Increases in heart rate and blood pressure produced by injections of dermorphin into discrete hypothalamic sites.

Diz DI, Vitale JA, Jacobowitz DM

Brain research1 Feb 1984Cited by 18 (Europe PMC)

PMID6697241DOI10.1016/0006-8993(84)91308-8PepBankPUB-06697241

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In anesthetized rats, dermorphin in the caudal anterior hypothalamic nucleus increased blood pressure by 8%, unlike vehicle.
In plain wordsIn rats, dermorphin in the caudal anterior hypothalamus increased blood pressure by 8%, unlike vehicle.
Peptide
Dermorphin
Outcome
IncreaseBlood pressure in caudal anterior hypothalamic nucleus
Study
ratn: not reported in source
halothane-anesthetized rats
Comparator
vehicle
Outcome group
Blood pressure · Cardiovascular
Studied dose
40 pmol · intrahypothalamic injectionAs given in this study (rat).
Measurements
Blood pressure increase
8%
caudal anterior hypothalamic nucleus
Source sentences
Summary
In the caudal anterior hypothalamic nucleus (A5800-5300), dermorphin, but not vehicle, increased blood pressure 8% and heart rate 26%, without changing respiration rate.
1 context sentence(design, population, supporting numbers)
Summary · context
Central cardiovascular sites of action for dermorphin were determined by injecting 40 pmol of the peptide into discrete sites within the hypothalamus of halothane anesthetized rats.
Report a problemFND-0669724101
02AnimalAnimal study (in vivo)Activity measurement
In anesthetized rats, dermorphin in the caudal anterior hypothalamic nucleus increased heart rate by 26%, unlike vehicle.
In plain wordsIn rats, dermorphin in the caudal anterior hypothalamus increased heart rate by 26%, unlike vehicle.
Peptide
Dermorphin
Outcome
IncreaseHeart rate in caudal anterior hypothalamic nucleus
Study
ratn: not reported in source
halothane-anesthetized rats
Comparator
vehicle
Outcome group
Heart function · Cardiovascular
Studied dose
40 pmol · intrahypothalamic injectionAs given in this study (rat).
Measurements
Heart rate increase
26%
caudal anterior hypothalamic nucleus
Source sentences
Summary
In the caudal anterior hypothalamic nucleus (A5800-5300), dermorphin, but not vehicle, increased blood pressure 8% and heart rate 26%, without changing respiration rate.
1 context sentence(design, population, supporting numbers)
Summary · context
Central cardiovascular sites of action for dermorphin were determined by injecting 40 pmol of the peptide into discrete sites within the hypothalamus of halothane anesthetized rats.
Report a problemFND-0669724102
03AnimalAnimal study (in vivo)Activity measurement
In anesthetized rats, dermorphin in the caudal anterior hypothalamic nucleus did not change respiration rate.
In plain wordsIn rats, dermorphin in the caudal anterior hypothalamus did not change breathing rate.
Peptide
Dermorphin
Outcome
No significant changeRespiration rate in caudal anterior hypothalamic nucleus
Study
ratn: not reported in source
halothane-anesthetized rats
Outcome group
Respiratory function · Respiratory
Studied dose
40 pmol · intrahypothalamic injectionAs given in this study (rat).
Source sentences
Summary
In the caudal anterior hypothalamic nucleus (A5800-5300), dermorphin, but not vehicle, increased blood pressure 8% and heart rate 26%, without changing respiration rate.
1 context sentence(design, population, supporting numbers)
Summary · context
Central cardiovascular sites of action for dermorphin were determined by injecting 40 pmol of the peptide into discrete sites within the hypothalamus of halothane anesthetized rats.
Report a problemFND-0669724103
04AnimalAnimal study (in vivo)Activity measurement
In anesthetized rats, the dermorphin response peaked at 32 +/- 5 min and lasted more than 90 min.
In plain wordsIn rats, dermorphin's cardiovascular response peaked at 32 +/- 5 min and lasted more than 90 min.
Peptide
Dermorphin
Outcome
Not applicableCardiovascular response timing
Study
ratn: not reported in source
halothane-anesthetized rats
Outcome group
Blood pressure · Cardiovascular
Studied dose
40 pmol · intrahypothalamic injectionAs given in this study (rat).
Measurements
Peak response time
32 min
32 +/- 5 min
Response duration
> 90 min
cardiovascular response
Source sentences
Summary
The peak response was at 32 +/- 5 min, the duration greater than 90 min.
1 context sentence(design, population, supporting numbers)
Summary · context
Central cardiovascular sites of action for dermorphin were determined by injecting 40 pmol of the peptide into discrete sites within the hypothalamus of halothane anesthetized rats.
Report a problemFND-0669724104
05AnimalAnimal study (in vivo)Activity measurement
In rats, dermorphin between medial preoptic and anterior hypothalamic nuclei produced similar heart-rate increases to the caudal anterior site.
In plain wordsIn rats, dermorphin between preoptic and anterior hypothalamic nuclei increased heart rate similarly to the caudal anterior site.
Peptide
Dermorphin
Outcome
IncreaseHeart rate between medial preoptic and anterior hypothalamic nuclei
Study
ratn: not reported in source
halothane-anesthetized rats
Outcome group
Heart function · Cardiovascular
Studied dose
40 pmol · intrahypothalamic injectionAs given in this study (rat).
Source sentences
Summary
Similar increases in heart rate and blood pressure occurred at A6600-6300, the region between medial preoptic and anterior hypothalamic nuclei.
2 context sentences(design, population, supporting numbers)
Summary · context
In the caudal anterior hypothalamic nucleus (A5800-5300), dermorphin, but not vehicle, increased blood pressure 8% and heart rate 26%, without changing respiration rate.
Summary · context
Central cardiovascular sites of action for dermorphin were determined by injecting 40 pmol of the peptide into discrete sites within the hypothalamus of halothane anesthetized rats.
Report a problemFND-0669724105
