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Study · Animal study (in vivo) · rabbit · 1983

4 results

Synthesis of delta sleep-inducing peptide (DSIP) and its physiological activity.

Ji AX, Li CX, Ye YH, Lin Y, Xing QY, Liu SY, Zhang WY, Wang ZS, Dai XJ

Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences1 Feb 1983Cited by 1 (Europe PMC)

PMID6857232 (opens in a new tab)PepBankPUB-06857232
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, synthetic DSIP intensified delta and sigma waves on the EEG.

    In plain wordsIn rabbits, synthetic DSIP increased delta and sigma brain waves on the EEG.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDelta and sigma waves on EEG
    Study

    rabbitn: not reported in source

    EEG recording
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated · intravenous or mesodiencephalic ventricular infusionAs given in this study (rabbit).

    Source sentences

    Summary
    Its function of intensifying delta and sigma waves on rabbit's electroencephalogram (EEG) is evident.
    1 context sentence
    Summary · context
    The physiological activities of synthetic DSIP are performed on rabbits by using intravenous administration or mesodiencephalic ventricular infusion.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, mesodiencephalic infusion of 10 or 20 times higher than 5 microgram/rabbit doses gave no concomitant increase in the delta- and sigma-enhancing effect.

    In plain wordsIn rabbits, much higher doses infused into the brain did not add to the brain-wave effect.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeDelta and sigma waves at 10 or 20 times higher ventricular dose
    Study

    rabbitn: not reported in source

    EEG recording
    Outcome group
    Sleep · Sleep
    Studied dose
    10 or 20 times higher than 5 microgram/rabbit · mesodiencephalic ventricular infusionAs given in this study (rabbit).

    Source sentences

    Summary
    There is no concomitant increase of delta- and sigma-enhancing effect following mesodiencephalic ventricular infusion of 10 or 20 times higher than 5 microgram/rabbit doses.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, 6-day consecutive intravenous DSIP at 50 microgram/kg showed no obvious sign of adaptation.

    In plain wordsIn rabbits, six days of daily DSIP injections showed no obvious loss of effect.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeAdaptation to repeated intravenous DSIP
    Study

    rabbitn: not reported in source

    EEG recording
    Outcome group
    Sleep · Sleep
    Studied dose
    50 microgram/kg · intravenous · 6 consecutive daysAs given in this study (rabbit).

    Source sentences

    Summary
    Results of 6-day consecutive intravenous administration (50 microgram/kg) indicate that there is no obvious sign of adaptation to DSIP.

Studies that did not test the peptide alone1

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 04LabNot a test of Delta sleep-inducing peptide (DSIP) aloneIn vitro (cell-free)Other

    DSIP was synthesized by a classical method and purified, and alpha to beta transposition of the Asp residue was found to be absent.

    In plain wordsIn lab work, DSIP was made and purified without the aspartate rearrangement.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableSynthesis and purity of DSIP
    Study

    n: not reported in source

    Chemical synthesis and purification
    Outcome group
    Analytical methods and detection · Pharmacology

    Source sentences

    Summary
    Protected nonapeptide--Delta Sleep-Inducing Peptide (DSIP) formula: see text has been synthesized by classical method.
    1 context sentence
    Summary · context
    The product has been treated with TFA and purified on DEAE-Sephadex-A25 column, pure free nonapeptide obtained and alpha to beta transposition of Asp-residue found to be absent.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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