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Study · In vitro (cell-free) · rat · 1983

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Observations on N alpha-deacetylation of model amino acids and peptides: distribution and purification of a specific N-acyl amino acid releasing enzyme in rat brain.

Marks N, Lo ES, Stern F, Danho W

Journal of neurochemistry1 Jul 1983Cited by 18 (Europe PMC)

PMID6864220 (opens in a new tab)DOI10.1111/j.1471-4159.1983.tb13670.x (opens in a new tab)PepBankPUB-06864220
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Activity measurement

    In a cell-free assay, purified rat brain NAARE did not hydrolyze N-terminally acetylated thymosin alpha‑1.

    In plain wordsIn lab tests with a purified rat brain enzyme, thymosin alpha‑1 was not broken down.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeHydrolysis by N-acyl amino acid releasing enzyme
    Study

    ratn: not reported in source

    purified rat brain N-acyl amino acid releasing enzyme (NAARE)
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No hydrolysis was observed for polypeptides with five or more residues having N-terminal acetylated Tyr (enkephalin) or Ser (alpha-melanocyte-stimulating hormone, thymosin alpha 1), supporting the notion that the enzyme plays a role only in turnover of smaller peptides formed perhaps as a result of…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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