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Study · Animal study (in vivo) · rat · 1981

4 results

DSIP-like immunoreactivity in the developing rat brain.

Kastin AJ, Nissen C, Coy DH

Brain research bulletin1 Dec 1981Cited by 6 (Europe PMC)

PMID6895711 (opens in a new tab)DOI10.1016/0361-9230(81)90119-2 (opens in a new tab)PepBankPUB-06895711
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats injected with DSIP 2 months earlier, brain DSIP-like immunoreactivity showed no marked difference in levels.

    In plain wordsIn rats, brain DSIP-like levels showed no marked difference two months after DSIP injection.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeBrain DSIP-like immunoreactivity 2 months after DSIP injection
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · 2 months follow-upAs given in this study (rat).

    Source sentences

    Summary
    No marked differences in the levels of DSIP-like immunoreactivity were found in the brains of rats injected 2 months earlier with DSIP
    1 context sentence
    Summary · context
    The concentration of DSIP-like material was measured by a highly specific radioimmunoassay in brain tissue from developing rats.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In developing rats, the body's own DSIP-like immunoreactivity in fetal brain was present at increased levels shortly before birth.

    In plain wordsIn rats, the body's own DSIP-like material in the brain rose shortly before birth.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDSIP-like immunoreactivity in fetal rat brain
    Study

    ratn: not reported in source

    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    DSIP-like immunoreactivity was present in fetal brain at increased levels shortly before birth.
    1 context sentence
    Summary · context
    The concentration of DSIP-like material was measured by a highly specific radioimmunoassay in brain tissue from developing rats.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  2. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In developing rats, the body's own DSIP-like immunoreactivity was significantly raised at postnatal day 20 in one experiment, and later in a second similar study.

    In plain wordsIn rats, natural DSIP-like levels in the brain rose at about three weeks of age in one experiment and later in another.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDSIP-like immunoreactivity at postnatal day 20
    Study

    ratn: not reported in source

    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Measurements

    Postnatal day of elevation
    20 days
    first experiment

    Source sentences

    Summary
    In one experiment, a significant elevation in the concentration of the peptide occurred at postnatal day 20, but in a second, similar, study the increase occurred later.
    1 context sentence
    Summary · context
    The concentration of DSIP-like material was measured by a highly specific radioimmunoassay in brain tissue from developing rats.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  3. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In developing rats, the body's own DSIP-like immunoreactivity showed no marked differences among 10 parts of the brain at postnatal day 20.

    In plain wordsIn rats, natural DSIP-like levels did not differ markedly among 10 brain parts at about three weeks of age.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeDSIP-like immunoreactivity across 10 brain parts at postnatal day 20
    Study

    ratn: not reported in source

    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    or among 10 parts of brains obtained at postnatal day 20.
    1 context sentence
    Summary · context
    The concentration of DSIP-like material was measured by a highly specific radioimmunoassay in brain tissue from developing rats.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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