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Study · Measured the body's own peptide · 1983

3 results

Circadian rhythm of thymosin-alpha 1 in normal and thymectomized mice.

McGillis JP, Hall NR, Goldstein AL

Journal of immunology (Baltimore, Md. : 1950)1 Jul 1983Cited by 27 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In mice, serum thymosin alpha‑1 showed a circadian rhythm, peaking 1.5 hr after light onset.

    In plain wordsIn mice, the body's own thymosin alpha‑1 level in blood rose and fell over the day, peaking soon after light onset.

    Outcome
    Not applicableCircadian rhythm of serum thymosin alpha 1
    Study

    mousen: not reported in source

    C57BL/6 or Swiss Webster mice
    Outcome group
    Immune response · Immune and inflammation

    Measurements

    amplitude
    0.493 ng/ml
    Tsn-alpha 1-like immunoreactivity
    acrophase
    1.5 hr after light onset
    peak time

    Source sentences

    Summary
    Results from the first experiment showed that Tsn-alpha 1 undergoes a circadian rhythm (p less than 0.001) with an acrophase (time of peak levels) 1.5 hr after the onset of light, and an amplitude (amount of maximum variation from the 24-hr mean) of 0.493 ng/ml Tsn-alpha 1-like immunoreactivity.
    2 context sentences
    Summary · context
    In these experiments, groups of 10 C57BL/6 or Swiss Webster mice were sacrificed at 4- or 6-hr intervals over a 24-hr period.
    Summary · context
    Serum Tsn-alpha 1 and corticosterone levels were determined by radioimmunoassay.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In mice kept on a reversed light cycle, the circadian rhythm of serum thymosin alpha‑1 was confirmed.

    In plain wordsIn mice on a reversed light cycle, the body's own thymosin alpha‑1 still followed a daily rhythm.

    Outcome
    Not applicableCircadian rhythm of thymosin alpha 1 under a reversed light cycle
    Study

    mousen: not reported in source

    C57BL/6 or Swiss Webster mice
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    These results were confirmed in an experiment in which the animals were placed on a reversed light cycle.
    3 context sentences
    Summary · context
    Results from the first experiment showed that Tsn-alpha 1 undergoes a circadian rhythm (p less than 0.001) with an acrophase (time of peak levels) 1.5 hr after the onset of light, and an amplitude (amount of maximum variation from the 24-hr mean) of 0.493 ng/ml Tsn-alpha 1-like immunoreactivity.
    Summary · context
    In these experiments, groups of 10 C57BL/6 or Swiss Webster mice were sacrificed at 4- or 6-hr intervals over a 24-hr period.
    Summary · context
    Serum Tsn-alpha 1 and corticosterone levels were determined by radioimmunoassay.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In mice thymectomized 6 months earlier, the circadian rhythm of serum thymosin alpha‑1 persisted.

    In plain wordsIn mice with the thymus removed, the body's own thymosin alpha‑1 still followed a daily rhythm.

    Outcome
    Not applicableCircadian rhythm of thymosin alpha 1 in thymectomized mice
    Study

    mousen: not reported in source

    C57BL/6 or Swiss Webster mice
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    In a separate experiment, the Tsn-alpha 1 circadian rhythm persisted in mice thymectomized 6 mo. earlier.
    3 context sentences
    Summary · context
    Results from the first experiment showed that Tsn-alpha 1 undergoes a circadian rhythm (p less than 0.001) with an acrophase (time of peak levels) 1.5 hr after the onset of light, and an amplitude (amount of maximum variation from the 24-hr mean) of 0.493 ng/ml Tsn-alpha 1-like immunoreactivity.
    Summary · context
    In these experiments, groups of 10 C57BL/6 or Swiss Webster mice were sacrificed at 4- or 6-hr intervals over a 24-hr period.
    Summary · context
    Serum Tsn-alpha 1 and corticosterone levels were determined by radioimmunoassay.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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