaesthetized cats and rats, in situ superfusion of the spinal cord showed measurable levels of VIP.
In plain wordsIn cats and rats, the body's own VIP could be measured in fluid washed over the spinal cord.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableMeasurable VIP in spinal cord superfusate
Study
cat, ratn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
The present experiments, using a preparation which permits in situ superfusion of the spinal cord, demonstrated in the chloralose-urethanized cat and rat the presence of measurable levels of VIP and CCK.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0689683805
06AnimalEndogenous levelAnimal study (in vivo)Other
In rats, excess potassium increased VIP in spinal superfusate by 46% above resting levels.
In plain wordsIn rats, extra potassium raised the body's own VIP released from the spinal cord by 46% above resting levels.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePotassium-evoked VIP release from rat spinal cord
Study
ratn: not reported in source
Comparator
Resting level
Outcome group
Endogenous peptide levels · Nervous system and cognition
Measurements
VIP increase
46%
rat spinal superfusate, 40 mM potassium
Source sentences
Summary
In rats, the addition of potassium (40 mM in excess) resulted in a 138% and 46% increase in the levels of CCK and VIP, respectively above resting levels (3.7 +/- 1.2 fmol/ml/10 min and 1.7 +/- 0.5 fmol/ml/10 min, respectively).
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0689683806
07AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, removing calcium and adding cobalt significantly reduced the potassium-evoked release of the spinal peptides, which included VIP.
In plain wordsIn rats, removing calcium and adding cobalt reduced the potassium-driven release of spinal peptides, which included the body's own VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseEffect of calcium deletion and cobalt on potassium-evoked release
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
In rats, the addition of potassium (40 mM in excess) resulted in a 138% and 46% increase in the levels of CCK and VIP, respectively above resting levels (3.7 +/- 1.2 fmol/ml/10 min and 1.7 +/- 0.5 fmol/ml/10 min, respectively). The deletion of calcium and substitution of cobalt (2 mM) resulted in a…
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0689683807
08AnimalEndogenous levelAnimal study (in vivo)Other
Intrathecal picrotoxin had no effect on VIP levels in the spinal superfusates.
In plain wordsPicrotoxin given into the spinal canal did not change the body's own VIP in fluid washed over the spinal cord.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeSpinal VIP after intrathecal picrotoxin
Study
n: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Intrathecal picrotoxin doubled the levels of CCK, but had no effect on the levels of VIP in the spinal superfusates.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0689683808
09AnimalEndogenous levelAnimal study (in vivo)Other
In rats, capsaicin had no effect on VIP levels in spinal superfusate.
In plain wordsIn rats, capsaicin did not change the body's own VIP in fluid washed over the spinal cord.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeRat spinal VIP after capsaicin superfusion
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Capsaicin (3 X 10(-4) M) had no effect on the levels of either peptide in rat spinal superfusate.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0689683809
10AnimalEndogenous levelAnimal study (in vivo)Other
In cats, high-intensity but not low-intensity sciatic nerve stimulation increased spinal VIP by 132% above baseline.
In plain wordsIn cats, strong but not weak electrical stimulation of the sciatic nerve raised the body's own VIP in the spinal cord by 132%.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseVIP release after sciatic nerve stimulation
Study
catn: not reported in source
Comparator
Prestimulation baseline
Outcome group
Endogenous peptide levels · Nervous system and cognition
Measurements
VIP increase
132%
cat, high-intensity sciatic stimulation
Source sentences
Summary
In cats, bilateral electrical stimulation of the sciatic nerve at high, but not low intensity, resulted in a 218% and 132% increase above prestimulation baseline in the levels of CCK and VIP, respectively.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0689683810
11AnimalEndogenous levelAnimal study (in vivo)Mechanism
Column separation showed that all VIP-like activity in spinal cord tissue and superfusate travelled in a single peak that co-migrated with authentic VIP.
In plain wordsLab separation showed that the body's own VIP-like material in spinal cord tissue and fluid matched real VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableChemical identity of spinal VIP immunoreactivity
Study
n: not reported in source
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Column separation of spinal cord and the superfusate obtained during basal and evoked release, revealed that all activity in both the tissue and perfusate samples, travelled in a single peak which co-migrated with authentic VIP.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0689683811

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

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