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Study · Randomized controlled trial · n = 11 · 1983

1 result

Prolactin-releasing activity of dermorphin, a new synthetic potent opiate-like peptide, in normal human subjects.

Degli Uberti EC, Trasforini G, Salvadori S, Tomatis R, Margutti A, Bianconi M, Rotola C, Pansini R

The Journal of clinical endocrinology and metabolism1 May 1983Cited by 22 (Europe PMC)

PMID6833466 (opens in a new tab)DOI10.1210/jcem-56-5-1032 (opens in a new tab)PepBankPUB-06833466
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In volunteers, dermorphin significantly increased prolactin levels, more consistently in women than men.

    In plain wordsIn volunteers, dermorphin increased prolactin compared with saline placebo, more consistently in women than men.

    Peptide
    Dermorphin
    Outcome
    IncreaseProlactin levels
    Study

    n = 11

    Comparator
    0.9% saline placebo
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    5.5 micrograms/kg . min · intravenous · 30 minAs given in this study (human).

    Source sentences

    Summary
    In all the subjects, D induced a significant increase in the levels of PRL, more consistently in women than in men.
    1 context sentence
    Summary · context
    To study the effect of a synthetic D on PRL secretion in man, either D (5.5 micrograms/kg . min for 30 min) or D-placebo (0.9% saline) infusion over 30 min was administered iv in random sequence to 11 volunteers (6 women and 5 men).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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