Skip to content

Study · Non-randomized trial · n = 13 · 1980

5 results

Effects of calcitonin on basal and thyrotropin-releasing hormone-stimulated prolactin secretion in man.

Isaac R, Merceron R, Caillens G, Raymond JP, Ardaillou R

The Journal of clinical endocrinology and metabolism1 Jun 1980Cited by 31 (Europe PMC)

PMID6768762 (opens in a new tab)DOI10.1210/jcem-50-6-1011 (opens in a new tab)PepBankPUB-06768762
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialMechanism

    In healthy subjects and patients with hyperprolactinemia, salmon calcitonin reduced plasma prolactin, with maximum falls after 30--60 min.

    In plain wordsSalmon calcitonin reduced prolactin in healthy subjects and patients with high prolactin, with maximum falls after 30--60 min.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseBasal prolactin
    Study

    n = 13

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    Plasma PRL fell in nine healthy subjects and four patients with hyperprolactinemia after iv administration of salmon calcitonin (CT).
    1 context sentence
    Summary · context
    The maximum fall was observed 30--60 min after the infusion.
  2. 02HumanNon-randomized trialMechanism

    In healthy subjects, prolactin before TRH was lower with prior salmon calcitonin than without calcitonin.

    In plain wordsIn healthy subjects, prolactin before TRH was lower after salmon calcitonin than without calcitonin.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseProlactin before TRH
    Study

    n = 5

    Comparator
    Same protocol without calcitonin
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    Plasma PRL before TRH injection was clearly lower when CT had been administered.
    2 context sentences
    Summary · context
    In five healthy subjects, TRH was injected 60 min after the CT infusion. This protocol was repeated in the same subjects at 3-day intervals, except CT was not administered.
    Summary · context
    Plasma PRL fell in nine healthy subjects and four patients with hyperprolactinemia after iv administration of salmon calcitonin (CT).
  3. 03HumanNon-randomized trialMechanism

    In healthy subjects, prior salmon calcitonin inhibited the prolactin response to TRH versus testing without calcitonin.

    In plain wordsIn healthy subjects, salmon calcitonin reduced the prolactin response to TRH compared with testing without calcitonin.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseProlactin response to TRH
    Study

    n = 5

    Comparator
    Same protocol without calcitonin
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    PRL and TSH responses to TRH were markedly inhibited when CT had been previously infused.
    2 context sentences
    Summary · context
    In five healthy subjects, TRH was injected 60 min after the CT infusion. This protocol was repeated in the same subjects at 3-day intervals, except CT was not administered.
    Summary · context
    Plasma PRL fell in nine healthy subjects and four patients with hyperprolactinemia after iv administration of salmon calcitonin (CT).
  4. 04HumanNon-randomized trialMechanism

    In healthy subjects, prior salmon calcitonin inhibited the TSH response to TRH versus testing without calcitonin.

    In plain wordsIn healthy subjects, salmon calcitonin reduced the TSH response to TRH compared with testing without calcitonin.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseTSH response to TRH
    Study

    n = 5

    Comparator
    Same protocol without calcitonin
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    PRL and TSH responses to TRH were markedly inhibited when CT had been previously infused.
    2 context sentences
    Summary · context
    In five healthy subjects, TRH was injected 60 min after the CT infusion. This protocol was repeated in the same subjects at 3-day intervals, except CT was not administered.
    Summary · context
    Plasma PRL fell in nine healthy subjects and four patients with hyperprolactinemia after iv administration of salmon calcitonin (CT).
  5. 05HumanNon-randomized trialMechanism

    In the studied subjects, salmon calcitonin did not change plasma GH, FSH, LH, or TSH.

    In plain wordsIn the studied subjects, salmon calcitonin did not change blood GH, FSH, LH, or TSH.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changeOther anterior pituitary hormones
    Study

    n: not reported in source

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    There was no change in the plasma concentrations of the other anterior pituitary hormones tested (GH, FSH, LH, and TSH).
    1 context sentence
    Summary · context
    Plasma PRL fell in nine healthy subjects and four patients with hyperprolactinemia after iv administration of salmon calcitonin (CT).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.