06AnimalAnimal study (in vivo)Activity measurement
In rats, dermorphin between medial preoptic and anterior hypothalamic nuclei produced similar blood-pressure increases to the caudal anterior site.
In plain wordsIn rats, dermorphin between preoptic and anterior hypothalamic nuclei increased blood pressure similarly to the caudal anterior site.
Peptide
Dermorphin
Outcome
IncreaseBlood pressure between medial preoptic and anterior hypothalamic nuclei
Study
ratn: not reported in source
halothane-anesthetized rats
Outcome group
Blood pressure · Cardiovascular
Studied dose
40 pmol · intrahypothalamic injectionAs given in this study (rat).
Source sentences
Summary
Similar increases in heart rate and blood pressure occurred at A6600-6300, the region between medial preoptic and anterior hypothalamic nuclei.
2 context sentences(design, population, supporting numbers)
Summary · context
In the caudal anterior hypothalamic nucleus (A5800-5300), dermorphin, but not vehicle, increased blood pressure 8% and heart rate 26%, without changing respiration rate.
Summary · context
Central cardiovascular sites of action for dermorphin were determined by injecting 40 pmol of the peptide into discrete sites within the hypothalamus of halothane anesthetized rats.
Report a problemFND-0669724106
07AnimalAnimal study (in vivo)Activity measurement
In rats, dermorphin at septal, medial preoptic, paraventricular hypothalamic and lateral ventricular sites produced small heart-rate increases.
In plain wordsIn rats, dermorphin at the listed septal, preoptic, hypothalamic and ventricular sites slightly increased heart rate.
Peptide
Dermorphin
Outcome
IncreaseHeart rate at septal, medial preoptic, paraventricular and ventricular sites
Study
ratn: not reported in source
halothane-anesthetized rats
Outcome group
Heart function · Cardiovascular
Studied dose
40 pmol · injection into septal area, medial preoptic nucleus, paraventricular hypothalamic nucleus or lateral ventricleAs given in this study (rat).
Source sentences
Summary
Small increases in heart rate, but not blood pressure, resulted from dermorphin injections into the septal area, medial preoptic nucleus, paraventricular hypothalamic nucleus and the lateral ventricle,
1 context sentence(design, population, supporting numbers)
Summary · context
Central cardiovascular sites of action for dermorphin were determined by injecting 40 pmol of the peptide into discrete sites within the hypothalamus of halothane anesthetized rats.
Report a problemFND-0669724107
08AnimalAnimal study (in vivo)Activity measurement
In rats, dermorphin at septal, medial preoptic, paraventricular hypothalamic and lateral ventricular sites did not increase blood pressure.
In plain wordsIn rats, dermorphin at the listed septal, preoptic, hypothalamic and ventricular sites did not increase blood pressure.
Peptide
Dermorphin
Outcome
No significant changeBlood pressure at septal, medial preoptic, paraventricular and ventricular sites
Study
ratn: not reported in source
halothane-anesthetized rats
Outcome group
Blood pressure · Cardiovascular
Studied dose
40 pmol · injection into septal area, medial preoptic nucleus, paraventricular hypothalamic nucleus or lateral ventricleAs given in this study (rat).
Source sentences
Summary
Small increases in heart rate, but not blood pressure, resulted from dermorphin injections into the septal area, medial preoptic nucleus, paraventricular hypothalamic nucleus and the lateral ventricle,
1 context sentence(design, population, supporting numbers)
Summary · context
Central cardiovascular sites of action for dermorphin were determined by injecting 40 pmol of the peptide into discrete sites within the hypothalamus of halothane anesthetized rats.
Report a problemFND-0669724108
09AnimalAnimal study (in vivo)Activity measurement
In rats, dermorphin injections in posterior and dorsomedial hypothalamic nuclei had no effect on blood pressure.
In plain wordsIn rats, dermorphin in posterior and dorsomedial hypothalamic nuclei did not change blood pressure.
Peptide
Dermorphin
Outcome
No significant changeBlood pressure at posterior and dorsomedial hypothalamic sites
Study
ratn: not reported in source
halothane-anesthetized rats
Outcome group
Blood pressure · Cardiovascular
Studied dose
40 pmol · intrahypothalamic injectionAs given in this study (rat).
Source sentences
Summary
while injections in the posterior and dorsomedial hypothalamic nuclei were without effect on blood pressure and heart rate.
1 context sentence(design, population, supporting numbers)
Summary · context
Central cardiovascular sites of action for dermorphin were determined by injecting 40 pmol of the peptide into discrete sites within the hypothalamus of halothane anesthetized rats.
Report a problemFND-0669724109
10AnimalAnimal study (in vivo)Activity measurement
In rats, dermorphin injections in posterior and dorsomedial hypothalamic nuclei had no effect on heart rate.
In plain wordsIn rats, dermorphin in posterior and dorsomedial hypothalamic nuclei did not change heart rate.
Peptide
Dermorphin
Outcome
No significant changeHeart rate at posterior and dorsomedial hypothalamic sites
Study
ratn: not reported in source
halothane-anesthetized rats
Outcome group
Heart function · Cardiovascular
Studied dose
40 pmol · intrahypothalamic injectionAs given in this study (rat).
Source sentences
Summary
while injections in the posterior and dorsomedial hypothalamic nuclei were without effect on blood pressure and heart rate.
1 context sentence(design, population, supporting numbers)
Summary · context
Central cardiovascular sites of action for dermorphin were determined by injecting 40 pmol of the peptide into discrete sites within the hypothalamus of halothane anesthetized rats.
Report a problemFND-0669724110

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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