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Study · Not a test of the peptide alone · 1981

4 results

[Role of zinc and other metals in the biological activity of the serum thymic factor (thymulin)].

Dardenne M, Pleau JM, Lefrancier P, Bach JF

Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie1 Mar 1981Cited by 5 (Europe PMC)

PMID6791843 (opens in a new tab)PepBankPUB-06791843
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 01LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cell-free)Activity measurement

    Synthetic or natural FTS lost biological activity after passage through Chelex 100.

    In plain wordsIn lab tests, FTS lost biological activity after passage through a metal-binding agent.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseBiological activity after chelation
    Study

    n: not reported in source

    synthetic or natural FTS
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The serum thymic factor (FTS) used in synthetic or natural form, loses its biological activity after passage on a chelating agent, Chelex 100.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 02LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cell-free)Activity measurement

    Adding zinc restored the biological activity of chelated FTS.

    In plain wordsIn lab tests, zinc restored FTS activity after metal removal.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseBiological activity after zinc addition
    Study

    n: not reported in source

    synthetic or natural FTS
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Such activity is recovered after addition of zinc and, to a lesser degree, of certain other metals.
    1 context sentence
    Summary · context
    The serum thymic factor (FTS) used in synthetic or natural form, loses its biological activity after passage on a chelating agent, Chelex 100.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 03LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cell-free)Activity measurement

    Certain other metals restored chelated FTS activity to a lesser degree than zinc.

    In plain wordsIn lab tests, certain other metals restored FTS activity less than zinc did.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseBiological activity after other metals
    Study

    n: not reported in source

    synthetic or natural FTS
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Such activity is recovered after addition of zinc and, to a lesser degree, of certain other metals.
    1 context sentence
    Summary · context
    The serum thymic factor (FTS) used in synthetic or natural form, loses its biological activity after passage on a chelating agent, Chelex 100.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  4. 04LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cell-free)Mechanism

    FTS activation resulted from zinc binding to the peptide.

    In plain wordsIn lab tests, zinc binding activated FTS.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableZinc binding and activation
    Study

    n: not reported in source

    synthetic or natural FTS
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    FTS activation is secondary to zinc binding to the peptide.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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