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Study · Animal study (in vivo) · rat · 1984

2 results

Central cardiovascular effects of vasotocin, oxytocin and vasopressin in conscious rats.

Feuerstein G, Zerbe RL, Faden AI

The Journal of pharmacology and experimental therapeutics1 Feb 1984Cited by 40 (Europe PMC)

PMID6694114 (opens in a new tab)DOI10.1016/s0022-3565(25)21693-7 (opens in a new tab)PepBankPUB-06694114
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, lateral-ventricular oxytocin injections had no significant cardiovascular effects.

    In plain wordsIn conscious rats, oxytocin injected into a brain ventricle had no significant cardiovascular effects.

    Peptide
    Oxytocin
    Outcome
    No significant changeCardiovascular effects
    Study

    ratn: not reported in source

    awake freely moving rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.015-100 nmol · intracerebroventricular injectionAs given in this study (rat).

    Source sentences

    Summary
    In contrast, oxytocin injections into the lateral ventricle (0.015-100 nmol) had no significant cardiovascular effects.
    1 context sentence
    Summary · context
    Arg8-vasotocin (AVT), oxytocin and Arg8-vasopressin (AVP) were injected into the i.c.v. space and/or the hypothalamus of awake, freely moving rats in order to investigate the potential role of these neuropeptides in central cardiovascular control.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, intracerebroventricular oxytocin did not affect plasma vasopressin.

    In plain wordsIn conscious rats, oxytocin injected into a brain ventricle did not affect plasma vasopressin.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma vasopressin
    Study

    ratn: not reported in source

    awake freely moving rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricular injectionAs given in this study (rat).

    Source sentences

    Summary
    Plasma vasopressin was not affected by i.c.v. administration of oxytocin or AVT except at the highest dose of AVT.
    1 context sentence
    Summary · context
    Arg8-vasotocin (AVT), oxytocin and Arg8-vasopressin (AVP) were injected into the i.c.v. space and/or the hypothalamus of awake, freely moving rats in order to investigate the potential role of these neuropeptides in central cardiovascular control.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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