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Study · Animal study (in vivo) · mouse · 1983

3 results

Studies of the thymus in mice bearing the Lewis lung carcinoma. II. Modulation of thymic natural killer activity by thymulin (FTS-Zn) and the antimetastatic effect of zinc.

Kaiserlian D, Savino W, Dardenne M

Clinical immunology and immunopathology1 Aug 1983Cited by 4 (Europe PMC)

PMID6688208 (opens in a new tab)DOI10.1016/0090-1229(83)90154-x (opens in a new tab)PepBankPUB-06688208
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In amputated tumor-bearing mice, thymulin decreased the elevated thymic NK activity.

    In plain wordsIn mice with tumors and amputation, thymulin reduced elevated natural killer activity in the thymus.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseThymic NK activity in amputated mice
    Study

    mousen: not reported in source

    Lewis lung carcinoma-bearing mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymulin decreased the increased NK activity found in amputated (tumor) tumor-bearing mice
    1 context sentence
    Summary · context
    Modulation of thymic natural killer (NK) cell activity by the serum thymic factor (thymulin or FTS-Zn) was demonstrated in mice carrying the Lewis lung carcinoma (3LL).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In nonamputated tumor-bearing mice, thymulin induced significant thymic NK activity where activity was normally absent.

    In plain wordsIn mice with tumors and no amputation, thymulin induced natural killer activity in the thymus.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseThymic NK activity in nonamputated mice
    Study

    mousen: not reported in source

    Lewis lung carcinoma-bearing mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymulin decreased the increased NK activity found in amputated (tumor) tumor-bearing mice and induced a significant NK activity in nonamputated mice, normally devoid of such activity.
    1 context sentence
    Summary · context
    Modulation of thymic natural killer (NK) cell activity by the serum thymic factor (thymulin or FTS-Zn) was demonstrated in mice carrying the Lewis lung carcinoma (3LL).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In amputated tumor-bearing mice, adding thymulin suppressed the reduction in lung metastases observed with zinc.

    In plain wordsIn mice with tumors and amputation, adding thymulin suppressed the reduction in lung metastases seen with zinc alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseZinc-associated reduction in lung metastases
    Study

    mousen: not reported in source

    Lewis lung carcinoma-bearing mice
    Comparator
    Zinc alone
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This effect was suppressed by concomitant administration of thymulin to amputated mice.
    2 context sentences
    Summary · context
    A clear-cut decrease in the number of lung metastases was observed in zinc-treated mice.
    Summary · context
    Modulation of thymic natural killer (NK) cell activity by the serum thymic factor (thymulin or FTS-Zn) was demonstrated in mice carrying the Lewis lung carcinoma (3LL).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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