Comparison of vasoactive intestinal peptide and isoproterenol relaxant effects in isolated cat airways.

Altiere RJ, Diamond L

Journal of applied physiology: respiratory, environmental and exercise physiology1 Apr 1984Cited by 22 (Europe PMC)

PMID6725078DOI10.1152/jappl.1984.56.4.986PepBankPUB-06725078

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
VIP and isoproterenol were nearly equipotent in relaxing extrapulmonary cat airways.
In plain wordsIn lab tests on cat airways, VIP and isoproterenol relaxed the larger airways with nearly the same potency.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeRelaxation of extrapulmonary airways, VIP versus isoproterenol
Study
catn: not reported in source
isolated precontracted cat trachea and bronchi
Comparator
Isoproterenol
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
VIP and isoproterenol were nearly equipotent in causing relaxation of extrapulmonary airways.
1 context sentence(design, population, supporting numbers)
Summary · context
In precontracted segments of cat trachea, hilar bronchus, and intrapulmonary bronchus, concentration-relaxation curves to VIP were compared with those produced by isoproterenol.
Report a problemFND-0672507801
02LabEx vivo tissueEfficacy outcome
Sensitivity to VIP relaxation decreased in progressively smaller cat airways.
In plain wordsIn lab tests on cat airways, smaller airways were less sensitive to VIP relaxation.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseRegional sensitivity of airways to VIP
Study
catn: not reported in source
isolated precontracted cat trachea and bronchi
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
A decreasing sensitivity to VIP was observed in progressively smaller airways, suggesting regional variation in VIP-induced responses.
1 context sentence(design, population, supporting numbers)
Summary · context
In precontracted segments of cat trachea, hilar bronchus, and intrapulmonary bronchus, concentration-relaxation curves to VIP were compared with those produced by isoproterenol.
Report a problemFND-0672507802
03LabEx vivo tissueMechanism
Propranolol had no effect on VIP concentration-response curves in cat airways, although it antagonized isoproterenol.
In plain wordsIn lab tests on cat airways, propranolol did not change VIP relaxation.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeEffect of propranolol on VIP relaxation
Study
catn: not reported in source
isolated precontracted cat trachea and bronchi
Comparator
Propranolol
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
Propranolol (10(-6) M), which antagonized relaxation responses to isoproterenol, had no effect on VIP concentration-response curves.
1 context sentence(design, population, supporting numbers)
Summary · context
In precontracted segments of cat trachea, hilar bronchus, and intrapulmonary bronchus, concentration-relaxation curves to VIP were compared with those produced by isoproterenol.
Report a problemFND-0672507803
04LabEx vivo tissueMechanism
Indomethacin did not inhibit VIP-induced relaxation of cat airways.
In plain wordsIn lab tests on cat airways, indomethacin did not block VIP relaxation.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeEffect of indomethacin on VIP relaxation
Study
catn: not reported in source
isolated precontracted cat trachea and bronchi
Comparator
Indomethacin
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
Indomethacin (10(-5) M) completely prevented responses to exogenous arachidonic acid but did not inhibit VIP-induced relaxation.
1 context sentence(design, population, supporting numbers)
Summary · context
In precontracted segments of cat trachea, hilar bronchus, and intrapulmonary bronchus, concentration-relaxation curves to VIP were compared with those produced by isoproterenol.
Report a problemFND-0672507804
05LabEx vivo tissueMechanism
Avian pancreatic polypeptide was unable to antagonize VIP-induced airway smooth muscle relaxation in cat airways.
In plain wordsIn lab tests on cat airways, avian pancreatic polypeptide did not block VIP relaxation.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeEffect of avian pancreatic polypeptide on VIP relaxation
Study
catn: not reported in source
isolated precontracted cat trachea and bronchi
Comparator
Avian pancreatic polypeptide
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
Avian pancreatic polypeptide, which has been reported to inhibit vasodilator responses to VIP in the cat, was unable to antagonize airway smooth muscle relaxation induced by VIP.
1 context sentence(design, population, supporting numbers)
Summary · context
In precontracted segments of cat trachea, hilar bronchus, and intrapulmonary bronchus, concentration-relaxation curves to VIP were compared with those produced by isoproterenol.
Report a problemFND-0672507805
06LabEx vivo tissueEfficacy outcome
VIP relaxed precontracted segments of isolated cat trachea, hilar bronchus and intrapulmonary bronchus.
In plain wordsIn lab tests on cat airways, VIP relaxed airway muscle that had been tightened beforehand.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation of precontracted cat trachea and bronchi by VIP
Study
catn: not reported in source
isolated precontracted cat trachea and bronchi
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
These results demonstrate that VIP is a potent relaxant of cat tracheobronchial smooth muscle in vitro
Report a problemFND-0672507806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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