Delta sleep-inducing peptide (DSIP)-like material is absorbed by the gastrointestinal tract of the neonatal rat.

Banks WA, Kastin AJ, Coy DH

Life sciences1 Oct 1983Cited by 20 (Europe PMC)

PMID6688848DOI10.1016/0024-3205(83)90700-2PepBankPUB-06688848

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Pharmacokinetics
In unweaned rat pups, plasma DSIP-like immunoreactivity increased significantly after feeding 100 micrograms of N-Tyr-DSIP, but not after vehicle.
In plain wordsIn rat pups, feeding a DSIP analog raised DSIP-like material in blood at the higher dose, but not after saline.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreasePlasma DSIP-like immunoreactivity after 100 micrograms N-Tyr-DSIP
Study
ratn: not reported in source
Unweaned rat pups
Comparator
Vehicle (normal saline)
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
100 micrograms/animal · oral feedingAs given in this study (rat).
Source sentences
Summary
Significant increases in plasma DSIP-like immunoreactivity occurred after the feeding of 100 micrograms/animal of N-Tyr-DSIP but not after vehicle (normal saline) or 1 microgram/animal.
2 context sentences(design, population, supporting numbers)
Summary · context
Entry of delta sleep-inducing peptide (DSIP) into the circulation from the gastrointestinal (GI) tract was studied in unweaned rat pups.
Summary · context
The pups were fed an analog of DSIP (N-Tyr-DSIP) or 125I-N-Tyr-DSIP and blood samples collected.
Report a problemFND-0668884801
02AnimalAnimal study (in vivo)Pharmacokinetics
In unweaned rat pups, plasma DSIP-like immunoreactivity did not increase significantly after feeding 1 microgram of N-Tyr-DSIP.
In plain wordsIn rat pups, the lower dose of a fed DSIP analog did not raise DSIP-like material in blood.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changePlasma DSIP-like immunoreactivity after 1 microgram N-Tyr-DSIP
Study
ratn: not reported in source
Unweaned rat pups
Comparator
Vehicle (normal saline)
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
1 microgram/animal · oral feedingAs given in this study (rat).
Source sentences
Summary
Significant increases in plasma DSIP-like immunoreactivity occurred after the feeding of 100 micrograms/animal of N-Tyr-DSIP but not after vehicle (normal saline) or 1 microgram/animal.
2 context sentences(design, population, supporting numbers)
Summary · context
Entry of delta sleep-inducing peptide (DSIP) into the circulation from the gastrointestinal (GI) tract was studied in unweaned rat pups.
Summary · context
The pups were fed an analog of DSIP (N-Tyr-DSIP) or 125I-N-Tyr-DSIP and blood samples collected.
Report a problemFND-0668884802
03AnimalAnimal study (in vivo)Mechanism
In rat pups, the plasma immunoreactivity after feeding coeluted with intact DSIP and des-Trp1-DSIP on column chromatography.
In plain wordsIn rat pups, the DSIP-like material in blood after feeding matched intact DSIP and a shortened form.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableIdentity of plasma immunoreactivity after feeding
Study
ratn: not reported in source
Unweaned rat pups
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · oral feedingAs given in this study (rat).
Source sentences
Summary
Column chromatography showed this immunoreactivity to coelute with intact DSIP and des-Trp1-DSIP.
2 context sentences(design, population, supporting numbers)
Summary · context
Entry of delta sleep-inducing peptide (DSIP) into the circulation from the gastrointestinal (GI) tract was studied in unweaned rat pups.
Summary · context
The pups were fed an analog of DSIP (N-Tyr-DSIP) or 125I-N-Tyr-DSIP and blood samples collected.
Report a problemFND-0668884803
04AnimalAnimal study (in vivo)Pharmacokinetics
In rat pups, a small but statistically significant increase of plasma immunoreactivity occurred when the nursing mothers were injected with N-Tyr-DSIP, but not saline.
In plain wordsIn rat pups, a small rise of DSIP-like material in blood occurred when nursing mothers were injected with a DSIP analog.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreasePlasma immunoreactivity in pups of mothers injected with N-Tyr-DSIP
Study
ratn: not reported in source
Unweaned rat pups
Comparator
Saline-injected mothers
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · injection into nursing mothersAs given in this study (rat).
Source sentences
Summary
A small but statistically significant increase of immunoreactivity occurred in the plasma of pups whose nursing mothers were injected with N-Tyr-DSIP but not in those whose mothers were injected with saline.
2 context sentences(design, population, supporting numbers)
Summary · context
Entry of delta sleep-inducing peptide (DSIP) into the circulation from the gastrointestinal (GI) tract was studied in unweaned rat pups.
Summary · context
The pups were fed an analog of DSIP (N-Tyr-DSIP) or 125I-N-Tyr-DSIP and blood samples collected.
Report a problemFND-0668884804
05AnimalAnimal study (in vivo)Pharmacokinetics
In 1-2 and 10 day old rat pups, radioactivity appeared in both brain and blood after feeding 125I-N-Tyr-DSIP.
In plain wordsIn rat pups, radioactive labeled DSIP analog reached both blood and brain after feeding.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseRadioactivity in brain and blood after feeding 125I-N-Tyr-DSIP
Study
ratn: not reported in source
Unweaned rat pups
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · oral feedingAs given in this study (rat).
Source sentences
Summary
Radioactivity appeared in both the brain and blood of 1-2 and 10 day old rat pups fed 125I-N-Tyr-DSIP.
2 context sentences(design, population, supporting numbers)
Summary · context
Entry of delta sleep-inducing peptide (DSIP) into the circulation from the gastrointestinal (GI) tract was studied in unweaned rat pups.
Summary · context
The pups were fed an analog of DSIP (N-Tyr-DSIP) or 125I-N-Tyr-DSIP and blood samples collected.
Report a problemFND-0668884805
06AnimalAnimal study (in vivo)Mechanism
In rat pups, only a small amount of plasma radioactivity but almost all brain radioactivity coeluted with intact 125I-N-Tyr-DSIP, suggesting the peptide crossed the blood-brain barrier.
In plain wordsIn rat pups, almost all radioactivity in the brain was intact labeled peptide, suggesting it crossed into the brain.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableIntact labeled peptide in plasma and brain
Study
ratn: not reported in source
Unweaned rat pups
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · oral feedingAs given in this study (rat).
Source sentences
Summary
Although only a small amount of the radioactivity in plasma co-eluted with intact 125I-N-Tyr-DSIP on column chromatography, almost all of the radioactivity in brain did, suggesting that the radioactivity in the brain represented crossing of the blood-brain-barrier by the peptide and not just contamination by blood.
2 context sentences(design, population, supporting numbers)
Summary · context
Entry of delta sleep-inducing peptide (DSIP) into the circulation from the gastrointestinal (GI) tract was studied in unweaned rat pups.
Summary · context
The pups were fed an analog of DSIP (N-Tyr-DSIP) or 125I-N-Tyr-DSIP and blood samples collected.
Report a problemFND-0668884806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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