Feeding, drinking, urine osmolality in DI Brattleboro rats: changes by morphine, naloxone, D-amino acids, prolyl-leucyl-glycinamide (PLG).

Koyuncuoğlu H, Berkman K, Sabuncu H

Pharmacology, biochemistry, and behavior1 Jan 1984Cited by 16 (Europe PMC)

PMID6694997DOI10.1016/0091-3057(84)90095-9PepBankPUB-06694997

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In Brattleboro rats, PLG alone significantly decreased food intake.
In plain wordsIn rats, PLG alone decreased food intake.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
DecreaseFood intake
Study
ratn: not reported in source
Brattleboro rats
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · 7 hoursAs given in this study (rat).
Source sentences
Summary
Mor, Nal, D-Asp and PLG alone caused a significant decrease in food and fluid intake, urine volume and faeces weight and a significant increase in urinary osmolality being the osmolality of the Mor, D-Asp and PLG injected groups higher than 300 mOsmol/kg.
2 context sentences(design, population, supporting numbers)
Summary · context
Brattleboro rats placed in metabolism cages were injected with morphine (Mor), naloxone (Nal), D- and L-aspartic acid (D- and L-Asp), D-phenylalanine (D-Phe), D-leucine (D-Leu) and prolyl-leucyl-glycinamide (PLG), alone and in suitable combinations.
Summary · context
Food and fluid intake, urine outflow, faeces weight, rectal temperature and urinary osmolality were determined at the end of seven hours period of time.
Report a problemFND-0669499701
02AnimalAnimal study (in vivo)Efficacy outcome
In Brattleboro rats, PLG alone significantly decreased fluid intake.
In plain wordsIn rats, PLG alone decreased fluid intake.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
DecreaseFluid intake
Study
ratn: not reported in source
Brattleboro rats
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · 7 hoursAs given in this study (rat).
Source sentences
Summary
Mor, Nal, D-Asp and PLG alone caused a significant decrease in food and fluid intake, urine volume and faeces weight and a significant increase in urinary osmolality being the osmolality of the Mor, D-Asp and PLG injected groups higher than 300 mOsmol/kg.
2 context sentences(design, population, supporting numbers)
Summary · context
Brattleboro rats placed in metabolism cages were injected with morphine (Mor), naloxone (Nal), D- and L-aspartic acid (D- and L-Asp), D-phenylalanine (D-Phe), D-leucine (D-Leu) and prolyl-leucyl-glycinamide (PLG), alone and in suitable combinations.
Summary · context
Food and fluid intake, urine outflow, faeces weight, rectal temperature and urinary osmolality were determined at the end of seven hours period of time.
Report a problemFND-0669499702
03AnimalAnimal study (in vivo)Efficacy outcome
In Brattleboro rats, PLG alone significantly decreased urine volume.
In plain wordsIn rats, PLG alone decreased urine volume.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
DecreaseUrine volume
Study
ratn: not reported in source
Brattleboro rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · 7 hoursAs given in this study (rat).
Source sentences
Summary
Mor, Nal, D-Asp and PLG alone caused a significant decrease in food and fluid intake, urine volume and faeces weight and a significant increase in urinary osmolality being the osmolality of the Mor, D-Asp and PLG injected groups higher than 300 mOsmol/kg.
2 context sentences(design, population, supporting numbers)
Summary · context
Brattleboro rats placed in metabolism cages were injected with morphine (Mor), naloxone (Nal), D- and L-aspartic acid (D- and L-Asp), D-phenylalanine (D-Phe), D-leucine (D-Leu) and prolyl-leucyl-glycinamide (PLG), alone and in suitable combinations.
Summary · context
Food and fluid intake, urine outflow, faeces weight, rectal temperature and urinary osmolality were determined at the end of seven hours period of time.
Report a problemFND-0669499703
04AnimalAnimal study (in vivo)Efficacy outcome
In Brattleboro rats, PLG alone significantly decreased faeces weight.
In plain wordsIn rats, PLG alone decreased faeces weight.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
DecreaseFaeces weight
Study
ratn: not reported in source
Brattleboro rats
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
Dose not stated · 7 hoursAs given in this study (rat).
Source sentences
Summary
Mor, Nal, D-Asp and PLG alone caused a significant decrease in food and fluid intake, urine volume and faeces weight and a significant increase in urinary osmolality being the osmolality of the Mor, D-Asp and PLG injected groups higher than 300 mOsmol/kg.
2 context sentences(design, population, supporting numbers)
Summary · context
Brattleboro rats placed in metabolism cages were injected with morphine (Mor), naloxone (Nal), D- and L-aspartic acid (D- and L-Asp), D-phenylalanine (D-Phe), D-leucine (D-Leu) and prolyl-leucyl-glycinamide (PLG), alone and in suitable combinations.
Summary · context
Food and fluid intake, urine outflow, faeces weight, rectal temperature and urinary osmolality were determined at the end of seven hours period of time.
Report a problemFND-0669499704
05AnimalAnimal study (in vivo)Efficacy outcome
In Brattleboro rats, PLG alone significantly increased urinary osmolality to above 300 mOsmol/kg.
In plain wordsIn rats, PLG alone increased urine concentration.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseUrinary osmolality
Study
ratn: not reported in source
Brattleboro rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · 7 hoursAs given in this study (rat).
Measurements
Urinary osmolality
> 300 mOsmol/kg
PLG group
Source sentences
Summary
Mor, Nal, D-Asp and PLG alone caused a significant decrease in food and fluid intake, urine volume and faeces weight and a significant increase in urinary osmolality being the osmolality of the Mor, D-Asp and PLG injected groups higher than 300 mOsmol/kg.
2 context sentences(design, population, supporting numbers)
Summary · context
Brattleboro rats placed in metabolism cages were injected with morphine (Mor), naloxone (Nal), D- and L-aspartic acid (D- and L-Asp), D-phenylalanine (D-Phe), D-leucine (D-Leu) and prolyl-leucyl-glycinamide (PLG), alone and in suitable combinations.
Summary · context
Food and fluid intake, urine outflow, faeces weight, rectal temperature and urinary osmolality were determined at the end of seven hours period of time.
Report a problemFND-0669499705

Studies that did not test the peptide alone1

In this study, MIF-1 (Pro-Leu-Gly-NH2) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MIF-1 (Pro-Leu-Gly-NH2).

06AnimalNot a test of MIF-1 (Pro-Leu-Gly-NH2) aloneAnimal study (in vivo)Other
In Brattleboro rats, naloxone appeared to intensify PLG-induced changes, while L-aspartic acid antagonized most changes.
In plain wordsIn rats, naloxone appeared to strengthen PLG responses, while L-aspartic acid opposed most responses.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
MixedModification of PLG responses
Study
ratn: not reported in source
Brattleboro rats
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
The combination of Nal with Mor, D-Asp and PLG appeared to intensify the changes induced by Mor, D-Asp and PLG whereas L-Asp antagonized the majority of changes caused by Mor or PLG.
2 context sentences(design, population, supporting numbers)
Summary · context
Brattleboro rats placed in metabolism cages were injected with morphine (Mor), naloxone (Nal), D- and L-aspartic acid (D- and L-Asp), D-phenylalanine (D-Phe), D-leucine (D-Leu) and prolyl-leucyl-glycinamide (PLG), alone and in suitable combinations.
Summary · context
Food and fluid intake, urine outflow, faeces weight, rectal temperature and urinary osmolality were determined at the end of seven hours period of time.
In this study, MIF-1 (Pro-Leu-Gly-NH2) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MIF-1 (Pro-Leu-Gly-NH2).
Report a problemFND-0669499706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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