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Study · Animal study (in vivo) · rat · 1983

2 results

Human growth hormone and somatomedin C suppress the spontaneous release of growth hormone in unanesthetized rats.

Abe H, Molitch ME, Van Wyk JJ, Underwood LE

Endocrinology1 Oct 1983Cited by 124 (Europe PMC)

PMID6684547 (opens in a new tab)DOI10.1210/endo-113-4-1319 (opens in a new tab)PepBankPUB-06684547
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, intravenous hGH significantly inhibited GH secretory surge amplitude versus control.

    In plain wordsIn rats, intravenous human growth hormone reduced growth hormone surges compared with control.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseGH secretory surge amplitude after intravenous hGH
    Study

    ratn = 6

    Unanesthetized freely moving rats
    Comparator
    Crystalline BSA control
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.3 U loading dose, then 0.3 U/ml.h · intravenous · 6 hAs given in this study (rat).

    Measurements

    Secretory profile area
    752 not stated
    hGH; +/- 172
    Secretory profile area
    1921 not stated
    control; +/- 183
    P value
    < 0.01 unitless
    hGH versus control

    Source sentences

    Summary
    The iv infusion of hGH significantly inhibited the amplitude of rGH surges compared to controls (planimetric areas under the secretory profile 752 +/- 172 vs. 1921 +/- 183, P less than 0.01, n = 6).
    3 context sentences
    Summary · context
    For iv studies, hGH (0.3 U/ml.h) was infused for 6 h after an iv loading dose (0.3 U) at the beginning of the experiments.
    Summary · context
    To investigate the feedback control of GH secretion, we examined the effects of human GH (hGH) and somatomedin C (SmC) on spontaneous GH secretory surges in unanesthetized, freely moving rats.
    Summary · context
    The equivalent dose of crystalline BSA diluted in the same vehicle solutions was administered to the same rat as a control on a separate day.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, intraventricular hGH significantly inhibited GH secretion versus control.

    In plain wordsIn rats, human growth hormone injected into a brain ventricle reduced growth hormone secretion compared with control.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseGH secretion after intraventricular hGH
    Study

    ratn = 6

    Unanesthetized freely moving rats
    Comparator
    Crystalline BSA control
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.1 U/10 microliter · intraventricularAs given in this study (rat).

    Measurements

    Secretory profile area
    701 not stated
    hGH; +/- 127
    Secretory profile area
    2208 not stated
    control; + 225
    P value
    < 0.01 unitless
    hGH versus control

    Source sentences

    Summary
    rGH secretion was similarly inhibited by intraventricular hGH (701 +/- 127 vs. 2208 + 225, P less than 0.01, n = 6) and
    3 context sentences
    Summary · context
    For intraventricular injections, hGH (0.1 U/10 microliter) or SmC (500 ng/10 microliter) were injected into the lateral ventricle 2 h before the experiments.
    Summary · context
    To investigate the feedback control of GH secretion, we examined the effects of human GH (hGH) and somatomedin C (SmC) on spontaneous GH secretory surges in unanesthetized, freely moving rats.
    Summary · context
    The equivalent dose of crystalline BSA diluted in the same vehicle solutions was administered to the same rat as a control on a separate day.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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